Phytochemical Analysis,
Journal Year:
2024,
Volume and Issue:
35(5), P. 1152 - 1173
Published: April 9, 2024
Abstract
Introduction
Artemisia
absinthium
L.
is
a
well‐known
medicinal,
aromatic,
and
edible
plant
with
important
medicinal
economic
properties
long
history
of
use
in
treating
liver
inflammation
other
diseases;
however,
there
has
been
insufficient
progress
quality
control.
Objective
This
study
aimed
to
investigate
the
markers
for
anti‐inflammatory
antioxidant
activities
A.
based
on
spectrum–effect
relationship
analysis.
Materials
methods
Eighteen
batches
from
different
origins
were
used.
Chemical
fingerprints
obtained
by
ultra‐performance
liquid
chromatography
(UPLC).
The
chemical
compositions
identified
quadrupole‐Orbitrap
high‐resolution
mass
spectrometry.
Anti‐inflammatory
activity
was
assessed
inhibition
cyclooxygenase‐2
15‐lipoxygenase
vitro
nitric
oxide
release
lipopolysaccharide‐induced
BV‐2
cells.
Antioxidant
DPPH
ABTS
radical
scavenging
assays.
between
bioactivity
then
analyzed
using
chemometrics
including
gray
relational
analysis,
bivariate
correlation
orthogonal
partial
least
squares
Results
Different
extracts
possessed
significant
varying
degrees.
Eighty
compounds
,
12
main
common
peaks
UPLC
fingerprints.
P3
(chlorogenic
acid),
P5
(isochlorogenic
acid
A),
P6
C)
screened
as
most
promising
active
analysis
further
validated
their
remarkable
effects.
Conclusion
first
screen
establishing
relationship,
which
can
provide
reference
development
standards
research
.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(7), P. 924 - 924
Published: March 23, 2024
Chlorogenic
acid
(CGA)
is
a
type
of
polyphenol
compound
found
in
rich
concentrations
many
plants
such
as
green
coffee
beans.
As
an
active
natural
substance,
CGA
exerts
diverse
therapeutic
effects
response
to
variety
pathological
challenges,
particularly
conditions
associated
with
chronic
metabolic
diseases
and
age-related
disorders.
It
shows
multidimensional
functions,
including
neuroprotection
for
neurodegenerative
disorders
diabetic
peripheral
neuropathy,
anti-inflammation,
anti-oxidation,
anti-pathogens,
mitigation
cardiovascular
disorders,
skin
diseases,
diabetes
mellitus,
liver
kidney
injuries,
anti-tumor
activities.
Mechanistically,
its
integrative
functions
act
through
the
modulation
anti-inflammation/oxidation
homeostasis.
can
thwart
inflammatory
constituents
at
multiple
levels
curtailing
NF-kB
pathways
neutralize
primitive
factors,
hindering
propagation,
alleviating
inflammation-related
tissue
injury.
concurrently
raises
pivotal
antioxidants
by
activating
Nrf2
pathway,
thus
scavenging
excessive
cellular
free
radicals.
elevates
AMPK
maintenance
restoration
homeostasis
glucose
lipids.
Additionally,
neuromodulation
targeting
neuroreceptors
ion
channels.
In
this
review,
we
systematically
recapitulate
CGA’s
pharmacological
activities,
medicinal
properties,
mechanistic
actions
potential
agent.
Further
studies
defining
specific
molecules,
improving
bioavailability,
validating
clinical
efficacy
are
required
corroborate
CGA.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
38(1), P. 280 - 304
Published: Oct. 23, 2023
Abstract
This
review
focuses
on
the
potential
ameliorative
effects
of
polyphenolic
compounds
derived
from
human
diet
hepatic
diseases.
It
discusses
molecular
mechanisms
and
recent
advancements
in
clinical
applications.
Edible
polyphenols
have
been
found
to
play
a
therapeutic
role,
particularly
liver
injury,
fibrosis,
NAFLD/NASH,
HCC.
In
regulation
exhibit
anti‐inflammatory
antioxidant
effects,
primarily
targeting
TGF‐β,
NF‐κB/TLR4,
PI3K/AKT,
Nrf2/HO‐1
signaling
pathways.
effectively
reverse
fibrotic
process
by
inhibiting
activation
stellate
cells
(HSC).
Furthermore,
show
efficacy
against
NAFLD/NASH
lipid
oxidation
accumulation,
mediated
through
AMPK,
SIRT,
PPARγ
Moreover,
several
anti‐HCC
activity
suppressing
tumor
cell
proliferation
metastasis.
inhibition
involves
blocking
Akt
Wnt
signaling,
as
well
epithelial‐mesenchymal
transition
(EMT).
Additionally,
trials
nutritional
evidence
support
notion
that
certain
can
improve
disease
associated
metabolic
disorders.
However,
further
fundamental
research
are
warranted
validate
dietary
polyphenols.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(6), P. 346 - 346
Published: June 20, 2024
Chlorogenic
acid
(CGA)
is
a
natural
polyphenol
found
in
coffee,
tea,
vegetables,
and
fruits.
It
exhibits
strong
antioxidant
activity
possesses
several
other
biological
properties,
including
anti-inflammatory
effects,
antimicrobial
activity,
insulin-sensitizing
properties.
Moreover,
it
may
improve
lipid
glucose
metabolism.
This
review
summarizes
the
available
information
on
therapeutic
effect
of
CGA
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD).
As
literature
search
engine,
browsers
PubMed,
Scopus,
Web
Science
databases,
ClinicalTrials.gov
register
were
used.
Animal
trials
clinical
studies
suggest
that
has
promising
potential
treating
MASLD
hepatic
steatosis.
Its
mechanisms
action
include
antioxidant,
anti-inflammatory,
anti-apoptotic
effects
via
activation
Nrf2
signaling
pathway
inhibition
TLR4/NF-κB
cascade.
Furthermore,
alleviation
by
also
involves
important
molecules
such
as
AMPK
physiological
processes
intestinal
barrier
gut
microbiota.
Nevertheless,
specific
target
cell
key
molecule
to
which
directed
remain
unidentified
require
further
study.
