Cancer situation in China: what does the China cancer map indicate from the first national death survey to the latest cancer registration?

Cancer Communications, Journal Year: 2022, Volume and Issue: 43(1), P. 75 - 86

Published: Nov. 17, 2022

Abstract Background Over the past four decades, Chinese government has conducted three surveys on distribution of causes death and built cancer registration. In order to shine a new light better prevention strategies in China, we evaluated profile mortality over forty years analyzed policies that have been implemented. Methods We described spatial temporal changes both ranking major types China based data collected from national during 1973‐1975, 1990‐1992, 2004‐2005, latest registration published by National Central Cancer Registry China. The were compared after conversion age‐standardized rates world standard population (Segi's population). geographical characteristics explored marking hot spots different cancers map Results From 1973 2016, witnessed an evident decrease rate stomach, esophageal, cervical cancer, while gradual increase was recorded lung, colorectal, female breast cancer. A slight observed liver since 2004. Lung however, become top two leading for last twenty years. surveys, similar profiles among urban rural areas. Lower esophageal stomach demonstrated than Rural areas had five with small 1973‐1975. Additionally, 2016 also approximate 2004‐2005. Moreover, showed specific distributions. Although decreased at most hotspots these cancers, they still higher average levels same time periods. Conclusions Building up strong primary public health system especially may be one critical step reduce burden

Language: Английский

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Colorectal cancer and gut microbiota studies in China

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: July 23, 2023

Colorectal cancer (CRC) is the third most common malignant tumor worldwide. The incidence and mortality rates of CRC have been increasing in China, possibly due to economic development, lifestyle, dietary changes. Evidence suggests that gut microbiota plays an essential role tumorigenesis CRC. Gut dysbiosis, specific pathogenic microbes, metabolites, virulence factors, microbial carcinogenic mechanisms contribute initiation progression biomarkers potential translational applications screening early diagnosis. microbiota-related interventions could improve anti-tumor therapy's efficacy severe intestinal toxic effects. Chinese researchers made many achievements relationship between CRC, although some challenges remain. This review summarizes current evidence from China on mainly including characteristics, especially Fusobacterium nucleatum Parvimonas micra, which identified be enriched patients; pathogens such as F. enterotoxigenic Bacteroides fragilis, P. scientists extensively studied; diagnostic nucleatum; therapeutic effects, microecological agents represented by certain Lactobacillus strains, fecal transplantation, traditional medicines Berberine Curcumin. More efforts should focused exploring underlying pathogenesis providing novel preventive strategies.

Language: Английский

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Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer

Journal for ImmunoTherapy of Cancer, Journal Year: 2024, Volume and Issue: 12(3), P. e008054 - e008054

Published: March 1, 2024

Background The effectiveness of immune checkpoint inhibitors in colorectal cancer (CRC) is limited due to the low tumor neoantigen load and infiltration most microsatellite-stable (MSS) tumors. This study aimed develop a mitochondria-targeted photodynamic therapy (PDT) approach provoke host antitumor immunity MSS-CRC elucidate underlying molecular mechanisms. Methods role mechanism PDT inhibiting CRC progression inducing pyroptosis were evaluated both vitro vivo. effects sensitization on PD-1 blockade also assessed CT26 4T1 tumor-bearing mouse models. Results Here, we report that using IR700DX-6T, photosensitizer targeting mitochondrial translocation protein, may trigger an response initiated by CRC. Mechanistically, IR700DX-6T-PDT produced reactive oxygen species light irradiation promoted downstream p38 phosphorylation active caspase3 (CASP3)-mediated cleavage gasdermin E (GSDME), subsequently pyroptosis. Furthermore, enhanced sensitivity cells blockade. Decitabine, demethylation drug used treat hematologic neoplasms, disrupted abnormal methylation pattern GSDME cells, efficacy IR700DX-6T-PDT, elicited potent combination with IR700DX-6T-PDT. Conclusion Our work provides clear understanding immunogenic cell death triggered PDT, offering new for enhancing

Language: Английский

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CSCO guidelines for colorectal cancer version 2022: Updates and discussions

Chinese Journal of Cancer Research, Journal Year: 2022, Volume and Issue: 34(2), P. 67 - 70

Published: Jan. 1, 2022

Language: Английский

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Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

Small, Journal Year: 2023, Volume and Issue: 19(20)

Published: Feb. 17, 2023

Abstract Exosomes are promising new biomarkers for colorectal cancer (CRC) diagnosis, due to their rich biological fingerprints and high level of stability. However, the accurate detection exosomes with specific surface receptors is limited clinical application. Herein, an exosome enrichment platform on a 3D porous sponge microfluidic chip constructed capture efficiency this ≈90%. Also, deep mass spectrometry analysis followed by multi‐level expression screenings revealed CRC‐specific membrane protein (SORL1). A method SORL1 quantum dot labeling further designed ensemble classification system established extracting features from 64‐patched fluorescence images. Importantly, area under curve (AUC) using 0.99, which significantly higher ( p < 0.001) than that conventional biomarker (carcinoembryonic antigen (CEA), AUC 0.71). The above showed similar diagnostic performance, dealing early‐stage CRC, young CEA‐negative CRC patients.

Language: Английский

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Differences in the incidence and mortality of digestive cancer between Global Cancer Observatory 2020 and Global Burden of Disease 2019

International Journal of Cancer, Journal Year: 2023, Volume and Issue: 154(4), P. 615 - 625

Published: Sept. 26, 2023

The burden of digestive cancers is increasing worldwide. Global Cancer Observatory (GLOBOCAN) 2020 and the Burden Disease (GBD) 2019 are two primary cancer databases, which have a significant impact on policy formulation resource allocation. We aim to compare incidence mortality between them. Digestive (esophageal, stomach, colorectal, liver, gallbladder pancreatic cancer) was obtained from Today GBD result tool. top five countries with most or minor difference GLOBOCAN in age-standardized rates (ASIRs) were identified. A systematic search specific selected PubMed Embase conducted, 20 281 publications included. differences commonly found Asian (70%), particularly Indonesia, Vietnam Myanmar, located Southeast Asia. ASIRs for cancers, except liver cancer, higher than those 2019. Gallbladder had highest average ratio, followed by cancer. used standard population Segi's population, World Health Organization population. data sources nor processing methods not similar. Low- middle-income without population-based registries more likely selection bias collection amplify regional variations etiological factors. Better judgments quality can be made.

Language: Английский

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Colorectal Cancer: Current Updates and Future Perspectives

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(1), P. 40 - 40

Published: Dec. 21, 2023

Colorectal cancer is a frequent neoplasm in western countries, mainly due to dietary and behavioral factors. Its incidence growing developing countries for the westernization of foods lifestyles. An increased rate observed patients under 45 years age. In recent years, mortality CRC decreased, but this trend slowing. The reducing those where prevention treatments have been implemented. survival over 65%. This reflects earlier detection through routine clinical examinations screening, more accurate staging advances imaging, improvements surgical techniques, chemotherapy radiation. most important predictor stage at diagnosis. screening programs are able reduce rates CRC. aim paper provide comprehensive overview incidence, mortality,

Language: Английский

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Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: July 21, 2023

The crucial role of intratumoral bacteria in the progression cancer has been gradually recognized with development sequencing technology. Several which have identified as pathogens that induce progression, metastasis, and poor outcome cancer, while tumor vascular networks immunosuppressive microenvironment provide shelters for localization. Thus, mutually-beneficial interplay between tumors, named "pathogen-tumor symbionts", is probably a potential therapeutic site treatment. Herein, we proposed destroying pathogen-tumor symbionts strategy kills pathogens, F. nucleatum, to break symbiont synergize kill colorectal (CRC) cells. This was achieved by groundbreaking protein-supported copper single-atom nanozyme (BSA-Cu SAN) inspired structures native enzymes are based on protein, metal elements active center. BSA-Cu SAN can exert catalytic therapy generating reactive oxygen species (ROS) depleting GSH. vitro vivo experiments demonstrate passively targets sites efficiently scavenges nucleatum situ destroy symbionts. As result, ROS resistance CRC through elevated autophagy mediated relieved, contributing apoptosis cells induced intracellular redox imbalance generated SAN. Particularly, experiences renal clearance, avoiding long-term systemic toxicity. work provides feasible paradigm block antitumor an optimized trail clearable

Language: Английский

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The risk of colorectal cancer according to obesity status at four-year intervals: a nationwide population-based cohort study

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: June 1, 2023

Obesity is a risk factor for colorectal cancer. However, the effect of body weight change on cancer uncertain. This study aimed to investigate relationship between difference in mass index and In this nationwide population-based cohort study, participants national screening program 2005 2009 were enrolled. Difference was calculated from data 2009. Participants divided into four groups according direction obesity status: non-obese/non-obese, non-obese/obese, obese/non-obese, obese/obese. The differences analyzed. Among 3,858,228 participants, 47,894 (1.24%) newly diagnosed with during 9.2 years follow-up. incidence higher obese/obese group than non-obese/non-obese (hazard ratio = 1.08 [1.06-1.11], P trend < 0.001). men had colon women 1.13 [1.10-1.17] men, hazard 1.04 [1.01-1.18] women, Persistent associated

Language: Английский

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Why is early detection of colon cancer still not possible in 2023?

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(3), P. 211 - 224

Published: Jan. 18, 2024

Colorectal cancer (CRC) screening is a fundamental tool in the prevention and early detection of one most prevalent lethal cancers. Over years, screening, particularly those settings where it well organized, has succeeded reducing incidence colon rectal improving prognosis related to them. Despite considerable advancements technologies strategies, effectiveness CRC programs remains less than optimal. This paper examined multifaceted reasons behind persistent lack initiatives. Through critical analysis current methodologies, technological limitations, patient-related factors, systemic challenges, we elucidated complex interplay that hampers successful reduction morbidity mortality rates. While acknowledging have improved aspects emphasized necessity addressing identified barriers comprehensively. study aimed raise awareness how important costs for this disease. Screening diagnosis are not only patients with but can lead an cost treating disease often diagnosed at advanced stage. Spending more sooner mean saving money later.

Language: Английский

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