Research progress on ferroptosis regulation in tumor immunity of hepatocellular carcinoma DOI

Yuqian Mo,

Zhilin Zou, Erbao Chen

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Ferroptosis is a form of regulated cell death, which dependent on iron metabolism imbalance and characterized by lipid peroxidation; it plays crucial role in various pathological processes. Studies have shown that the occurrence ferroptosis closely associated with progression hepatocellular carcinoma (HCC). involved regulating metabolism, homeostasis, mitochondrial redox processes HCC. Additionally, key HCC tumor immunity modulating phenotype function immune cells microenvironment, affecting escape progression. Ferroptosis-induced peroxidation oxidative stress can promote polarization M1 macrophages enhance pro-inflammatory response tumors, inhibiting suppressive such as myeloid-derived suppressor Treg to disrupt their suppression function. The expression regulation ferroptosis-related molecules GPX4 SLC7A11 not only affects sensitivity immunotherapy but also directly influences activity survival effector T dendritic cells, further enhancing or weakening host anti-tumor response. Targeting has demonstrated significant clinical potential treatment. Induction nanomedicine molecular targeting strategies kills enhances antitumor responses. integration multimodal therapies expands application cancer therapy. This article reviews relationship between responses from perspective provide insights for development based ferroptosis.

Language: Английский

Let’s make it personal: CRISPR tools in manipulating cell death pathways for cancer treatment DOI Creative Commons
Mobina Bayat, Javid Sadri Nahand

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: July 29, 2024

Abstract Advancements in the CRISPR technology, a game-changer experimental research, have revolutionized various fields of life sciences and more profoundly, cancer research. Cell death pathways are among most deregulated cells considered as critical aspects development. Through decades, our knowledge mechanisms orchestrating programmed cellular has increased substantially, attributed to revolution cutting-edge technologies. The heroic appearance systems expanded available screening platform genome engineering toolbox detect mutations create precise edits. In that context, ability this system for identification targeting cell signaling result development therapy resistance is an auspicious choice transform accelerate individualized therapy. concept personalized stands on molecular characterization individual tumor its microenvironment order provide treatment with highest possible outcome minimum toxicity. This study explored potential technology precision by identifying specific pathways. It showed promise finding key components involved death, making it tool targeted However, also highlighted challenges limitations need be addressed future research fully realize treatment. Graphical abstract Current application through glance. A choosing appropriate biological model vitro (using established lines, animal derived cells, human stem or T cells), vivo models which can harbor tumor), ex (human/animal-derived organoids). B preparation gRNA library. C design screening, desired gRNAs phenotypic response. D CRISPR-Cas identified targets, Cas9 gene editing (Knockout, base editing, prime editing), RNA modulation (modulation splicing, interference), epigenomic edits interference/activation using dead (dCas9) (Bock et al. 2022b)

Language: Английский

Citations

7
Ferroptosis and myocardial ischemia-reperfusion: mechanistic insights and new therapeutic perspectives DOI Creative Commons

Binwei Jin,

Zhiming Zhang,

Yang Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 1, 2024

Myocardial ischemia-reperfusion injury (MIRI) is a significant factor in the development of cardiac dysfunction following myocardial infarction. Ferroptosis, type regulated cell death driven by iron and marked lipid peroxidation, has garnered growing interest for its crucial involvement pathogenesis MIRI.This review comprehensively examines mechanisms ferroptosis, focusing on regulation through metabolism, VDAC signaling, antioxidant system dysregulation. We also compare ferroptosis with other forms to highlight distinct characteristics. Furthermore, MIRI examined focus recent discoveries concerning ROS generation, mitochondrial impairment, autophagic processes, ER stress, non-coding RNA regulation. Lastly, emerging therapeutic strategies that inhibit mitigate are reviewed, providing new insights into potential clinical applications.

Language: Английский

Citations

5
Targeting Ferroptosis in Rare Neurological Disorders Including Pediatric Conditions: Innovations and Therapeutic Challenges DOI Creative Commons
Ahmed D. Alatawi, Krishnaraju Venkatesan,

Khalid A. Asseri

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 265 - 265

Published: Jan. 22, 2025

Ferroptosis, characterized by iron dependency and lipid peroxidation, has emerged as a key mechanism underlying neurodegeneration in rare neurological disorders. These conditions, often marked significant therapeutic gaps high unmet medical needs, present unique challenges for intervention development. This review examines the involvement of ferroptosis disease pathogenesis, focusing on its role oxidative damage neuronal dysfunction. We explore recent pharmacological advancements, including chelators, peroxidation blockers, antioxidant-based strategies, designed to target ferroptosis. While these approaches show promise, such heterogeneity, limited diagnostic tools, small patient cohorts hinder progress. Furthermore, we discuss translational regulatory barriers implementing ferroptosis-based therapies clinical practice. By addressing obstacles fostering innovative solutions, this underscores potential ferroptosis-targeting strategies revolutionize treatment paradigms

Language: Английский

Citations

0
The Intersections between Neuroscience and Medulloblastoma DOI
Yafei Wang, Ying Yu, Jiahua Yu

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217660 - 217660

Published: March 1, 2025

Language: Английский

Citations

0
Glutathione Metabolism in Ferroptosis and Cancer Therapy DOI
Xiangfei Xue, Manyuan Wang,

Jiangtao Cui

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217697 - 217697

Published: April 1, 2025

Language: Английский

Citations

0
SIK1 promotes ferroptosis resistance in pancreatic cancer via HDAC5-STAT6-SLC7A11 axis DOI
Hao Zhang, Tao Ma,

Xiaofeng Wen

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217726 - 217726

Published: April 1, 2025

Language: Английский

Citations

0
RPS21 Enhances hepatocellular carcinoma development through GPX4 stabilization DOI
Siyuan Wu, Gaochao Wang, Liankun Gu

et al.

Translational Oncology, Journal Year: 2024, Volume and Issue: 51, P. 102189 - 102189

Published: Nov. 14, 2024

Language: Английский

Citations

0
Research progress on ferroptosis regulation in tumor immunity of hepatocellular carcinoma DOI

Yuqian Mo,

Zhilin Zou, Erbao Chen

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Ferroptosis is a form of regulated cell death, which dependent on iron metabolism imbalance and characterized by lipid peroxidation; it plays crucial role in various pathological processes. Studies have shown that the occurrence ferroptosis closely associated with progression hepatocellular carcinoma (HCC). involved regulating metabolism, homeostasis, mitochondrial redox processes HCC. Additionally, key HCC tumor immunity modulating phenotype function immune cells microenvironment, affecting escape progression. Ferroptosis-induced peroxidation oxidative stress can promote polarization M1 macrophages enhance pro-inflammatory response tumors, inhibiting suppressive such as myeloid-derived suppressor Treg to disrupt their suppression function. The expression regulation ferroptosis-related molecules GPX4 SLC7A11 not only affects sensitivity immunotherapy but also directly influences activity survival effector T dendritic cells, further enhancing or weakening host anti-tumor response. Targeting has demonstrated significant clinical potential treatment. Induction nanomedicine molecular targeting strategies kills enhances antitumor responses. integration multimodal therapies expands application cancer therapy. This article reviews relationship between responses from perspective provide insights for development based ferroptosis.

Language: Английский

Citations

0