Nanoparticle-Based Delivery Systems for Vaccines

Vaccines, Journal Year: 2022, Volume and Issue: 10(11), P. 1946 - 1946

Published: Nov. 17, 2022

Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional vaccinations may have low immunogenicity and, in situations, only provide partial protection. A new class of nanoparticle-based has shown considerable promise addressing majority shortcomings traditional and subunit vaccines. This due recent breakthroughs chemical biological engineering, which allow for exact regulation nanoparticle size, shape, functionality, surface characteristics, resulting improved antigen presentation robust immunogenicity. blend physicochemical, immunological, toxicological experiments can be used accurately characterize nanovaccines. narrative review will an overview current scenario nanovaccine.

Language: Английский

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Natural polymers in bio-degradable/edible film: A review on environmental concerns, cold plasma technology and nanotechnology application on food packaging- A recent trends

Food Chemistry Advances, Journal Year: 2022, Volume and Issue: 1, P. 100135 - 100135

Published: Oct. 1, 2022

Global food waste is the biggest issue owing to spoilage. According world program, approx. 35 million people worldwide suffer from acute malnutrition. Despite this, modern civilization has a significant problem with pollution spurred by synthetic plastics (SPs). So, natural polymers are essential in reducing spoilage and this planet. Therefore, biodegradable/edible films coatings have drawn much attention. This review paper primarily emphasizes addresses historical perspective, various types of (NPs) their application packaging industries, environmental concerns, cold plasma technology nanotechnology prospects biodegradable employed production edible packaging. In study, polysaccharides proteins that been considered. Currently, materials gaining popularity these days because pollutants produced improper disposal plastic packaging, usage increased. However, advantageous properties for development they biodegradable, biocompatible, minimal toxicity properties. such as induced modify film mechanical, physical, chemical, barrier. Consequently, may be combined produce wide range composite excellent mechanical biological properties, making them suitable

Language: Английский

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A comprehensive review on Moringa oleifera nanoparticles: importance of polyphenols in nanoparticle synthesis, nanoparticle efficacy and their applications

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 19, 2024

Abstract Moringa oleifera is one of the popular functional foods that has been tremendously exploited for synthesis a vast majority metal nanoparticles (NPs). The diverse secondary metabolites present in this plant turn it into green tool different NPs with various biological activities. In review, we discussed types including silver, gold, titanium oxide, iron and zinc oxide produced from extract parts M. oleifera. Different take role as reducing, stabilizing, capping agent, depending on source extract, color solution changes within NP synthesis. We highlighted polyphenols among major constituents extract. methods could lead to formation sizes shapes play crucial biomedical application were critically discussed. further debated mechanism interaction cells, their clearance body. made anticancer, antimicrobial, wound healing, water treatment agent also Small show better antimicrobial activity, while they can be easily cleared body through kidney. contrast, large are taken by mono nuclear phagocyte system (MPS) cells. case shape, spherical shape penetrate bacteria, stronger antibacterial activity compared other shapes. Finally, review aims correlate key characteristics such size interactions cells designing engineering them bio-applications especially therapeutic purposes. Graphical

Language: Английский

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Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(26)

Published: Aug. 4, 2023

Abstract The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, have found significant role improving drug delivery inhibiting the growth metastasis tumor cells. Moreover, recent studies highlighted potential modulating microenvironment (TME) enhancing activity immune cells improve therapy efficacy. Various types are currently utilized carriers, immunosuppressants, activators, immunoassay reagents, more for immunotherapy. Necessarily, used immunotherapy can be grouped into two categories: organic inorganic nanomaterials. Though both shown ability achieve purpose immunotherapy, composition properties result differences mechanisms modes action. Organic further divided polymers, cell membranes, nanoemulsion‐modified, hydrogel forms. At same time, broadly classified nonmetallic metallic current work aims explore action these different prospects promoting

Language: Английский

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An Overview of Essential Microelements and Common Metallic Nanoparticles and Their Effects on Male Fertility

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(17), P. 11066 - 11066

Published: Sept. 4, 2022

Numerous factors affect reproduction, including stress, diet, obesity, the use of stimulants, or exposure to toxins, along with heavy elements (lead, silver, cadmium, uranium, vanadium, mercury, arsenic). Metals, like other xenotoxins, can cause infertility through, e.g., impairment endocrine function and gametogenesis excess production reactive oxygen species (ROS). The advancement nanotechnology has created another hazard human safety through metals in form nanomaterials (NMs). Nanoparticles (NPs) exhibit a specific ability penetrate cell membranes biological barriers body. These ultra-fine particles (<100 nm) enter body respiratory tract, food, skin, injection, implantation. Once absorbed, NPs are transported various organs blood lymph. Absorbed NPs, thanks ultrahigh reactivity compared bulk materials microscale size, disrupt homeostasis as result interaction molecules such DNA, lipids, proteins; interfering functioning cells, organs, physiological systems; leading severe pathological dysfunctions. Over past decades, much research been performed on reproductive effects essential trace elements. hypothesis that disturbances metabolism one many causes unquestionably confirmed. This review examines complex risks for men regarding potentially harmless xenobiotics based series 298 articles over 30 years. was conducted using PubMed, Web Science, Scopus databases searching papers devoted vivo vitro studies related influence (iron, selenium, manganese, cobalt, zinc, copper, molybdenum) widely used metallic male reproduction potential.

Language: Английский

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Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats

Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2133 - 2133

Published: Oct. 28, 2022

This study examined the effects of exposure to lead acetate (PbAc) and/or aluminum trioxide nanoparticles (Al2O3NPs) on testicular function. Additionally, probable reproprotective quercetin (QTN) against Al2O3NPs and PbAc co-exposure in male Sprague Dawely rats were assessed. (100 mg/kg b.wt.), (50 QTN (20 b.wt.) orally administered for 60 days. Then, spermiogram, histopathological examinations testis accessory glands, immunohistochemical detection androgen receptors (AR) tumor necrotic factor alpha (TNF-α) achieved. Moreover, serum levels sex hormones antioxidant indices estimated. The results showed that caused significant sperm abnormalities, oxidative stress, changes. Furthermore, testosterone, LH, FSH significantly decreased, while estradiol increased. co-exposed group had more obvious disturbances. co-administration reversed PbAc-induced alterations, reduced defenses, altered AR TNF-α immune expression tissues. Conclusively, evoked dysfunction by inducing injury inflammation. However, oral dosing effectively mitigated negative suppressing stress inflammation improving defense system.

Language: Английский

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Toxicity and Molecular Mechanisms of Actions of Silver Nanoparticles

Journal of Biomaterials and Nanobiotechnology, Journal Year: 2023, Volume and Issue: 14(03), P. 53 - 70

Published: Jan. 1, 2023

Silver nanoparticles (AgNPs) have gained popularity due to their antibacterial properties, and are therefore widely used in several applications such as wound dressings, food packaging, water purification. However, the toxicity of AgNPs humans environment is a growing concern. This review aims summarize current knowledge on molecular mechanisms action AgNPs. The can be attributed small size, which allows them enter cells interact with cellular components. Reports suggest that induce cell death, DNA damage, oxidative stress various types. toxic effects differ based shape, surface charge, coating. behind involve production reactive oxygen species, disruption membranes, activation proinflammatory cytokines. Overall, dependent factors, more research needed fully understand toxicity. highlights need for proper risk assessments regulations minimize adverse human health environment.

Language: Английский

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Characterization and Synthesis of Nanomaterial for Vaccine Delivery

Published: Jan. 1, 2025

Language: Английский

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Personalized Nanomedicine-Mediated immune regulation for Anti-Rejection in organ transplantation

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125450 - 125450

Published: March 1, 2025

Language: Английский

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Effects of superparamagnetic iron oxide nanoparticles (SPIONS) testicular injection on Leydig cell function and sperm production in a murine model

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 126, P. 108584 - 108584

Published: March 30, 2024

Language: Английский

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