International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 285, P. 138345 - 138345
Published: Dec. 3, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 285, P. 138345 - 138345
Published: Dec. 3, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132391 - 132391
Published: May 17, 2024
Language: Английский
Citations
50Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 333, P. 122003 - 122003
Published: Feb. 27, 2024
Language: Английский
Citations
28International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131171 - 131171
Published: April 2, 2024
Language: Английский
Citations
7International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 298, P. 139886 - 139886
Published: Jan. 14, 2025
Language: Английский
Citations
0Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 356, P. 123381 - 123381
Published: Feb. 14, 2025
Language: Английский
Citations
0International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141059 - 141059
Published: Feb. 15, 2025
Language: Английский
Citations
0Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100801 - 100801
Published: April 1, 2025
Language: Английский
Citations
0Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Hyperuricemia (HUA) is a prevalent metabolic disorder associated with chronic disease, posing significant global health challenges. Coix seed, traditional cereal, has shown therapeutic potential against HUA, oligosaccharides serving as its primary active components. However, the mechanisms of seed in HUA management remain underexplored. In this study, novel oligosaccharide was isolated from (CSO) through enzymatic hydrolysis and column chromatography. Structural analysis revealed that CSO primarily composed glucose, backbone →4)-β-Glcp-(1→ linkages. exhibited hypouricemic effects both adenosine-induced HK-2 cells mice by inhibiting XOD activity regulating urate transporter expression. Furthermore, restored lipid imbalances, particularly PS PC, modulated gut microbiota increasing Ruminococcus, Akkermansia, Lachnospiraceae abundance to alleviate HUA-related systemic disturbances. Importantly, alleviated HUA-induced renal injury downregulating IL-6/JAK2/STAT3 signaling pathway. This study provided meaningful evidence supporting effect on offered new directions for natural interventions health.
Language: Английский
Citations
0International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136641 - 136641
Published: Oct. 18, 2024
Language: Английский
Citations
3International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135256 - 135256
Published: Sept. 2, 2024
Language: Английский
Citations
2