Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
36(12), P. 6114 - 6129
Published: June 3, 2024
Wound
healing
is
a
prolonged
physiological
process
involving
series
of
complicated
biological
responses
influenced
by
various
factors,
such
as
bacterial
infection
and
oxidative
damage.
Existing
treatments,
while
effective,
have
certain
limitations
in
terms
biocompatibility,
responsiveness
to
the
wound
environment,
efficacy
promoting
tissue
regeneration.
To
address
these
shortcomings,
bioinspired
hydration
lubrication
mechanism
articular
cartilage,
we
successfully
designed
developed
an
injectable
situ
photo-cross-linkable
hydrogel,
which
was
synthesized
via
modifying
aminated
hyaluronic
acid
with
polymer
obtained
free
radical
polymerization
o-nitrobenzyl
alcohol
derivative
(NB)
2-methoxyethyl
phosphocholine
(MPC).
The
hydrophilic
layer
formed
around
zwitterionic
charges
MPC
endowed
hydrogel
enhanced
antimicrobial
effects,
whereas
hydroxymethyl
group
NB
enabled
ultraviolet
light-induced
cross-linking
property.
doped
polydopamine
nanoparticles,
facilitated
multifaceted
photothermally
responsive
antibacterial,
anti-inflammation,
angiogenesis.
Specifically,
upon
injection
precursor
solution
into
site
exposure
light,
cross-linked
adhered
closely
skin
tissues,
achieving
hemostasis
exudate
absorption.
Additionally,
showed
excellent
reactive
oxygen
species
scavenging
property,
reducing
cellular
stress
meanwhile
bactericidal
effect
near-infrared
light
irradiation.
Furthermore,
its
networked
porous
structure,
conducive
cell
adhesion
proliferation,
remarkably
enhancing
activity
wound-healing
performances
were
investigated
both
vitro
vivo
experiments,
showcasing
potential
for
treatment
applications,
offering
promising
improvement
over
current
methods
providing
photothermal
responsive,
biocompatible,
effective
process.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(15), P. 3023 - 3023
Published: July 26, 2022
Nowadays,
there
are
still
numerous
challenges
for
well-known
biomedical
applications,
such
as
tissue
engineering
(TE),
wound
healing
and
controlled
drug
delivery,
which
must
be
faced
solved.
Hydrogels
have
been
proposed
excellent
candidates
these
they
promising
properties
the
mentioned
including
biocompatibility,
biodegradability,
great
absorption
capacity
tunable
mechanical
properties.
However,
depending
on
material
or
manufacturing
method,
resulting
hydrogel
may
not
up
to
specific
task
it
is
designed,
thus
different
approaches
enhance
performance
requirements
of
application
in
question.
The
main
purpose
this
review
article
was
summarize
most
recent
trends
technology,
going
through
used
polymeric
materials
popular
synthesis
methods
years,
strategies
enhancing
hydrogels'
properties,
cross-linking
manufacture
composite
hydrogels.
In
addition,
secondary
objective
briefly
discuss
other
novel
applications
hydrogels
that
past
few
years
drawn
a
lot
attention.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 13, 2023
Abstract
The
healing
of
diabetic
wounds
is
hindered
by
various
factors,
including
bacterial
infection,
macrophage
dysfunction,
excess
proinflammatory
cytokines,
high
levels
reactive
oxygen
species,
and
sustained
hypoxia.
These
factors
collectively
impede
cellular
behaviors
the
process.
Consequently,
this
review
presents
intelligent
hydrogels
equipped
with
multifunctional
capacities,
which
enable
them
to
dynamically
respond
microenvironment
accelerate
wound
in
ways,
stimuli
‐responsiveness,
injectable
self‐healing,
shape
‐memory,
conductive
real‐time
monitoring
properties.
relationship
between
multiple
functions
also
discussed.
Based
on
wounds,
antibacterial,
anti‐inflammatory,
immunomodulatory,
antioxidant,
pro‐angiogenic
strategies
are
combined
hydrogels.
application
repair
systematically
discussed,
aiming
provide
guidelines
for
fabricating
exploring
role
therapeutic
processes.
Biomaterials Science,
Journal Year:
2022,
Volume and Issue:
10(15), P. 4058 - 4076
Published: Jan. 1, 2022
Multifunctional
wound
dressings
or
smart
with
pro-angiogenic
function,
antibacterial
properties,
anti-inflammatory/antioxidant
activity
and
tissue
adhesion
for
chronic
repair.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(17)
Published: April 19, 2023
Chronic
wounds
in
diabetic
patients
are
challenging
because
their
prolonged
inflammation
makes
healing
difficult,
thus
burdening
patients,
society,
and
health
care
systems.
Customized
dressing
materials
needed
to
effectively
treat
such
that
vary
shape
depth.
The
continuous
development
of
3D-printing
technology
along
with
artificial
intelligence
has
increased
the
precision,
versatility,
compatibility
various
materials,
providing
considerable
potential
meet
abovementioned
needs.
Herein,
functional
inks
comprising
DNA
from
salmon
sperm
DNA-induced
biosilica
inspired
by
marine
sponges,
developed
for
machine
learning-based
wound
dressings.
biomineralized
silica
incorporated
into
hydrogel
a
fast,
facile
manner.
3D-printed
generates
provided
appropriate
porosity,
characterized
effective
exudate
blood
absorption
at
sites,
mechanical
tunability
indicated
good
fidelity
printability
during
optimized
3D
printing.
Moreover,
act
as
nanotherapeutics,
enhancing
biological
activity
dressings
terms
reactive
oxygen
species
scavenging,
angiogenesis,
anti-inflammation
activity,
thereby
accelerating
acute
healing.
These
bioinspired
hydrogels
produce
using
biomineralization
strategy
an
excellent
platform
clinical
applications
chronic
repair.
