Cancer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
ABSTRACT
Cancer‐associated
fibroblasts
(CAFs)
are
key
components
of
the
tumor
microenvironment
(TME).
Given
their
various
roles
in
progression
and
treatment
resistance,
CAFs
promising
therapeutic
targets
cancer.
The
elimination
tumor‐promoting
has
been
investigated
animal
models
to
determine
whether
it
effectively
suppresses
growth.
Based
on
recent
evidence,
several
simple
strategies
have
proposed
eliminate
attenuate
these
features.
In
addition,
attention
focused
critical
role
that
play
immunosuppressive
TME.
Therefore,
functional
reprogramming
combination
with
immune
checkpoint
inhibitors
also
as
a
possible
approach.
However,
although
potential
widely
characterized,
plasticity
heterogeneity
complicate
understanding
properties
present
difficulties
for
clinical
application.
Moreover,
identification
tumor‐suppressive
highlights
necessity
development
approaches
can
distinguish
switch
between
an
appropriate
manner.
this
review,
we
introduce
origins
diversity
CAFs,
cancer,
current
aimed
at
targeting
including
ongoing
evaluations.
Cancer Letters,
Journal Year:
2024,
Volume and Issue:
591, P. 216859 - 216859
Published: April 13, 2024
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
a
solid
organ
malignancy
with
high
mortality
rate.
Statistics
indicate
that
its
incidence
has
been
increasing
as
well
the
associated
deaths.
Most
patients
PDAC
show
poor
response
to
therapies
making
clinical
management
of
this
cancer
difficult.
Stromal
cells
in
tumor
microenvironment
(TME)
contribute
development
resistance
therapy
cells.
Cancer-associated
fibroblasts
(CAFs),
most
prevalent
stromal
TME,
promote
desmoplastic
response,
produce
extracellular
matrix
proteins
and
cytokines,
directly
influence
biological
behavior
These
multifaceted
effects
make
it
difficult
eradicate
from
body.
As
result,
CAF-targeting
synergistic
therapeutic
strategies
have
gained
attention
recent
years.
However,
due
substantial
heterogeneity
CAF
origin,
definition,
function,
plasticity,
majority
available
approaches
are
not
effective,
some
cases,
they
exacerbate
disease
progression.
This
review
primarily
elucidates
on
effect
CAFs
efficiency
various
treatment
modalities,
including
chemotherapy,
radiotherapy,
immunotherapy,
targeted
therapy.
Strategies
for
targeting
also
discussed.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 25, 2024
Abstract
Chronic
kidney
disease
(CKD)
is
a
public
health
problem
driven
by
myofibroblast
accumulation,
leading
to
interstitial
fibrosis.
Heterogeneity
recently
recognized
characteristic
in
fibroblasts
CKD,
but
the
role
of
different
populations
still
unclear.
Here,
we
characterize
proinflammatory
fibroblast
population
(named
CXCL-iFibro),
which
corresponds
an
early
state
differentiation
CKD.
We
demonstrate
that
CXCL-iFibro
co-localize
with
macrophages
and
participate
their
attraction,
switch
into
FOLR2+
from
CKD
stages
on.
In
vitro,
promote
ECM-secreting
myofibroblasts
through
WNT/β-catenin-dependent
pathway,
thereby
suggesting
reciprocal
crosstalk
between
these
macrophages.
Finally,
detection
at
predictive
poor
patient
prognosis,
shows
player
progression
demonstrates
clinical
relevance
our
findings.
Cancer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
ABSTRACT
Cancer‐associated
fibroblasts
(CAFs)
are
key
components
of
the
tumor
microenvironment
(TME).
Given
their
various
roles
in
progression
and
treatment
resistance,
CAFs
promising
therapeutic
targets
cancer.
The
elimination
tumor‐promoting
has
been
investigated
animal
models
to
determine
whether
it
effectively
suppresses
growth.
Based
on
recent
evidence,
several
simple
strategies
have
proposed
eliminate
attenuate
these
features.
In
addition,
attention
focused
critical
role
that
play
immunosuppressive
TME.
Therefore,
functional
reprogramming
combination
with
immune
checkpoint
inhibitors
also
as
a
possible
approach.
However,
although
potential
widely
characterized,
plasticity
heterogeneity
complicate
understanding
properties
present
difficulties
for
clinical
application.
Moreover,
identification
tumor‐suppressive
highlights
necessity
development
approaches
can
distinguish
switch
between
an
appropriate
manner.
this
review,
we
introduce
origins
diversity
CAFs,
cancer,
current
aimed
at
targeting
including
ongoing
evaluations.
