ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(7), P. 2725 - 2737
Published: June 21, 2023
The
conventional
pectin
delivery
systems
in
the
colon
are
often
impaired
by
a
slow
release
rate.
Nanostructured
particles,
especially
porous
ones,
have
gained
popularity
as
drug
owing
to
their
high
mass
transfer
efficiency.
In
this
research,
particles
were
synthesized
carriers
(using
indomethacin
model
drug)
via
template-assisted
spray
drying.
Specific
surface
areas
of
been
improved
up
203
m2
g-1
compared
with
nonporous
(1
g-1).
structure
shortened
diffusion
path
and
rate
molecules.
Additionally,
predominant
mechanism
from
is
Fickian
diffusion,
which
different
combination
erosion
observed
for
particles.
As
result,
these
drug-loaded
demonstrated
rapid
rates
three
times
faster
than
Control
could
be
achieved
changing
This
strategy
an
efficient
means
synthesize
allowing
into
colonic
target.
Gels,
Journal Year:
2022,
Volume and Issue:
8(7), P. 393 - 393
Published: June 21, 2022
Chitosan,
a
copolymer
of
glucosamine
and
N-acetyl
glucosamine,
is
derived
from
chitin.
Chitin
found
in
cell
walls
crustaceans,
fungi,
insects
some
algae,
microorganisms,
invertebrate
animals.
Chitosan
emerging
as
very
important
raw
material
for
the
synthesis
wide
range
products
used
food,
medical,
pharmaceutical,
health
care,
agriculture,
industry,
environmental
pollution
protection.
This
review,
line
with
focus
this
special
issue,
provides
reader
(1)
an
overview
on
different
sources
chitin,
(2)
advances
techniques
to
extract
chitin
converting
it
into
chitosan,
(3)
importance
inherent
characteristics
chitosan
that
makes
them
suitable
specific
applications
and,
finally,
(4)
briefly
summarizes
ways
tailoring
applications.
The
review
also
presents
influence
degree
acetylation
(DA)
deacetylation
(DDA),
molecular
weight
(Mw)
physicochemical
biological
properties
acid-base
behavior,
biodegradability,
solubility,
reactivity,
among
many
other
determine
processability
suitability
intended
help
guide
researchers
select
right
their
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 807 - 807
Published: March 1, 2023
Chitosan
is
a
chitin-derived
biopolymer
that
has
shown
great
potential
for
tissue
regeneration
and
controlled
drug
delivery.
It
numerous
qualities
make
it
attractive
biomedical
applications
such
as
biocompatibility,
low
toxicity,
broad-spectrum
antimicrobial
activity,
many
others.
Importantly,
chitosan
can
be
fabricated
into
variety
of
structures
including
nanoparticles,
scaffolds,
hydrogels,
membranes,
which
tailored
to
deliver
desirable
outcome.
Composite
chitosan-based
biomaterials
have
been
demonstrated
stimulate
in
vivo
the
repair
various
tissues
organs,
but
not
limited
to,
bone,
cartilage,
dental,
skin,
nerve,
cardiac,
other
tissues.
Specifically,
de
novo
formation,
resident
stem
cell
differentiation,
extracellular
matrix
reconstruction
were
observed
multiple
preclinical
models
different
injuries
upon
treatment
with
formulations.
Moreover,
proven
efficient
carriers
medications,
genes,
bioactive
compounds
since
they
maintain
sustained
release
these
therapeutics.
In
this
review,
we
discuss
most
recently
published
organ
well
delivery
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 4727 - 4750
Published: Aug. 1, 2023
Conventional
nanoparticle
synthesis
methods
involve
harsh
conditions,
high
costs,
and
environmental
pollution.
In
this
context,
researchers
are
actively
searching
for
sustainable,
eco-friendly
alternatives
to
conventional
chemical
methods.
This
has
led
the
development
of
green
procedures
among
which
exploration
plant-mediated
nanoparticles
experienced
a
great
development.
Especially,
because
plant
extracts
can
work
as
reducing
stabilizing
agents.
opens
up
new
possibilities
cost-effective,
environmentally-friendly
with
enhanced
size
uniformity
stability.
Moreover,
bio-inspired
derived
from
plants
exhibit
intriguing
pharmacological
properties,
making
them
highly
promising
use
in
medical
applications
due
their
biocompatibility
nano-dimension.This
study
investigates
role
specific
phytochemicals,
such
phenolic
compounds,
terpenoids,
proteins,
together
influence
on
particle
size,
stability,
properties.
Additionally,
we
highlight
potential
these
bio-derived
nanoparticles,
particularly
regard
drug
delivery,
disease
management,
agriculture,
bioremediation,
application
other
industries.Extensive
research
scientific
databases
identified
methods,
specifically
synthesis,
focus
understanding
contributions
phytochemicals
like
proteins.
The
database
search
covered
field's
over
past
15
years.Insights
gained
cost-effective
production
significant
Utilizing
renewable
biological
resources
controlling
characteristics
through
biomolecule
interactions
offer
avenues
future
applications.This
review
delves
into
intricacies
highlighting
advantages
approach
traditional
showcases
immense
applications,
aiming
inspire
further
exciting
area
promote
more
sustainable
future.
Marine Drugs,
Journal Year:
2022,
Volume and Issue:
20(5), P. 335 - 335
Published: May 20, 2022
Chitosan
(CS)
is
a
linear
polysaccharide
obtained
by
the
deacetylation
of
chitin,
which,
after
cellulose,
second
biopolymer
most
abundant
in
nature,
being
primary
component
exoskeleton
crustaceans
and
insects.
Since
joining
pharmaceutical
field,
early
1990s,
CS
attracted
great
interest,
which
has
constantly
increased
over
years,
due
to
its
several
beneficial
favorable
features,
including
large
availability,
biocompatibility,
biodegradability,
non-toxicity,
simplicity
chemical
modifications,
mucoadhesion
permeation
enhancer
power,
joined
capability
forming
films,
hydrogels
micro-
nanoparticles.
Moreover,
cationic
character,
renders
it
unique
among
biodegradable
polymers,
responsible
for
ability
strongly
interact
with
different
types
molecules
intrinsic
antimicrobial,
anti-inflammatory
hemostatic
activities.
However,
pH-dependent
solubility
susceptibility
ions
presence
may
represent
serious
drawbacks
require
suitable
strategies
be
overcome.
Presently,
derivatives
are
widely
investigated
variety
applications,
particularly
drug
delivery.
Among
alternative
routes
overcome
problems
related
classic
oral
administration,
mucosal
route
becoming
favorite
non-invasive
delivery
pathway.
This
review
aims
provide
an
updated
overview
applications
novel
formulations
intended
methods
Journal of Materials Chemistry B,
Journal Year:
2022,
Volume and Issue:
10(31), P. 5853 - 5872
Published: Jan. 1, 2022
As
a
group
of
chronic
and
idiopathic
gastrointestinal
(GI)
disorders,
inflammatory
bowel
disease
(IBD)
is
characterized
by
recurrent
intestinal
mucosal
inflammation.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Aug. 18, 2023
Due
to
oral
nano-delivery
systems
for
the
treatment
of
inflammatory
bowel
disease
(IBD)
are
often
failed
accumulated
colonic
site
and
could
not
achieve
controlled
drug
release,
it's
urgent
develop
a
microenvironment
responsive
delivery
improve
therapy
efficacy.
Inflammation
at
IBD
is
mainly
mediated
by
macrophages,
which
key
effector
cells.
Excessive
inflammation
leads
oxidative
stress
intestinal
mucosal
damage.
The
use
curcumin
(CUR)
emodin
(EMO)
together
promising
due
their
respective
anti-inflammatory
repair
effects.
In
view
pH
gradient
environment
gastrointestinal
tract,
here
we
prepared
pH-responsive
sodium
alginate
(SA)
hydrogel-coated
nanoemulsions
co-deliver
CUR
EMO
(CUR/EMO
NE@SA)
release
specifically
target
macrophages
colon.In
this
study,
CUR/EMO
NE@SA
was
successfully
developed,
in
NE
loaded
chitosan
further
crosslinked
with
alginate.
had
property
colon.
preparation
significantly
alleviate
colon
decreasing
TNF-α
IL-6
expression,
increasing
IL-10
scavenging
reactive
oxygen
species
ameliorating
restoration
tight
junction
protein
expression.
Furthermore,
revealed
molecular
mechanism
treatment,
might
synergic
inhibition
NF-κB
pro-inflammatory
microenvironment.
Our
study
provides
new
strategy
via
synergically
inhibiting
inflammatory,
repairing
clearing
ROS
pH-sensitive
hydrogel-encapsulated
nanoemulsion
system,
be
developed
other
chronic
treatment.It's
suggested
that
nanoemulsion-based
codelivery
combinatorial
platform
IBD.
