Dynamic Changes in Human Brain Connectivity Following Ultrasound Neuromodulation DOI Creative Commons
Cyril Atkinson-Clément,

Mohammad Alkhawashki,

Marilyn Gatica

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

Abstract Non-invasive neuromodulation represents a major opportunity for brain and mental health interventions. Based on its ability to target deep-brain structures, transcranial focused ultrasound is the most promising approach, destined change clinical practice. However, some challenges prevent community from fully understanding outcomes therefore moving next research step. Here we addressed one of them unravelled temporal dynamics effects in humans. Our findings reveal that are predominantly time-constrained spatially distributed regions functionally connected with directly stimulated area. Furthermore, these biological indicative behavioural changes persist at least an hour following stimulation. study provides detailed how stimulation alters function over time. This first step towards future prediction dynamic terms activity behaviour, including both immediate (recorded during stimulation) long-term consequences (hours or days after neuromodulation.

Language: Английский

Neuromodulation techniques – From non-invasive brain stimulation to deep brain stimulation DOI Creative Commons
Benjamin Davidson, Amitabh Bhattacharya, Can Sarica

et al.

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(3), P. e00330 - e00330

Published: Feb. 9, 2024

Over the past 30 years, field of neuromodulation has witnessed remarkable advancements. These developments encompass a spectrum techniques, both non-invasive and invasive, that possess ability to probe influence central nervous system. In many cases therapies have been adopted into standard care treatments. Transcranial magnetic stimulation (TMS), transcranial direct current (tDCS), ultrasound (TUS) are most common methods in use today. Deep brain (DBS), spinal cord (SCS), vagus nerve (VNS), leading surgical for neuromodulation. Ongoing active clinical trials using uncovering novel applications paradigms these interventions.

Language: Английский

Citations

32
Effects of different sonication parameters of theta burst transcranial ultrasound stimulation on human motor cortex DOI Creative Commons
Ke Zeng, Zhiwei Li, Xue Xia

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(2), P. 258 - 268

Published: March 1, 2024

BackgroundTheta burst TUS (tbTUS) can induce increased cortical excitability in human, but how different sonication parameters influence the effects are still unknown.ObjectiveTo examine a range of parameters, including acoustic intensity, pulse repetition frequency, duty cycle and duration, tbTUS on human motor excitability.Methods14 right-handed healthy subjects underwent 8 sessions with randomized, cross-over design separate days. The original protocol was studied one session parameter changed each seven sessions. To changes induced by tbTUS, we measured motor-evoked potential (MEP) amplitude, resting threshold, short-interval intracortical inhibition facilitation, as well facilitation before up to 90 min after tbTUS.ResultsAll conditions MEP amplitudes except condition low intensity 10 W/cm2. Pulse frequency 5 Hz produced higher compared frequencies 2 Hz. In addition, cycles (5%, 10%, 15%) longer durations (40, 80, 120 s) were associated duration amplitudes. Resting threshold remained stable all conditions. For paired-pulse TMS measures, reduced enhanced had no effect facilitation.ConclusionsUltrasound bursts repeated at theta (∼5 Hz) is optimal produce 2–10 Furthermore, there dose-response regarding for plasticity induction. aftereffects shift inhibition/excitation balance toward less more excitation cortex. These findings be used determine neuroscience research treatment neurological psychiatric disorders.

Language: Английский

Citations

26
A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound DOI Creative Commons

K.W. Lee,

Tae‐Young Park, Wonhye Lee

et al.

Biomedical Engineering Letters, Journal Year: 2024, Volume and Issue: 14(3), P. 407 - 438

Published: March 2, 2024

Transcranial ultrasonic neuromodulation is a rapidly burgeoning field where low-intensity transcranial focused ultrasound (tFUS), with exquisite spatial resolution and deep tissue penetration, used to non-invasively activate or suppress neural activity in specific brain regions. Over the past decade, there has been rapid increase of tFUS studies healthy humans subjects central nervous system (CNS) disease conditions, including recent surge clinical investigations patients. This narrative review summarized findings human using either unfocused (TUS) reported from 2013 2023. The were categorized into two separate sections: research studies. A total 42 reviewed as grouped by targeted regions, various cortical, subcortical, areas thalamus. For research, 22 articles for each studied CNS condition, chronic pain, disorder consciousness, Alzheimer's disease, Parkinson's depression, schizophrenia, anxiety disorders, substance use disorder, drug-resistant epilepsy, stroke. Detailed information on subjects/cohorts, target sonication parameters, outcome readouts, stimulatory efficacies tabulated study. In later sections, considerations planning also concisely discussed. With an excellent safety profile date, growth underscores increasing interest recognition its significant potential non-invasive stimulation (NIBS), offering theranostic neurological psychiatric conditions neuroscientific tools functional mapping.

Language: Английский

Citations

19
A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium DOI Creative Commons

Keith R. Murphy,

Tulika Nandi, Benjamin R. Kop

et al.

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Transcranial focused ultrasound to V5 enhances human visual motion brain-computer interface by modulating feature-based attention DOI Creative Commons
Joshua Kosnoff, Kai Yu, Chang Liu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 11, 2024

Abstract A brain-computer interface (BCI) enables users to control devices with their minds. Despite advancements, non-invasive BCIs still exhibit high error rates, prompting investigation into the potential reduction through concurrent targeted neuromodulation. Transcranial focused ultrasound (tFUS) is an emerging neuromodulation technology spatiotemporal precision. This study examines whether tFUS can improve BCI outcomes, and explores underlying mechanism of action using high-density electroencephalography (EEG) source imaging (ESI). As a result, V5-targeted significantly reduced in speller task. Source analyses revealed increase theta alpha activities condition at both V5 downstream dorsal visual processing pathway. Correlation analysis indicated that connection within pathway was preserved during stimulation, while ventral weakened. These findings suggest enhances feature-based attention motion.

Language: Английский

Citations

12
Sustained reduction of essential tremor with low-power non-thermal transcranial focused ultrasound stimulations in humans DOI Creative Commons
Thomas Bancel, Benoît Béranger,

Maxime Daniel

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(3), P. 636 - 647

Published: May 1, 2024

Language: Английский

Citations

11
DORSAL RAPHE NUCLEUS CONTROLS MOTIVATIONAL STATE TRANSITIONS IN MONKEYS DOI Creative Commons

Luke Priestley,

Mark Chiew, Mo Shahdloo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 14, 2024

ABSTRACT The dorsal raphe nucleus (DRN) is an important source of serotonin in the brain but fundamental aspects its function remain elusive. Here, we present a combination minimally invasive recording and disruption studies to show that DRN brings about changes motivation states. We use recently developed methods for identifying temporal patterns behaviour monkeys change their depending on availability rewards environment. Distinctive activity occur when transition between high state occupied are abundant, low engendered by reward scarcity. Disrupting diminishes sensitivity environment perturbs transitions motivational

Language: Английский

Citations

8
Plasticity‐Induced Effects of Theta Burst Transcranial Ultrasound Stimulation in Parkinson's Disease DOI Creative Commons
Talyta Grippe,

Yazan Shamli‐Oghli,

Ghazaleh Darmani

et al.

Movement Disorders, Journal Year: 2024, Volume and Issue: 39(8), P. 1364 - 1374

Published: May 24, 2024

Abstract Background Low‐intensity transcranial ultrasound stimulation (TUS) is a noninvasive brain (NIBS) technique with high spatial specificity. Previous studies showed that TUS delivered in theta burst pattern (tbTUS) increased motor cortex (MI) excitability up to 30 minutes due long‐term potentiation (LTP)–like plasticity. Studies using other forms of NIBS suggested cortical plasticity may be impaired patients Parkinson's disease (PD). Objective The aim was investigate the neurophysiological effects tbTUS PD off and on dopaminergic medications compared healthy controls. Methods We studied 20 moderately affected medication states (7 13 without dyskinesia) 17 age‐matched controls case‐controlled study. applied for 80 seconds MI. Motor‐evoked potentials (MEP), short‐interval intracortical inhibition (SICI), facilitation (SICF) were recorded at baseline, 5 (T5), T30, T60 after tbTUS. Motor Unified Disease Rating Scale (mUPDRS) measured baseline T60. Results significantly MEP amplitude T30 but not medications. SICI reduced did change or SICF. bradykinesia subscore mUPDRS state. presence dyskinesia affect tbTUS‐induced Conclusions LTP restored by © 2024 Author(s). Movement Disorders published Wiley Periodicals LLC behalf International Parkinson Disorder Society.

Language: Английский

Citations

7
Ultrasound system for precise neuromodulation of human deep brain circuits DOI Creative Commons
Eleanor Martin,

Morgan Roberts,

Ioana Grigoraş

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Abstract Transcranial ultrasound stimulation (TUS) has emerged as a promising technique for non-invasive neuromodulation, but current systems lack the precision to target deep brain structures effectively. Here, we introduce an advanced TUS system that achieves unprecedented in neuromodulation. The features 256-element, helmet-shaped transducer array operating at 555 kHz, coupled with stereotactic positioning system, individualised treatment planning, and real-time monitoring using functional MRI. In series of experiments, demonstrate system’s ability selectively modulate activity lateral geniculate nucleus (LGN) its functionally connected regions visual cortex. Participants exhibited significantly increased cortex during concurrent stimulation, high reproducibility across individuals. Moreover, theta-burst protocol induced robust neuromodulatory effects, decreased observed least 40 minutes post-stimulation. These effects were specific targeted LGN, confirmed by control experiments. Our findings highlight potential this non-invasively circuits specificity, offering new avenues studying function developing therapies neurological psychiatric disorders. spatial resolution prolonged transformative technology both research clinical applications, paving way era

Language: Английский

Citations

6
Effects of the motor cortical theta‐burst transcranial‐focused ultrasound stimulation on the contralateral motor cortex DOI Creative Commons
Xue Xia, Zhen Wang, Ke Zeng

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 602(12), P. 2931 - 2943

Published: May 2, 2024

Abstract Theta‐burst transcranial ultrasound stimulation (tbTUS) increases primary motor cortex (M1) excitability for at least 30 min. However, the remote effects of focal M1 tbTUS on other cortical areas are unknown. Here, we examined left right excitability. An 80 s train active or sham was delivered to in 20 healthy subjects. Before and after tbTUS, measured: (1) corticospinal using motor‐evoked potential (MEP) amplitudes from single‐pulse magnetic (TMS) M1; (2) interhemispheric inhibition (IHI) a dual‐site paired‐pulse TMS paradigm; (3) intracortical circuits with short‐interval facilitation (ICF) TMS. Left decreased as shown by MEP amplitudes, increased ICF IHI hemisphere interstimulus interval (ISI) 10 ms but not long‐interval 40 ms. The study showed that can change inhibition. should be considered when it is used neuroscience research neuromodulation treatment brain disorders. image Key points Transcranial (TUS) novel non‐invasive technique advantages being able achieve high spatial resolution target deep structures. A repetitive TUS protocol, an theta burst patterned (tbTUS), has been increase excitability, well alpha beta movement‐related spectral power distinct regions. In this study, contralateral measured MEPs elicited stimulation. We left‐to‐right inhibition, M1. These results lead better understand help development neurological psychiatric disorders research.

Language: Английский

Citations

4