Biomaterials for Corneal Regeneration DOI Creative Commons
Yimeng Li, Zhengke Wang

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract Corneal blindness is a significant reason for visual impairment globally. Researchers have been investigating several methods corneal regeneration in order to cure these patients. Biomaterials are favored due their biocompatibility and capacity promote cell adhesion. A variety of natural synthetic biomaterials, along with decellularized cornea, employed wound healing. Commonly utilized biomaterials encompass proteins such as collagen, gelatin, silk fibroin (SF), well polysaccharides including alginate, chitosan (CS), hyaluronic acid (HA), cellulose. Synthetic primarily consist polyvinyl alcohol (PVA), poly(ε‐caprolactone) (PCL), poly (lactic‐co‐glycolic acid) (PLGA). Bio‐based materials composites hydrogels, films, scaffolds, patches, nanocapsules, other formats the treatment blinding ocular conditions, wounds, ulcers, endothelium, stromal defects. This review attempts summarize vitro, preclinical, clinical trial studies relevant using within last five years, expect that experiences outcomes will inspire provide practical strategies future development regeneration. Furthermore, potential improvements difficulties discussed.

Language: Английский

Nanocellulose-based hydrogels as versatile materials with interesting functional properties for tissue engineering applications DOI Creative Commons
Arnaud Kamdem Tamo

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(32), P. 7692 - 7759

Published: Jan. 1, 2024

Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.

Language: Английский

Citations

24
Nanocellulose-Based Hybrid Scaffolds for Skin and Bone Tissue Engineering: A 10-Year Overview DOI

Mridula Sreedharan,

Raji Vijayamma,

Elena V. Liyaskina

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(4), P. 2136 - 2155

Published: March 6, 2024

Cellulose, the most abundant polymer on Earth, has been widely utilized in its nanoform due to excellent properties, finding applications across various scientific fields. As demand for nanocellulose continues rise and ease of use becomes apparent, there a significant increase research publications centered this biomaterial. Nanocellulose, different forms, shown tremendous promise as tissue engineered scaffold regeneration repair. Particularly, nanocellulose-based composites scaffolds have emerged highly demanding materials both soft hard engineering. Medical practitioners traditionally relied collagen analogue, gelatin, treating damage. However, limited mechanical strength these biopolymers restricts their direct applications. This issue can be overcome by making hybrids with nanocellulose. review presents comprehensive analysis recent relevant focusing hybrid gelatin specific emphasis combination While bone skin engineering represents two areas where majority researchers are concentrating efforts, highlights contexts.

Language: Английский

Citations

18
Nanocellulose Extraction from Biomass Waste: Unlocking Sustainable Pathways for Biomedical Applications DOI Creative Commons
Mehrdad Ghamari,

Suvish,

Chan Hwang See

et al.

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract The escalating global waste crisis necessitates innovative solutions. This study investigates the sustainable production of nanocellulose from biomass and its biomedical applications. Cellulose‐rich materials–including wood, textiles, agricultural residues, food by‐products–were systematically processed using alkaline, acid, oxidative pretreatments to enhance fiber accessibility. Mechanical techniques, such as grinding homogenization, combined with chemical methods like acid hydrolysis 2,2,6,6‐Tetramethylpiperidin‐1‐yl‐oxyl (TEMPO) oxidation, were employed successfully isolate nanocellulose. Post‐treatment modifications, including surface coating cross‐linking, further tailored properties for specific results demonstrated nanocellulose's biocompatibility, biodegradability, functional versatility. In wound healing, it enhanced moisture management exhibited antimicrobial properties. Its high area facilitated efficient drug loading controlled release in delivery Nanocellulose bioinks supported cell proliferation 3D bioprinting tissue engineering. Additional applications biosensors personal care products also identified. advances materials science, aligning resource conservation circular economy principles address sector needs.

Language: Английский

Citations

2
Nanocellulose: Recent Advances Toward Biomedical Applications DOI Creative Commons
Xuan-Ran Ong,

Adrielle Xianwen Chen,

Ning Li

et al.

Small Science, Journal Year: 2022, Volume and Issue: 3(2)

Published: Dec. 22, 2022

Sustainable materials are key to the continual improvement of living standards on this planet with minimal environmental impacts. Nanocellulose combines fascinating features nanomaterials favorable properties abundantly available cellulose biopolymer, which in recent years has gained much attention toward biomedical applications by virtue its unique surface chemistry, remarkable physical features, and inherent biological attributes. Herein, advances nanocellulose‐based materials, foci biomolecule immobilization, drug delivery, cell culture tissue engineering (TE), antimicrobial strategy, wound healing, implants summarized. Each topic is elaborated representative examples present significance nanocelluloses their respective material design principles utilizing different sub‐types, including nanofibers (CNFs), nanocrystals (CNCs), bacterial nanocellulose (BNC). The current state large‐scale production accelerated development artificial intelligence machine learning also briefly discussed, before ending future prospects potential challenges.

Language: Английский

Citations

48
Recent advances in 3D printed cellulose-based wound dressings: A review on in vitro and in vivo achievements DOI Creative Commons
Maria Pita‐Vilar, Ángel Concheiro, Carmen Alvarez‐Lorenzo

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 321, P. 121298 - 121298

Published: Aug. 14, 2023

Chronic wounds, especially diabetic ulcers, pose a significant challenge in regenerative medicine. Cellulose derivatives offer remarkable wound management properties, such as effective absorption and retention of exudates, maintaining an optimal moisture environment crucial for successful chronic regeneration. However, conventional dressings have limited efficacy managing healing these types skin lesions, driving scientists to explore innovative approaches. The emergence 3D printing has enabled personalized that meet individual patient needs, improving the process comfort. demanding requirements biocompatibility, printability, biofabrication necessary biologically active scaffolds. potential applications nanocellulose cellulose derivative-based inks regeneration remain largely unexplored. Thus, this review provides comprehensive overview recent advancements cellulose-based dressings. composition approaches are thoroughly discussed, including functionalization with bioactive molecules antibiotics improved Similarly, vitro vivo performance is extensively examined. In summary, aims highlight exceptional advantages diverse printed care.

Language: Английский

Citations

35
Chitosan-Based Electrochemical Sensors for Pharmaceuticals and Clinical Applications DOI Open Access
Alexandra Virginia Bounegru, Iulian Bounegru

Polymers, Journal Year: 2023, Volume and Issue: 15(17), P. 3539 - 3539

Published: Aug. 25, 2023

Chitosan (CTS), a biocompatible and multifunctional material derived from chitin, has caught researchers’ attention in electrochemical detection due to its unique properties. This review paper provides comprehensive overview of the recent progress applications CTS-based sensors analysis pharmaceutical products other types samples, with particular focus on medicinal substances. The covers studies developments 2003 2023, highlighting remarkable properties CTS, such as biocompatibility, chemical versatility, large surface area, that make it an excellent candidate for sensor modification. Combining CTS various nanomaterials significantly enhances capabilities sensors. Various are analyzed, including those utilizing carbon nanomaterials, metallic nanoparticles, conducting polymers, molecularly imprinted CTS. These exhibit sensitivity, selectivity, stability, enabling precise reliable medications. manufacturing strategies used preparation described, underlying mechanisms elucidated, integration transducer systems is highlighted. prospects promising, opportunities miniaturization, simultaneous detection, real-time monitoring applications.

Language: Английский

Citations

35
Cellulose nanocrystals for crop protection: leaf adhesion and controlled delivery of bioactive molecules DOI
Like Ning, Chaoqun You,

Yuxin Jia

et al.

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(7), P. 2690 - 2698

Published: Jan. 1, 2023

TA/Cu-XCM@βCNC nanocarrier is developed for crop protection, the introduced system enables pH-responsive controlled delivery, enhances deposition and prevents pesticide leakage.

Language: Английский

Citations

33
Current advances of nanocellulose application in biomedical field DOI

Moong Yan Leong,

Y.L. Kong,

M.Y. Harun

et al.

Carbohydrate Research, Journal Year: 2023, Volume and Issue: 532, P. 108899 - 108899

Published: July 17, 2023

Language: Английский

Citations

29
Biosafety consideration of nanocellulose in biomedical applications: A review DOI
Yan Li, Haixin Jiao, Hong‐Xing Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130900 - 130900

Published: March 16, 2024

Language: Английский

Citations

16
Catalytic and biomedical applications of nanocelluloses: A review of recent developments DOI Creative Commons
Danial Khorsandi,

Serena Jenson,

Atefeh Zarepour

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131829 - 131829

Published: April 25, 2024

Nanocelluloses exhibit immense potential in catalytic and biomedical applications. Their unique properties, biocompatibility, versatility make them valuable various industries, contributing to advancements environmental sustainability, catalysis, energy conversion, drug delivery, tissue engineering, biosensing/imaging, wound healing/dressings. Nanocellulose-based catalysts can efficiently remove pollutants from contaminated environments, sustainable cleaner ecosystems. These materials also be utilized as carriers, enabling targeted controlled release. high surface area allows for efficient loading of therapeutic agents, while their biodegradability ensures safer gradual release within the body. delivery systems enhance efficacy treatments minimizes side effects. Moreover, nanocelluloses serve scaffolds engineering due structural integrity biocompatibility. They provide a three-dimensional framework cell growth regeneration, promoting development functional biologically relevant tissues. dressings have shown great promise healing dressings. ability absorb exudates, maintain moist environment, promote proliferation migration accelerates process. Herein, recent pertaining applications composites are deliberated, focusing on important challenges, advantages, limitations, future prospects.

Language: Английский

Citations

9