Advances in nanomaterial-based targeted drug delivery systems

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: April 13, 2023

Nanomaterial-based drug delivery systems (NBDDS) are widely used to improve the safety and therapeutic efficacy of encapsulated drugs due their unique physicochemical biological properties. By combining with nanoparticles using rational targeting pathways, nano-targeted were created overcome main drawbacks conventional treatment, including insufficient stability solubility, lack transmembrane transport, short circulation time, undesirable toxic effects. Herein, we reviewed recent developments in different design strategies approaches employing various nanomaterial-based systems. We also discussed challenges perspectives smart precisely intravascular extravascular diseases.

Language: Английский

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Mechanisms of Nanoparticle Transport across Intestinal Tissue: An Oral Delivery Perspective

ACS Nano, Journal Year: 2023, Volume and Issue: 17(14), P. 13044 - 13061

Published: July 6, 2023

Oral drug administration has been a popular choice due to patient compliance and limited clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) environment effectively enter systemic circulation. The GI tract number of structural physiological barriers that limit bioavailability including mucus, tightly regulated epithelial layer, immune cells, associated vasculature. Nanoparticles have used enhance oral drugs, as they can act shield prevent early degradation while also increasing uptake transport across intestinal epithelium. Evidence suggests different nanoparticle formulations may be transported via intracellular mechanisms cross Despite existence significant body work on nanoparticles, many key questions remain: What causes poor drugs? factors contribute ability barriers? Do properties such size charge influence type endocytic pathways taken? In this Review, we summarize components types nanoparticles developed for delivery. particular, focus various in internalization or cargo translocation Understanding gut barrier, characteristics, lead development more therapeutically useful carriers.

Language: Английский

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Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: March 29, 2023

Abstract Background The past few years have witnessed a significant increase in research related to plant-derived extracellular vesicles (PDEVs) biological and medical applications. Using biochemical technologies, multiple independent groups demonstrated the important roles of PDEVs as potential mediators involved cell-cell communication exchange bio-information between species. Recently, several contents been well identified PDEVs, including nucleic acids, proteins, lipids, other active substances. These cargoes carried by could be transferred into recipient cells remarkably influence their behaviors associated with human diseases, such cancers inflammatory diseases. Main body abstract This review summarizes latest updates regarding focuses on its role nanomedicine applications, drug delivery strategies develop diagnostic therapeutic agents for clinical management especially like cancers. Conclusion Considering unique advantages, high stability, intrinsic bioactivity easy absorption, further elaboration molecular mechanisms factors driving function will provide new horizons treatment disease.

Language: Английский

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Responsively Degradable Nanoarmor‐Assisted Super Resistance and Stable Colonization of Probiotics for Enhanced Inflammation‐Targeted Delivery

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 19, 2024

Manipulation of the gut microbiota using oral microecological preparations has shown great promise in treating various inflammatory disorders. However, delivering these while maintaining their disease-site specificity, stability, and therapeutic efficacy is highly challenging due to dynamic changes associated with pathological microenvironments gastrointestinal tract. Herein, a superior armored probiotic an inflammation-targeting capacity developed enhance timely action bacterial therapy against bowel disease (IBD). The coating strategy exhibits suitability for diverse strains negligible influence on viability. This study demonstrates that probiotics have ultraresistance extreme intraluminal conditions stable mucoadhesive capacity. Notably, HA-functionalized nanoarmor equips inflamed-site targetability through multiple interactions, thus enhancing IBD therapy. Moreover, "awakening" ingested responsive transferrin-directed degradation at site inflammation beneficial therapy, which requires cells be fully functional. Given its easy preparation favorable biocompatibility, single-cell approach provides effective advanced delivery biomedical applications cellular level.

Language: Английский

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Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24

Published: Jan. 14, 2025

Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.

Language: Английский

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Nanomaterials for mRNA‐based therapeutics: Challenges and opportunities

Bioengineering & Translational Medicine, Journal Year: 2023, Volume and Issue: 8(3)

Published: Jan. 29, 2023

Abstract Messenger RNA (mRNA) holds great potential in developing immunotherapy, protein replacement, and genome editing. In general, mRNA does not have the risk of being incorporated into host need to enter nucleus for transfection, it can be expressed even nondividing cells. Therefore, mRNA‐based therapeutics provide a promising strategy clinical treatment. However, efficient safe delivery remains crucial constraint application therapeutics. Although stability tolerability enhanced by directly retouching structure, there is still an urgent improve mRNA. Recently, significant progress has been made nanobiotechnology, providing tools nanocarriers. Nano‐drug system used loading, protecting, releasing biological microenvironment stimulate translation develop effective intervention strategies. present review, we summarized concept emerging nanomaterials latest enhancing function mRNA, primarily focusing on role exosomes delivery. Moreover, outlined its applications so far. Finally, key obstacles nanocarriers are emphasized, strategies overcome these proposed. Collectively, nano‐design materials exert functions specific applications, new perception next‐generation nanomaterials, thus revolution technology.

Language: Английский

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Emerging role of bacterial outer membrane vesicle in gastrointestinal tract

Gut Pathogens, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 27, 2023

Bacteria form a highly complex ecosystem in the gastrointestinal (GI) tract. In recent years, mounting evidence has shown that bacteria can release nanoscale phospholipid bilayer particles encapsulate nucleic acids, proteins, lipids, and other molecules. Extracellular vesicles (EVs) are secreted by microorganisms transport variety of important factors, such as virulence antibiotics, HGT, defensive factors produced host eukaryotic cells. addition, these EVs vital facilitating communication between microbiota host. Therefore, bacterial play crucial role maintaining GI tract's health proper functioning. this review, we outlined structure composition EVs. Additionally, highlighted critical immune regulation balance gut microbiota. To further elucidate progress field intestinal research to provide reference for future EV studies, also discussed clinical pharmacological potential EVs, well necessary efforts required understand mechanisms interaction pathogenesis.

Language: Английский

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Oral Nanotherapeutics of Andrographolide/Carbon Monoxide Donor for Synergistically Anti-inflammatory and Pro-resolving Treatment of Ulcerative Colitis

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(30), P. 36061 - 36075

Published: July 18, 2023

Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology affecting the colon and rectum. Current therapeutics are focused on suppressing inflammation but ineffective. Combining anti-inflammatory therapeutic approaches with pro-resolution might be superior strategy for UC treatment. Andrographolide (AG), an active compound from plant Andrographis paniculata, presented effects in various diseases. Gaseous mediators, such as carbon monoxide (CO), have role resolution. Herein, we developed dextran-functionalized PLGA nanocarrier efficient delivery AG donor (CORM-2) synergistically anti-inflammatory/pro-resolving treatment (AG/CORM-2@NP-Dex) based good biocompatibility, slow drug release, targeting, biodegradability. The resulting had nano-scaled diameter ∼200 nm spherical shape. After being coated dextran (Dex), AG/CORM-2@NP-Dex could efficiently internalized by Colon-26 Raw 264.7 cells vitro preferentially localized to inflamed chitosan/alginate hydrogel protection gavage. performed eliminating over-production pro-inflammatory mediator, nitric oxide (NO), down-regulating expression cytokines (TNF-α, IL-1β IL-6), while it showed pro-resolving function accelerating M1 M2 macrophage conversion up-regulating resolution-related genes (IL-10, TGF-β, HO-1). In model, oral administration also effects, therefore relieving effectively. Without appreciable systemic toxicity, this bifunctional represents novel approach expected achieve long-term remission.

Language: Английский

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Stem cell-derived intestinal organoids: a novel modality for IBD

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: July 21, 2023

Abstract The organoids represent one of the greatest revolutions in biomedical field past decade. This three-dimensional (3D) micro-organ cultured vitro has a structure highly similar to that tissue and organ. Using regeneration ability stem cells, 3D organ-like called intestinal is established, which can mimic characteristics real organs, including morphology, function, personalized response specific stimuli. Here, we discuss current cell-based models, understanding molecular pathophysiology, high-throughput screening drugs, drug efficacy testing, toxicological evaluation, organ-based inflammatory bowel disease (IBD). We summarize advances limitations state-of-the-art reconstruction platforms for organoids. challenges, advantages, prospects organs as an model system precision medicine are also discussed.

Language: Английский

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Medicinal plant-based drug delivery system for inflammatory bowel disease

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 23, 2023

Inflammatory bowel disease (IBD) is a chronic recurrent intestinal disease. The incidence rate of IBD increasing year by year, which seriously endangers human health worldwide. More and more studies have shown that medicinal plants or their main phytochemicals great potential in the treatment diseases. However, disadvantages low oral absorption rate, biological distribution systemic bioavailability limit clinical application to certain extent. In recent years, nanotechnology has made it possible treat IBD. Nanoparticles (NPs) drug delivery system attracted special attention due its small size, immunogenicity, surface modification diversity, targeting other advantages. Synthetic nanoparticles extracellular vehicles (EVs) can deliver components colon, play role anti-inflammation, regulation oxidative stress, improvement flora, etc. addition, some secrete EVs themselves, carry molecules with therapeutic effects act on intestine. Some trials evaluate safety, tolerance, toxicity effectiveness EVs-loaded drugs are also progressing steadily. This review introduces synthetic derived an important carrying effective active plants, discuss limitations current research future needs, providing scientific reliable basis perspective for further promotion.

Language: Английский

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