Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 8, 2024
Degenerative
bone
and
joint
diseases
(DBJDs),
characterized
by
osteoporosis,
osteoarthritis,
chronic
inflammation
of
surrounding
soft
tissues,
are
systemic
conditions
primarily
affecting
the
skeletal
system.
Ferroptosis,
a
programmed
cell
death
pathway
distinct
from
apoptosis,
autophagy,
necroptosis.
Accumulating
evidence
suggests
that
ferroptosis
is
intricately
linked
to
pathogenesis
DBJDs,
targeting
its
regulation
could
be
beneficial
in
managing
these
conditions.
Natural
products,
known
for
their
anti-inflammatory
antioxidant
properties,
have
shown
unique
advantages
preventing
potentially
through
modulating
ferroptosis.
This
article
provides
an
overview
latest
research
on
ferroptosis,
with
focus
role
DBJDs
therapeutic
potential
natural
products
this
pathway,
offering
novel
insights
prevention
treatment
DBJDs.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8212 - 8212
Published: July 27, 2024
Ferroptosis
is
a
form
of
iron-dependent
regulated
cell
death
caused
by
the
accumulation
lipid
peroxides.
In
this
review,
we
summarize
research
on
impact
ferroptosis
disease
models
and
isolated
cells
in
various
types
arthritis.
While
most
studies
have
focused
rheumatoid
arthritis
(RA)
osteoarthritis
(OA),
there
limited
spondylarthritis
crystal
arthropathies.
The
effects
inducing
or
inhibiting
strongly
depend
studied
type.
search
for
new
therapeutic
targets,
chondrocytes
might
promising
any
type
On
other
hand,
induction
may
also
lead
to
desired
decrease
synovial
fibroblasts
RA.
Thus,
must
consider
cell-type-specific
Further
investigation
needed
clarify
these
complexities.
Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 11, 2024
Ferroptosis,
an
iron-ion-dependent
process
of
lipid
peroxidation,
damages
the
plasma
membrane,
leading
to
non-programmed
cell
death.
Osteoarthritis
(OA),
a
prevalent
chronic
degenerative
joint
disease
among
middle-aged
and
older
adults,
is
characterized
by
chondrocyte
damage
or
loss.
Emerging
evidence
indicates
that
ferroptosis
plays
role
in
OA
development.
However,
most
research
has
concentrated
on
regulation
involving
typical
iron
ions,
potentially
neglecting
significance
elevated
copper
ions
both
serum
fluid
patients
with
OA.
This
review
aims
fill
this
gap
systematically
examining
interplay
between
metabolism,
oxidative
stress,
ferroptosis,
copper-associated
death
It
will
provide
comprehensive
overview
ions'
regulating
their
dual
approach
seeks
offer
new
insights
for
further
research,
prevention,
treatment
