Natural killer cell therapies

Nature, Journal Year: 2024, Volume and Issue: 626(8000), P. 727 - 736

Published: Feb. 21, 2024

Language: Английский

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Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem

Theranostics, Journal Year: 2023, Volume and Issue: 13(5), P. 1607 - 1631

Published: Jan. 1, 2023

Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that generally regarded as genetic disease with diverse intertumor and intratumor heterogeneity. This perspective review mainly outlines the up-to-date knowledge ecology NPC progression, presents number conceptual stepping-stones. At beginning, I explicitly advocate nature (cancer) not but an ecological disease: multidimensional spatiotemporal "unity evolution" pathological ecosystem. The hallmarks proposed to act factors population fitness. Subsequently, cells are described invasive species its metastasis multidirectional dispersal. foundational principles include intraspecific relationship (e.g. communication) interspecific competition, predation, parasitism mutualism) interpreted understand progression. "Mulberry-fish-ponds" model can well illustrate dynamic reciprocity Tumor-host interface transition zone cancer, tumor buddings should be recognized islands separated from mainland. It noted tumor-host has significantly molecular functional edge effect because curvature irregularity. Selection driving therapy including hyperthermia for patients, future perspectives in such field "ecological pathology", "multidimensional tumoriecology" also discussed. advance "nothing evolution or makes sense except light other". tree constructed comprehensively point out research direction. Taken together, establishment theory might provide novel framework paradigm our understanding complex causal process potential preventive therapeutic applications patients.

Language: Английский

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Exploiting innate immunity for cancer immunotherapy

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Nov. 27, 2023

Abstract Immunotherapies have revolutionized the treatment paradigms of various types cancers. However, most these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune checkpoint blockade, or enhancing immunostimulatory bispecific T cell engager and chimeric antigen receptor (CAR)-T cell. Although agents already achieved great success, only a tiny percentage patients could benefit from immunotherapies. Actually, immunotherapy efficacy is determined multiple components in tumor microenvironment beyond immunity. Cells innate arm system, such as macrophages, dendritic cells, myeloid-derived suppressor neutrophils, natural killer unconventional also participate cancer evasion surveillance. Considering that cornerstone antitumor response, utilizing immunity provides potential therapeutic options for control. Up to now, exploiting agonists stimulator interferon genes, CAR-macrophage -natural therapies, metabolic regulators, novel exhibited potent activities preclinical clinical studies. Here, we summarize latest insights into roles cells discuss advances arm-targeted strategies.

Language: Английский

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The dynamic role of platelets in cancer progression and their therapeutic implications

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 24(1), P. 72 - 87

Published: Dec. 1, 2023

Language: Английский

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Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Dec. 2, 2023

Abstract The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provided immune system with signal to detect eliminate infected or cancerous cells. In context cancer, owing crucial immune-regulatory roles played by MHC-I molecules, abnormal modulation expression function could be hijacked tumor cells escape surveillance attack, thereby promoting tumoral progression impairing efficacy cancer immunotherapy. Here we reviewed discussed recent studies discoveries related their multidirectional functions in development mainly focusing interactions between multiple participators microenvironment highlighting significance targeting for optimizing immunotherapy a deeper understanding dynamic nature functioning mechanism cancer.

Language: Английский

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The hallmarks of cancer immune evasion

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(11), P. 1825 - 1863

Published: Oct. 10, 2024

Language: Английский

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New insights into the correlations between circulating tumor cells and target organ metastasis

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 21, 2023

Organ-specific metastasis is the primary cause of cancer patient death. The distant tumor cells to specific organs depends on both intrinsic characteristics and extrinsic factors in their microenvironment. During an intermediate stage metastasis, circulating (CTCs) are released into bloodstream from metastatic tumors. CTCs harboring aggressive or features can extravasate remote sites for continuous colonizing growth, leading further lesions. In past decade, numerous studies demonstrated that exhibited huge clinical value including predicting assessing prognosis monitoring treatment response et al. Furthermore, increasingly experiments dedicated identifying key molecules inside exploring how they mediate CTC-related organ-specific metastasis. Based above molecules, more inhibitors being developed target utilized completely clean CTCs, which should provide promising prospects administer advanced tumor. Recently, application various nanomaterials microfluidic technologies enrichment technology has assisted improve our deep insights phenotypic biological functions as a potential therapy target, may pave way us make practical strategies. present review, we mainly focus role involved targeted organ especially latest molecular mechanism research intervention strategies related CTCs.

Language: Английский

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The Function of NK Cells in Tumor Metastasis and NK Cell-Based Immunotherapy

Cancers, Journal Year: 2023, Volume and Issue: 15(8), P. 2323 - 2323

Published: April 16, 2023

Metastatic tumors cause the most deaths in cancer patients. Treating metastasis remains primary goal of current research. Although immune system prevents and kills tumor cells, function metastatic has been unappreciated for decades because are able to develop complex signaling pathways suppress responses, leading them escape detection elimination. Studies showed NK cell-based therapies have many advantages promise fighting cancers. We here review progression, specifically focusing on ability cells antimetastasis, how cell attack, as well recent development effective antimetastatic immunotherapies.

Language: Английский

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Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 2, 2024

Abstract Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-associated mortality. Despite its significance, mechanisms governing metastasis are not fully elucidated. Contemporary findings in domain biology have shed light on molecular aspects this intricate process. Tumor cells undergoing invasion engage with other cellular entities proteins en route their destination. Insights into these engagements enhanced our comprehension principles directing movement adaptability metastatic cells. The tumor microenvironment plays role facilitating proliferation by enabling navigate through stromal barriers. Such attributes influenced genetic epigenetic changes occurring surrounding milieu. A profound understanding process’s biological indispensable for devising efficacious therapeutic strategies. This review delves recent developments concerning metastasis-associated genes, important signaling pathways, microenvironment, metabolic processes, peripheral immunity, mechanical forces metastasis. In addition, we combine advances particular emphasis prospect developing effective interventions including most popular immunotherapies nanotechnology combat We also identified limitations current research metastasis, encompassing drug resistance, restricted animal models, inadequate biomarkers early detection methods, as well heterogeneity among others. It anticipated that comprehensive will significantly contribute advancement research.

Language: Английский

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Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept

Journal of Experimental & Clinical Cancer Research, Journal Year: 2024, Volume and Issue: 43(1)

Published: Jan. 2, 2024

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor immune microenvironment (TIME) formed by interactions among cancer cells, cancer-associated fibroblasts (CAF), and extracellular matrix (ECM) components drives PDAC in a more immunosuppressive direction: this major cause therapy resistance poor prognosis. In recent years, research has advanced our understanding signaling mechanism which TIME interact with evolution immunophenotyping. Through revolutionary technologies such as single-cell sequencing, we have gone from simply classifying PDACs “cold” “hot” to comprehensive approach immunophenotyping that considers all cells components. This key improving clinical efficacy treatments. review, elaborate on various PDAC, mechanisms underlying their interactions, latest into A deep these network will contribute effective combination TIME-based therapeutic approaches, checkpoint inhibitors (ICI), adoptive cell therapy, therapies targeting myeloid CAF reprogramming, stromal normalization. By selecting appropriate integrated based precise immunophenotyping, significant advances future treatment are possible.

Language: Английский

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