Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(27), P. 5933 - 5948
Published: May 23, 2024
Language: Английский
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 165, P. 117152 - 117152
Published: June 20, 2023
Language: Английский
Citations
78
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150612 - 150612
Published: March 21, 2024
Language: Английский
Citations
59
ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095
Published: May 2, 2024
Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.
Language: Английский
Citations
53
BMEMat, Journal Year: 2023, Volume and Issue: unknown
Published: Sept. 19, 2023
Abstract Nanozymes have emerged as a promising alternative to natural enzymes, effectively addressing enzymes' inherent limitation. Versatility and potential applications of nanozyme span across various fields, with catalytic tumor therapy being one prominent area. This has sparked significant interest exploration in the utilization nanozymes for targeted cancer treatment. Recent advancements interdisciplinary research, nanotechnology, biotechnology, technology led emergence multi‐metallic‐based nanozymes, which exhibit tremendous further development. review focuses on investigating synergistic effects aiming enhance our understanding their activities facilitate broader applications. We comprehensively survey remarkable achievements synthesis, mechanisms, latest therapy. Furthermore, we identify current limitations prospects development new materials application novel technologies, along challenges associated underscores significance emphasizes need continued well impact realization breakthroughs
Language: Английский
Citations
48
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)
Published: March 29, 2024
Abstract Carbon‐based nanozymes have received considerable attention due to their superior biosafety, enhanced tolerance extreme conditions, and ease of chemical modification. However, limited material diversity unconfirmed molecular structure, carbon‐based face challenges such as relatively low enzyme activity unclear catalytic mechanisms. The development materials with well‐defined structures controllable properties is crucial for promoting the rapid progress nanozymes. Herein, 3,4,9,10‐perylenetetracarboxylic dianhydride (PD) exhibits both glucose oxidase (GOx)‐like catalase (CAT)‐like activities, which may be fact that PD possesses features highly conjugated structure high electron mobility. In addition, it demonstrated enzymatic related degree aggregation via characterization its morphology size. Based on excellent GOx‐like CAT‐like activities PD, a self‐cascade system constructed application in biofuel cells (BFCs). It worth mentioning BFC still maintains stability after working 30 days. Therefore, this study expands enzyme‐like systems discovers nanomaterials mobility can mimic enzymes. Additionally, multi‐enzyme are utilized construct systems, effectively improve performance BFCs.
Language: Английский
Citations
38
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 16011 - 16028
Published: March 26, 2024
Superbug infections and transmission have become major challenges in the contemporary medical field. The development of novel antibacterial strategies to efficiently treat bacterial conquer problem antimicrobial resistance (AMR) is extremely important. In this paper, a bimetallic CuCo-doped nitrogen–carbon nanozyme-functionalized hydrogel (CuCo/NC-HG) has been successfully constructed. It exhibits photoresponsive-enhanced enzymatic effects under near-infrared (NIR) irradiation (808 nm) with strong peroxidase (POD)-like oxidase (OXD)-like activities. Upon NIR irradiation, CuCo/NC-HG possesses photodynamic activity for producing singlet oxygen(1O2), it also high photothermal conversion effect, which not only facilitates elimination bacteria but improves efficiency reactive oxygen species (ROS) production accelerates consumption GSH. shows lower hemolytic rate better cytocompatibility than CuCo/NC positive charge macroporous skeleton restricting negatively charged range ROS destruction, strengthening efficiency. Comparatively, stronger bactericidal ability against methicillin-resistant Staphylococcus aureus (MRSA) ampicillin-resistant Escherichia coli (AmprE. coli) through destroying cell membranes negligible occurrence AMR. More importantly, plus can exhibit satisfactory performance absence H2O2, avoiding toxicity from high-concentration H2O2. vivo evaluation conducted using mouse wound infection model histological analyses, results show that upon suppress promote healing, without causing inflammation tissue adhesions.
Language: Английский
Citations
18
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Language: Английский
Citations
3
Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(24), P. 9237 - 9243
Published: May 26, 2023
Nanozymes have drawn much attention as an enzyme mimetic with low cost and stability in enhancing analytical performance. Herein, a peroxidase-mimicking nanozyme-improved enzyme-linked immunosorbent assay (ELISA) was developed employing the bimetallic PdRu nanozyme to replace natural enzymes catalytic carrier for sensing of Escherichia coli O157:H7 (E. O157:H7). The displayed ultrahigh activity, possessing rate that 5-fold higher than horseradish peroxidase (HRP). In addition, exhibited great biological affinity antibody (affinity constant about 6.75 × 1012 M) high stability. All those advantages ensure successful establishment construction novel colorimetric biosensor E. detection. PdRu-based ELISA not only achieved ultrasensitive detection sensitivity (8.7 102 CFU/mL) by approximately 288-fold compared traditional HRP-based also possessed satisfactory specificity reproducibility (relative standard deviation (RSD) < 10%). Furthermore, feasibility PdRu-ELISA further evaluated detecting actual samples recoveries, indicating its potential applications bioassays clinical diagnostics.
Language: Английский
Citations
36
Small, Journal Year: 2023, Volume and Issue: 20(21)
Published: Dec. 15, 2023
Abstract Keratitis, an inflammation of the cornea caused by bacterial or fungal infections, is one leading causes severe visual disability and blindness. Keratitis treatment requires both prevention infection reduction inflammation. However, owing to their limited therapeutic functions, in addition ocular barrier, existing conventional medications are characterized poor efficacy low bioavailability, requiring high dosages frequent topical treatment, which represents a burden on patients increases risk side effects. In this study, manganese oxide nanocluster‐decorated graphdiyne nanosheets (MnO x /GDY) developed as multienzyme‐like nanozymes for infectious keratitis loaded into hyaluronic acid polymethyl methacrylate‐based microneedles (MGMN). MGMN not only exhibits antimicrobial anti‐inflammatory effects its activities, including oxidase, peroxidase, catalase, superoxide dismutase mimics but also crosses barrier shows increased bioavailability via microneedle system. Moreover, demonstrated eliminate pathogens, prevent biofilm formation, reduce inflammation, alleviate hypoxia, promote repair corneal epithelial damage vitro, ex vivo, vivo experiments, thus providing better effect than commercial ophthalmic voriconazole, with no obvious microbial resistance cytotoxicity.
Language: Английский
Citations
33
ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(10), P. 2807 - 2819
Published: Sept. 14, 2023
Acute kidney injury (AKI) is a severe renal dysfunction syndrome associated with high morbidity and mortality. Excessive production of reactive oxygen/nitrogen species (RONS) involved in the development progression AKI. Therefore, scavenging endogenous RONS reducing excessive oxidative stress essential for restoring function after Although nanozyme-mediated antioxidant therapy has been proposed as an effective strategy to prevent AKI, low uptake organ toxicity hinder its potential practical applications. To address this problem, we have designed metal-phenolic nanozyme named RosA-Mn NPs, which possesses cascade functionalities. The multienzymatic capacity well broad spectrum ROS free radical activities. As expected, NPs promote recovery mitochondrial reduce endoplasmic reticulum secondary inflammation through vitro. Moreover, overcome shortcomings artificial enzymes that failed rapidly accumulate tissues. tubular targeting could be exploited mitigate damage, improve functions, eventually Notably, also protect from oxidation cisplatin-induced AKI mouse model. RNA sequencing analysis demonstrated autophagy, apoptosis, antioxidation-related pathways were modulated by treatment NPs. In summary, activities biocompatibility show great other ROS-related diseases.
Language: Английский
Citations
28