Theranostics,
Journal Year:
2020,
Volume and Issue:
11(3), P. 1016 - 1030
Published: Nov. 6, 2020
Macrophages
phagocytize
pathogens
to
initiate
innate
immunity
and
products
from
the
tumor
microenvironment
(TME)
mediate
immunity.
The
loss
of
tumor-associated
macrophage
(TAM)-mediated
immune
responses
results
in
suppression.
To
reverse
this
disorder,
regulatory
mechanism
TAMs
TME
needs
be
clarified.
Immune
molecules
(cytokines
chemokines)
have
been
widely
accepted
as
mutual
mediators
signal
transduction
past
few
decades.
Recently,
researchers
tried
seek
intrinsic
TAM
phenotypic
functional
changes
through
metabolic
connections.
Numerous
metabolites
derived
identified
that
induce
cell-cell
crosstalk
with
TAMs.
bulk
cells,
stromal
cells
produce
are
involved
regulation
Meanwhile,
some
regulate
biological
functions
well.
Here,
we
review
recent
reports
demonstrating
between
Cancer Discovery,
Journal Year:
2021,
Volume and Issue:
11(4), P. 933 - 959
Published: April 1, 2021
Abstract
Strategies
to
therapeutically
target
the
tumor
microenvironment
(TME)
have
emerged
as
a
promising
approach
for
cancer
treatment
in
recent
years
due
critical
roles
of
TME
regulating
progression
and
modulating
response
standard-of-care
therapies.
Here,
we
summarize
current
knowledge
regarding
most
advanced
TME-directed
therapies,
which
either
been
clinically
approved
or
are
currently
being
evaluated
trials,
including
immunotherapies,
antiangiogenic
drugs,
treatments
directed
against
cancer-associated
fibroblasts
extracellular
matrix.
We
also
discuss
some
challenges
associated
with
future
perspectives
this
evolving
field.
Significance:
This
review
provides
comprehensive
analysis
therapies
targeting
TME,
combining
discussion
underlying
basic
biology
clinical
evaluation
different
therapeutic
approaches,
highlighting
perspectives.
Frontiers in Immunology,
Journal Year:
2020,
Volume and Issue:
11
Published: May 15, 2020
The
success
of
cancer
immunotherapy
relies
on
the
knowledge
tumor
microenvironment
and
immune
evasion
mechanisms
in
which
tumor,
stroma
infiltrating
cells
function
a
complex
network.
potential
barriers
that
profoundly
challenge
overall
clinical
outcome
promising
therapies
need
to
be
fully
identified
counteracted.
Although
has
increasingly
been
applied,
we
are
far
from
understanding
how
utilize
different
strategies
best
way
combine
therapeutic
options
optimize
benefit.
This
review
intends
give
contemporary
detailed
overview
roles
cells,
exosomes
molecules
acting
they
relate
activation
escape.
Further,
current
novel
immunotherapeutic
will
discussed.
Frontiers in Immunology,
Journal Year:
2019,
Volume and Issue:
10
Published: Aug. 2, 2019
Cancer-associated
fibroblasts
(CAFs)
are
prominent
components
of
the
microenvironment
in
most
types
solid
tumors,
and
were
shown
to
facilitate
cancer
progression
by
supporting
tumor
cell
growth,
extracellular
matrix
remodeling,
promoting
angiogenesis,
mediating
tumor-promoting
inflammation.
In
addition
an
inflammatory
microenvironment,
tumors
characterized
immune
evasion
immunosuppressive
milieu.
recent
years,
CAFs
emerging
as
central
players
regulation
that
shapes
microenvironment.
contribute
escape
via
multiple
mechanisms,
including
secretion
cytokines
chemokines
reciprocal
interactions
mediate
recruitment
functional
differentiation
innate
adaptive
cells.
Moreover,
directly
abrogate
function
cytotoxic
lymphocytes,
thus
inhibiting
killing
this
review,
we
focus
on
advancements
our
understanding
how
drive
fate
tumor-infiltrating
cells
towards
provide
outlook
future
therapeutic
implications
may
lead
integration
preclinical
findings
into
design
novel
combination
strategies,
aimed
at
impairing
tumor-supportive
CAFs.
