Neuromodulation Technology at the Neural Interface, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Language: Английский
Science, Journal Year: 2024, Volume and Issue: 385(6714)
Published: Sept. 12, 2024
Focused ultrasound is a platform technology capable of eliciting wide range biological responses with high spatial precision deep within the body. Although focused already in clinical use for focal thermal ablation tissue, there has been recent growth development and translation ultrasound-mediated nonthermal therapies. These approaches exploit physical forces to produce dependent on exposure conditions. This review discusses advances four application areas that have seen particular immense potential: brain drug delivery, neuromodulation, tissue destruction, endogenous immune system activation. Owing maturation transcranial technology, major target organ; however, indications outside are also discussed.
Language: Английский
Citations
15
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: June 19, 2024
Unmatched by other non-invasive brain stimulation techniques, transcranial ultrasound (TUS) offers highly focal not only on the cortical surface but also in deep structures. These unique attributes are invaluable both basic and clinical research might open new avenues for treating neurological psychiatric diseases. Here, we provide a concise overview of expanding volume investigations recent years upcoming initiatives concerning focused neuromodulation. Currently, TUS addresses variety neuropsychiatric conditions, such as pain, dementia, movement disorders, epilepsy, disorders consciousness, developmental disorders. As demonstrated sham-controlled randomized studies, neuromodulation improved cognitive functions mood, alleviated symptoms schizophrenia autism. Further, preliminary uncontrolled evidence suggests relieved anxiety, enhanced motor reduced epileptic seizure frequency, responsiveness patients with minimally conscious state, well pain reduction after neuromodulatory TUS. While constrained relatively modest number investigations, primarily consisting feasibility trials small sample sizes, holds encouraging prospects Larger trials, alongside further into mechanisms action optimal sonication parameters, inevitably needed to unfold full potential
Language: Английский
Citations
7
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 8, 2024
Abstract Transcranial ultrasound stimulation (TUS) has emerged as a promising technique for non-invasive neuromodulation, but current systems lack the precision to target deep brain structures effectively. Here, we introduce an advanced TUS system that achieves unprecedented in neuromodulation. The features 256-element, helmet-shaped transducer array operating at 555 kHz, coupled with stereotactic positioning system, individualised treatment planning, and real-time monitoring using functional MRI. In series of experiments, demonstrate system’s ability selectively modulate activity lateral geniculate nucleus (LGN) its functionally connected regions visual cortex. Participants exhibited significantly increased cortex during concurrent stimulation, high reproducibility across individuals. Moreover, theta-burst protocol induced robust neuromodulatory effects, decreased observed least 40 minutes post-stimulation. These effects were specific targeted LGN, confirmed by control experiments. Our findings highlight potential this non-invasively circuits specificity, offering new avenues studying function developing therapies neurological psychiatric disorders. spatial resolution prolonged transformative technology both research clinical applications, paving way era
Language: Английский
Citations
6
PLoS Biology, Journal Year: 2024, Volume and Issue: 22(10), P. e3002884 - e3002884
Published: Oct. 29, 2024
Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene restore them. Developing technologies that can precisely interface with any region may combine diagnostics therapeutic intervention, expediting personalised medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution this challenge, offering focal precision scalability. By exploiting the biomechanics pressure waves on tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in cortex deeper areas alike. In Essay, we explore emergent evidence functionally test modify dysfunctional regions, effectively serving as search rescue tool for brain. We define challenges opportunities faced by it moves towards greater target integration advanced monitoring interventional technology. Finally, propose roadmap evolution progresses from research clinically validated disorders.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 2, 2025
This paper describes the design and initial proof-of-concept of a single pre-clinical transcranial focused ultrasound (FUS) system capable performing histotripsy (mechanical ablation), hyperthermia, blood-brain barrier opening (BBBO), sonodynamic therapy, or neuromodulation in murine brain. We have termed it All-in-One FUS for brain studies, which is first its kind. The 1.5 MHz transducer was fabricated driven using custom electronic driver to produce 3-cycle pulses with focal peak-negative pressure (P-) up 87 MPa at low duty cycle (< 0.1%) as well 50% pulsed-ultrasound spatial-peak temporal-average intensity (Ispta) 251 W/cm2 other modalities. can be guided by MRI stereotactically maximize flexibility. To validate system, histotripsy, BBBO, hyperthermia were performed naïve brains two mice each modality. Histotripsy BBBO MRI-based stereotactic co-registration. therapeutic effect confirmed T2-weighted MR-images T1-weighted Gadolinium contrast-enhanced BBBO. For an MRI-compatible insert designed fit inside 80 mm imaging coil 7-Tesla small-animal MRI-system, used confirm targeting, MR-thermometry monitor thermal dose delivered.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Transcranial ultrasonic stimulation (TUS) redefines what is possible with non-invasive neuromodulation by oaering unparalleled spatial precision and flexible targeting capabilities. However, peripheral confounds pose a significant challenge to reliably implementing this technology. While auditory during TUS have been studied extensively, the somatosensory confound has overlooked thus far. It will become increasingly vital quantify manage as field shifts towards higher doses, more compact devices, frequent through temple where co-stimulation pronounced. Here, we provide systematic characterisation of TUS. We also identify conditions under which can be mitigated most eaectively mapping confound-parameter space. Specifically, investigate dose-response eaects, pulse shaping characteristics, transducer-specific parameters. demonstrate that avoiding near-field intensity peaks in scalp, spreading energy across greater area ramping envelope, delivering equivalent doses via longer, lower-intensity pulses rather than shorter, higher-intensity pulses. Additionally, repetition frequencies fundamental reduce eaects. Through our parameter space, find preliminary evidence particle displacement (strain) may primary biophysical driving force behind co-stimulation. This study provides actionable strategies minimise confounds, support thorough experimental control required unlock full potential for scientific research clinical interventions. Tactile, thermal, even painful occur TUS.Confounds & parameters.Valid replicable requires confounds.Particle confounds.
Language: Английский
Citations
0
Expert Review of Medical Devices, Journal Year: 2025, Volume and Issue: unknown
Published: April 4, 2025
Magnetic resonance-guided focused ultrasound (MRgFUS) has emerged as a leading noninvasive therapy for tremor, offering precise, lesion-based alternative to deep brain stimulation (DBS) and traditional lesioning techniques. By using phased arrays focus energy at intracranial targets, MRgFUS allows real-time visualization monitoring, improving safety efficacy. Initially developed essential tremor (ET), MRgFUS-VIM-thalamotomy gained widespread acceptance is now first-line option tremor-dominant Parkinson's disease (TDPD) other syndromes. This review discusses the fundamental physics of ultrasound, key anatomical clinical application thalamotomy, pallidotomy, subthalamotomy. Skull density ratio (SDR) efficiency are highlighted crucial factors affecting treatment outcomes. The evolution bilateral treatment, along with exploration novel targets such pallidothalamic tract, examined. Additionally, we discuss advancements in FUS neuromodulation, which could complement by providing temporary or reversible symptom relief. poised further revolutionize frameless technology, staged procedures, integration neuromodulation. Future developments may allow adaptive therapies that enhance both efficacy patient experience.
Language: Английский
Citations
0
CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(4)
Published: April 1, 2025
ABSTRACT Aims Neurological diseases like Alzheimer's disease (AD) with cognitive deficits show impaired theta, gamma, and ripple bands. Restoring these oscillations may be crucial for rescuing functions. Low‐intensity transcranial ultrasound stimulation (TUS), a noninvasive neuromodulation method, offers high spatial resolution deep penetration. However, it remains unclear how 40 Hz 200 TUS improve memory in AD by regulating hippocampal oscillations. Methods We applied to the CA1 region of mice, performing assessments electrophysiology recordings simultaneously. Results Our results showed that both significantly improved performance mice targeting dorsal hippocampus increasing power corresponding frequency Specifically, enhanced gamma bands, while strongly affected both. This enhancement increased during persisted 5 days poststimulation. Improved coupling between theta indicated better coordination other brain regions. Additionally, raised sharp wave (SPW‐Rs) incidence, SPW‐R incidence duration, contributing improvement. Behavioral at frequencies. Conclusion Ultrasound‐induced synchronized neural activities entrained disease.
Language: Английский
Citations
0
International Journal of Hyperthermia, Journal Year: 2025, Volume and Issue: 42(1)
Published: April 27, 2025
MR-guided focused ultrasound (MRgFUS) has been developed to treat essential tremor effectively and noninvasively. Currently, clinical examination is used identify therapeutic efficacy during treatment, but MRgFUS surgery could benefit from real-time, rater-independent quantitative monitoring of tremor, such as accelerometry data. Fourteen patients with medically refractory underwent thalamotomy. Patients were instructed hold postures treatment. Tremor was monitored each ultrasonic thermal sonication MR-compatible accelerometers. Real-time feedback based on amplitude in the 2-20 Hz band calculated evaluate ablation. On average 6 ± 2 ablative sonications only required induce improvement rating scale for (CRST) 89 11% at D + 7, 79 12% M 1, 74 19% 3 72 23% 12. The overall predictive measured treatment 70 30%. reduction correlated CRST scores multiple timepoints (ρ = 0.79 ρ 0.75 0.86 3, 0.63 12) accelerometric data gathered predicted (0.88 area under ROC curve). This exploratory study a proof concept suggesting that measurements can provide real-time complement visual evaluation. In future, use outcome prediction introduced this paper may shorten procedure time limit adverse events by reducing number administered sonications.
Language: Английский
Citations
0
Brain stimulation, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Neuromodulation of deep brain regions has shown promise for treatment-resistant depression (TRD). However, it currently requires neurosurgical electrode implantation, posing significant risks and limiting widespread use while TRD affects around 100 million people worldwide. Low-intensity transcranial ultrasound stimulation (TUS) could allow precise non-invasive neuromodulation, provided that the challenge defocusing effects skull is tackled. Here, we present development a portable neuronavigated TUS prototype based on patient-specific metamaterials (metalens) correct skull-induced aberrations. We then first application metalens-based Transcranial Ultrasound Stimulation (mTUS) in TRD. The primary objective was to assess safety efficacy mTUS targeting individual level specific white matter tracts subcallosal cingulate involved precision this device addressed through series numerical simulations experimental measurements ex vivo human skulls. Five participants with were included open-label study (ClinicalTrials.gov identifier: NCT06085950) underwent an intensive 5-day course total 25 sessions 5 minutes each. No serious adverse events occurred during study. By day treatment, severity reduced by average 60.9% (range: [30% - 83.9%]), four out five patients qualified as responders, two them remission. This provides first-in-human evidence potential precise, safe effective neuromodulation technique neuropsychiatric disorders involving regions, offering safer more accessible alternative invasive approaches.
Language: Английский
Citations
0