Isomerism of Cyclodextrin Tetramer Induced by Alkali Halide Cluster Ions Observed by Ion Mobility Spectrometry–Mass Spectrometry DOI
Jiyeon Lee,

Yunyoung Ahn,

Minsu Kim

et al.

Journal of the American Society for Mass Spectrometry, Journal Year: 2024, Volume and Issue: 35(3), P. 622 - 630

Published: Feb. 8, 2024

Cyclodextrins (CDs) exhibit versatile self-assembly properties due to their hydrophilic and hydrophobic components, with applications such as drug delivery selective binding. While research on CD is extensive, limited studies have explored aggregation behavior, particularly in interactions small ionic guests. The present work investigates the structure of β-CD tetramers aggregated alkali metal chloride clusters using ion mobility spectrometry–mass spectrometry (IMS-MS). results revealed that diverse structures emerge tetramer depending cluster size. Notably, doubly charged exhibits distinct trends specific numbers MCl for Na+ K+ ions. After initially adopting a bucket-wheel two internal cations, transforms into new isomer tetrahedral configuration upon addition. formation closely linked filling cavity volume interactions, which possibly compensate weakened hydrogen bonds between CDs. Theoretical calculations further support structures, showing well-matched collision cross-section (CCS) values compared experimental CCS values. This study highlights role potential templates, leading novel assemblies.

Language: Английский

Injectable hyaluronic acid–cyclodextrin-based hydrogels for localized and sustained release of anticancer drugs DOI
Dinh Trung Nguyen, Le Hang Dang,

Hai Khoa Le

et al.

Macromolecular Research, Journal Year: 2024, Volume and Issue: 32(8), P. 777 - 788

Published: June 17, 2024

Language: Английский

Citations

4
Intercalation of GO-Ag nanoparticles in cellulose acetate nanofiltration mixed matrix membrane for efficient removal of chromium and cobalt ions from wastewater DOI
Muhammad Hamad Zeeshan,

Umm E. Ruman,

Muhammad Imtiaz Shafiq

et al.

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(5), P. 113713 - 113713

Published: July 30, 2024

Language: Английский

Citations

4
Β-Cyclodextrin-based materials for 3D printing, cancer therapy, tissue engineering, and wound healing DOI
Malairaj Sathuvan, Sunhong Min, Karthikeyan Narayanan

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157272 - 157272

Published: Oct. 1, 2024

Language: Английский

Citations

4
Two-Dimensional Organic–Inorganic van der Waals Hybrids DOI

Fucai Cui,

Víctor García‐López, Zhiyong Wang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Two-dimensional organic-inorganic (2DOI) van der Waals hybrids (vdWhs) have emerged as a groundbreaking subclass of layer-stacked (opto-)electronic materials. The development 2DOI-vdWhs via systematically integrating inorganic 2D layers with organic crystals at the molecular/atomic scale extends capabilities traditional vdWhs, thanks to their high synthetic flexibility and structural tunability. Constructing an hybrid interface atomic precision will unlock new opportunities for generating unique interfacial transport properties by combining strengths layers, thus allowing us satisfy growing demand multifunctional applications. Here, this review provides comprehensive overview latest advancements in chemical synthesis, characterization, numerous applications 2DOI-vdWhs. Firstly, we introduce chemistry physical recently rising (O2DCs), which feature crystalline nanostructures comprising carbon-rich repeated units linked covalent/noncovalent bonds exhibit strong in-plane extended π-conjugation weak interlayer vdWs interaction. Simultaneously, representative (I2DCs) are briefly summarized. After that, strategies be summarized, including synthesizing single-component O2DCs dimensional control vdWhs I2DCs. With these approaches, dimension, stacking modes, composition highlighted. Subsequently, special focus given on discussion optical electronic materials closely relevant structures, so that can establish general structure-property relationship In addition properties, devices such transistors, photodetectors, sensors, spintronics, neuromorphic well energy discussed. Finally, provide outlook discuss key challenges future development. This aims foundational understanding inspire further innovation next-generation transformative technological potential.

Language: Английский

Citations

4
Improved Biomineralization Using Cellulose Acetate/Magnetic Nanoparticles Composite Membranes DOI Open Access
Mădălina Oprea, Andreea Mădălina Pandele, Aurelia Cristina Nechifor

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 209 - 209

Published: Jan. 15, 2025

Following implantation, infections, inflammatory reactions, corrosion, mismatches in the elastic modulus, stress shielding and excessive wear are most frequent reasons for orthopedic implant failure. Natural polymer-based coatings showed especially good results achieving better cell attachment, growth tissue-implant integration, it was found that inclusions of nanosized fillers coating structure improves biomineralization consequently osseointegration, as nanoparticles represent calcium phosphate nucleation centers lead to deposition highly organized hydroxyapatite crystallites on surface. In this study, magnetic synthesized by co-precipitation method were used preparation cellulose acetate composite through phase-inversion method. The ability membranes tested Taguchi method, nanostructured formed at surface membrane (with a higher organization degree purity, Ca/P percentage closer one seen with stoichiometric hydroxyapatite, compared deposited neat acetate). obtained indicate potential new application field orthopedics.

Language: Английский

Citations

0
β-Cyclodextrin-derived alternating poly(glyco-triazole)s behave as amylose mimics DOI
Adriana A. Kolender, Matthieu Pélingre,

Cristel Yacovone

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113948 - 113948

Published: April 1, 2025

Language: Английский

Citations

0
Enhanced solubility and biological activities of Flufenamic acid through β-Cyclodextrin derivatives inclusion complexes: A comprehensive study DOI
Sonaimuthu Mohandoss,

Kuppu Sakthi Velu,

Rizwan Wahab

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 402, P. 124765 - 124765

Published: April 16, 2024

Language: Английский

Citations

3
Curcumin-loaded γ -cyclodextrin-grafted hyaluronic acid nanoassimblies: In vitro investigation of anti-proliferative, wound healing, and anti-inflammatory potential DOI
Fedaa Adaileh, Walhan Alshaer, Hamdi Nsairat

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 87, P. 104886 - 104886

Published: Aug. 26, 2023

Language: Английский

Citations

8
Non-Viral Systems Based on PAMAM-Calix-Dendrimers for Regulatory siRNA Delivery into Cancer Cells DOI Open Access
Pavel Padnya, Igor Shiabiev,

Dmitry Pysin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12614 - 12614

Published: Nov. 24, 2024

Cancer is one of the most common diseases in developed countries. Recently, gene therapy has emerged as a promising approach to cancer treatment and already entered clinical practice worldwide. RNA interference-based method for treatment. However, there are number limitations that require vectors deliver therapeutic nucleic acids target tissues organs. Active research currently underway find highly effective, low-toxic nanomaterials capable acting nanocarriers. In this study, we demonstrated first time ability symmetrical polyamidoamine dendronized thiacalix[4]arenes (PAMAM-calix-dendrimers) form stable positively charged complexes with siRNAs, protect them from enzymatic degradation, efficiently material HeLa cells. A distinctive feature PAMAM-calix-dendrimers was unusual decrease hemo- cytotoxicity increasing generation, while these compounds did not cause toxic effects at concentrations required siRNA binding delivery. comparative analysis efficiency complex formation classical PAMAM dendrimers siRNAs also performed. The findings may facilitate creation novel unique delivery systems nanomedicine development.

Language: Английский

Citations

2
Recent Development of Supramolecular Cancer Theranostics Based on Cyclodextrins: A Review DOI Creative Commons

Wenting Hu,

Binglin Ye,

Guocan Yu

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(8), P. 3441 - 3441

Published: April 13, 2023

With the development of personalized medical demands for precise diagnosis, rational management and effective cancer treatment, supramolecular theranostic systems have received widespread attention due to their reversibly switchable structures, sensitive response biological stimuli integration ability multiple capabilities in a single platform with programmable fashion. Cyclodextrins (CDs), benefiting from excellent characteristics, such as non-toxicity, easy modification, unique host–guest properties, good biocompatibility, etc., building blocks, serve an all-purpose strategy fabrication theranostics nanodevice that is capable biosafety, controllability, functionality programmability. This review focuses on CD-bioimaging probes, CD-drugs, CD-genes, CD-proteins, CD-photosensitizers CD-photothermal agents well multicomponent cooperation regards functions diagnosis (or) therapeutics treatment. By introducing several state-of-the-art examples, emphasis will be placed design various functional modules, interaction strategies under fantastic topological structures hidden “bridge” between therapeutic efficacy, aiming further comprehension important role cyclodextrin-based nanoplatform advancing theranostics.

Language: Английский

Citations

5