Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 24, 2025
Polyphenols,
naturally
occurring
phytonutrients
found
in
plant-based
foods,
have
attracted
significant
attention
for
their
potential
therapeutic
effects
neurological
diseases
and
neuroinflammation.
These
compounds
possess
diverse
neuroprotective
capabilities,
including
antioxidant,
anti-inflammatory,
anti-amyloid
properties,
which
contribute
to
mitigating
the
progression
of
neurodegenerative
conditions
such
as
Alzheimer's
Disease
(AD),
Parkinson's
(PD),
Dementia,
Multiple
Sclerosis
(MS),
Stroke,
Huntington's
(HD).
Polyphenols
been
extensively
studied
ability
regulate
inflammatory
responses
by
modulating
activity
pro-inflammatory
genes
influencing
signal
transduction
pathways,
thereby
reducing
neuroinflammation
neuronal
death.
Additionally,
polyphenols
shown
promise
various
cellular
signaling
pathways
associated
with
viability,
synaptic
plasticity,
cognitive
function.
Epidemiological
clinical
studies
highlight
polyphenol-rich
diets
decrease
risk
alleviate
symptoms
disorders
Furthermore,
demonstrated
through
regulation
key
Akt,
Nrf2,
STAT,
MAPK,
play
critical
roles
neuroprotection
body's
immune
response.
This
review
emphasizes
growing
body
evidence
supporting
combating
neurodegeneration
neuroinflammation,
well
enhancing
brain
health.
Despite
substantial
promising
hypotheses,
further
research
investigations
are
necessary
fully
understand
role
establish
them
advanced
targets
age-related
neuroinflammatory
conditions.
Language: Английский
Inflammatory plasma profile in genetic symptomatic and presymptomatic Frontotemporal Dementia − A GENFI study
Brain Behavior and Immunity,
Journal Year:
2024,
Volume and Issue:
122, P. 231 - 240
Published: Aug. 15, 2024
Language: Английский
Unveiling the complexity of Alzheimer's disease: Introduction and its pathophysiology
Elsevier eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 15
Published: Oct. 25, 2024
Language: Английский
Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12701 - 12701
Published: Nov. 26, 2024
Foeniculum
vulgare
Mill,
commonly
known
as
fennel,
is
an
aromatic
herb
traditionally
used
for
culinary
and
medicinal
purposes,
with
potential
therapeutic
effects
on
neurological
disorders.
However,
limited
research
has
focused
its
neurotrophic
impact,
particularly
neuronal
maturation
synaptic
development.
This
study
investigates
the
of
F.
ethanol
extracts
(FVSE)
rat
primary
hippocampal
neurons.
Results
show
that
FVSE
prominent
component,
anethole,
significantly
promote
neurite
outgrowth
in
a
dose-dependent
manner.
Optimal
axonal
dendritic
growth
occurred
at
concentrations
40
µg/mL
20
µM
respectively,
without
causing
cytotoxicity,
underscoring
safety
health.
Additionally,
enhances
formation
synapses,
essential
communication.
Network
pharmacology
analysis
revealed
components
influence
critical
pathways,
including
PI3K-AKT
Alzheimer’s
disease
pathways.
Specifically,
modulates
key
proteins,
tropomyosin
receptor
kinase
(Trk),
glycogen
synthase
3
(GSK3βser9),
phosphatidylinositol
3-kinase
(PI3K),
extracellular
signal-regulated
protein
(Erk1/2).
Anethole
was
found
to
play
role
regulating
these
which
confirmed
by
immunocytochemistry
experiments
demonstrating
effect
promoting
In
conclusion,
this
highlights
properties
FVSE,
anethole
emerging
bioactive
compound.
These
findings
provide
valuable
insights
into
fennel
treating
disorders,
offering
basis
future
interventions
survival.
Language: Английский