Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

Immunity, Journal Year: 2024, Volume and Issue: 57(4), P. 876 - 889.e11

Published: March 12, 2024

Language: Английский

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Recent Advances and Clinical Potential of Near Infrared Photothermal Conversion Materials for Photothermal Hepatocellular Carcinoma Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(29)

Published: June 9, 2023

Abstract Growing concern about photothermal tumor therapy (PTT) as a promising alternative to conventional liver cancer treatment, which is treatment strategy that utilizes near‐infrared (NIR) light‐induced agents (PTAs) yield effects localize thermal damage for tumors. Herein, given the gap between experimental research and clinical application, this review seeks timely summarize highlight recent progress of PTAs used in vivo vitro last five‐year. The implications various on multifunctional conversion capability, structure‐performance correlations PTT, together with evaluation their potential application are systematically dissected further dig out what buried mechanism is. Besides, higher requirements put forward discrepancies crucial issues faced by different PTT related medical technical obstacles being conquered, lays solid theoretical foundation field oncology whole, especially cancer. Finally, it expected can present valuable guidance design efficient, photostability, biosafety‐aware anticancer while stepping into fast traffic lane from bench bedside foreseeable future.

Language: Английский

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Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: June 18, 2024

Abstract Tumorigenesis is a multistep process, with oncogenic mutations in normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic and expansion tissues, their transformation into cancer remains rare event, indicating presence of additional driver events for progression to an irreversible, highly heterogeneous, invasive lesion. Recently, researchers are emphasizing mechanisms environmental tumor risk factors epigenetic alterations that profoundly influencing early malignant evolution, independently inducing mutations. Additionally, evolution tumorigenesis reflects multifaceted interplay between cell-intrinsic identities various cell-extrinsic exert selective pressures either restrain uncontrolled proliferation or allow specific clones progress tumors. by which induce both intrinsic cellular competency remodel stress facilitate not fully understood. In this review, we summarize genetic, epigenetic, external events, effects on co-evolution transformed cells ecosystem during initiation evolution. A deeper understanding earliest molecular holds promise translational applications, predicting individuals at high-risk developing strategies intercept transformation.

Language: Английский

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Towards modulating the gut microbiota to enhance the efficacy of immune-checkpoint inhibitors

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(10), P. 697 - 715

Published: July 24, 2023

Language: Английский

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Injectable nano-composite hydrogels based on hyaluronic acid-chitosan derivatives for simultaneous photothermal-chemo therapy of cancer with anti-inflammatory capacity

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 310, P. 120721 - 120721

Published: Feb. 20, 2023

Language: Английский

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Role of the microbiota in response to and recovery from cancer therapy

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 24(5), P. 308 - 325

Published: Nov. 6, 2023

Language: Английский

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Cold and hot tumors: from molecular mechanisms to targeted therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 18, 2024

Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment therapy, only a minority patients exhibit positive response to it. In with solid tumors, those who respond well typically demonstrate an active profile referred as "hot" (immune-inflamed) phenotype. On other hand, non-responsive may distinct "cold" (immune-desert) phenotype, differing from features tumors. Additionally, there is more nuanced "excluded" positioned between and categories, known type. Effective differentiation understanding intrinsic factors, characteristics, TME, external factors are critical for predicting results. It widely accepted that therapy exerts profound effect on limited efficacy against or "altered" necessitating combinations therapeutic modalities enhance cell infiltration into tissue convert tumors ones. Therefore, aligning traits this review systematically delineates respective influencing extensively discusses varied approaches drug targets based assess efficacy.

Language: Английский

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Critical role of the gut microbiota in immune responses and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: May 14, 2024

The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there has been accumulating evidence connections between and cancer immunotherapy. Therefore, understanding functional regulating immune responses to immunotherapy is crucial for developing precision medicine. this review, we extract insights from state-of-the-art research decipher complicated crosstalk among microbiota, systemic system, context Additionally, as can account immune-related adverse events, discuss potential interventions minimize these effects clinical application five microbiota-targeted strategies that precisely increase efficacy Finally, holds promising target immunotherapeutics, summarize current challenges provide general outlook on future directions field.

Language: Английский

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In situ targeted base editing of bacteria in the mouse gut

Nature, Journal Year: 2024, Volume and Issue: 632(8026), P. 877 - 884

Published: July 10, 2024

Abstract Microbiome research is now demonstrating a growing number of bacterial strains and genes that affect our health 1 . Although CRISPR-derived tools have shown great success in editing disease-driving human cells 2 , we currently lack the to achieve comparable for targets situ. Here engineer phage-derived particle deliver base editor modify Escherichia coli colonizing mouse gut. Editing β-lactamase gene model E. strain resulted median efficiency 93% target population with single dose. Edited bacteria were stably maintained gut at least 42 days following treatment. This was achieved using non-replicative DNA vector, preventing maintenance dissemination payload. We then leveraged this approach edit several therapeutic relevance Klebsiella pneumoniae vitro demonstrate situ involved production curli pathogenic strain. Our work demonstrates feasibility modifying directly gut, offering new avenue investigate function opening door design microbiome-targeted therapies.

Language: Английский

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Multiplex protein imaging in tumour biology

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(3), P. 171 - 191

Published: Feb. 5, 2024

Language: Английский

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