Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(12), P. 6114 - 6129

Published: June 3, 2024

Wound healing is a prolonged physiological process involving series of complicated biological responses influenced by various factors, such as bacterial infection and oxidative damage. Existing treatments, while effective, have certain limitations in terms biocompatibility, responsiveness to the wound environment, efficacy promoting tissue regeneration. To address these shortcomings, bioinspired hydration lubrication mechanism articular cartilage, we successfully designed developed an injectable situ photo-cross-linkable hydrogel, which was synthesized via modifying aminated hyaluronic acid with polymer obtained free radical polymerization o-nitrobenzyl alcohol derivative (NB) 2-methoxyethyl phosphocholine (MPC). The hydrophilic layer formed around zwitterionic charges MPC endowed hydrogel enhanced antimicrobial effects, whereas hydroxymethyl group NB enabled ultraviolet light-induced cross-linking property. doped polydopamine nanoparticles, facilitated multifaceted photothermally responsive antibacterial, anti-inflammation, angiogenesis. Specifically, upon injection precursor solution into site exposure light, cross-linked adhered closely skin tissues, achieving hemostasis exudate absorption. Additionally, showed excellent reactive oxygen species scavenging property, reducing cellular stress meanwhile bactericidal effect near-infrared light irradiation. Furthermore, its networked porous structure, conducive cell adhesion proliferation, remarkably enhancing activity wound-healing performances were investigated both vitro vivo experiments, showcasing potential for treatment applications, offering promising improvement over current methods providing photothermal responsive, biocompatible, effective process.

Language: Английский