Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies DOI Creative Commons
Chang Zhu,

J Liao,

Yiyang Liu

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 14, 2024

Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout process liver formation, immune cells play pivotal role, particularly pre-metastatic and metastatic niches within liver. Immune establish extensive intricate interactions with tumor other components liver, collectively promoting sustaining growth metastases. Despite limited efficacy existing therapeutic modalities against some metastases, novel immune-based treatment approaches continuously being explored validated. Building on systematic elucidation immunosuppressive characteristics we potential immunotherapies applicable to patients from multiple dimensions.

Language: Английский

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions DOI Creative Commons

Peilin Lu,

Dongxue Ruan,

Meiqi Huang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

Citations

83
High-dimensional single-cell analysis of human natural killer cell heterogeneity DOI Creative Commons
Lucas Rebuffet, Janine Melsen,

Bertrand Escalière

et al.

Nature Immunology, Journal Year: 2024, Volume and Issue: 25(8), P. 1474 - 1488

Published: July 2, 2024

Abstract Natural killer (NK) cells are innate lymphoid (ILCs) contributing to immune responses microbes and tumors. Historically, their classification hinged on a limited array of surface protein markers. Here, we used single-cell RNA sequencing (scRNA-seq) cellular indexing transcriptomes epitopes by (CITE-seq) dissect the heterogeneity NK cells. We identified three prominent cell subsets in healthy human blood: NK1, NK2 NK3, further differentiated into six distinct subgroups. Our findings delineate molecular characteristics, key transcription factors, biological functions, metabolic traits cytokine each subgroup. These data also suggest two separate ontogenetic origins for cells, leading divergent transcriptional trajectories. Furthermore, analyzed distribution lung, tonsils intraepithelial lymphocytes isolated from individuals 22 tumor types. This standardized terminology aims at fostering clarity consistency future research, thereby improving cross-study comparisons.

Language: Английский

Citations

53
Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

Citations

12
Biometallic ions and derivatives: a new direction for cancer immunotherapy DOI Creative Commons
Lin Zhao,

Yajun Gui,

Jing Cai

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 15, 2025

Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become breakthrough treatment, achieving good efficacy wide range of cancers with its specificity and durability advantages. However, existing therapies still face challenges, such as tolerance escape. (e.g. zinc, copper, magnesium, manganese, etc.) can assist enhancing through activation cells, enhancement tumor antigen presentation, improvement microenvironment. addition, biometallic derivatives directly inhibit cell progression offer possibility effectively overcoming limitations current by promoting responses reducing immunosuppressive signals. This review explores potential application prospects immunotherapy, providing new ideas for future clinical metal part helping to guide development more effective safe therapeutic regimens.

Language: Английский

Citations

2
What is the role of microbial biotechnology and genetic engineering in medicine? DOI Creative Commons
Fernando Santos‐Beneit

MicrobiologyOpen, Journal Year: 2024, Volume and Issue: 13(2)

Published: March 31, 2024

Abstract Microbial products are essential for developing various therapeutic agents, including antibiotics, anticancer drugs, vaccines, and enzymes. Genetic engineering techniques, functional genomics, synthetic biology unlock previously uncharacterized natural products. This review highlights major advances in microbial biotechnology, focusing on gene‐based technologies medical applications.

Language: Английский

Citations

13
Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression DOI Creative Commons

Yunna Chen,

Qianqian Zhou,

Zongfang Jia

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3834 - 3854

Published: June 3, 2024

Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.

Language: Английский

Citations

13
Five decades of natural killer cell discovery DOI Creative Commons
Lewis L. Lanier

The Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 221(8)

Published: June 6, 2024

The first descriptions of “non-specific” killing tumor cells by lymphocytes were reported in 1973, and subsequently, the mediators activity named “natural killer” (NK) Rolf Kiessling colleagues at Karolinska Institute 1975. was detected mice, rats, humans that had no prior exposure to tumors, major histocompatibility complex (MHC) antigen matching effectors not required, responsible distinct from MHC-restricted, antigen-specific T cells. In ensuing five decades, research many labs has extended knowledge NK beyond an vitro curiosity demonstrate their vivo relevance host defense against tumors microbial pathogens role regulation immune system. This brief Perspective highlights a timeline few selected advancements cell biology personal perspective being involved this quest.

Language: Английский

Citations

12
In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy DOI
Lei Peng, Paul Renauer, Giacomo Sferruzza

et al.

Nature Biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: June 25, 2024

Language: Английский

Citations

11
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization DOI Creative Commons

Sumei Chen,

Haitao Zhu, Youssef Jounaïdi

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Nov. 8, 2024

Abstract Natural killer (NK) cells, initially identified for their rapid virus-infected and leukemia cell killing tumor destruction, are pivotal in immunity. They exhibit multifaceted roles cancer, viral infections, autoimmunity, pregnancy, wound healing, more. Derived from a common lymphoid progenitor, they lack CD3, B-cell, or T-cell receptors but wield high cytotoxicity via perforin granzymes. NK cells orchestrate immune responses, secreting inflammatory IFNγ immunosuppressive TGFβ IL-10. CD56 dim bright execute cytotoxicity, while also regulate However, beyond the dichotomy, detailed phenotypic diversity reveals many functional subsets that may not be optimal cancer immunotherapy. In this review, we provide comprehensive snapshots of cells’ functions states activation inhibitions angiogenesis, pregnancy fertility, aging, senescence mediated by complex signaling ligand-receptor interactions, including impact environment. As use engineered immunotherapy accelerates, often footsteps T-cell-derived engineering, examine interactions with other effectors relevant limitations microenvironment, intending to understand how enhance cytolytic activities specifically

Language: Английский

Citations

11
TGF-β signalling limits effector function capacity of NK cell anti-tumour immunity in human bladder cancer DOI Creative Commons

Joshua Wong,

Timothy R. McCulloch, Louisa Alim

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 104, P. 105176 - 105176

Published: May 28, 2024

Natural killer (NK) cells are important innate immunity players and have unique abilities to recognize eliminate cancer cells, particularly in settings of antibody-opsonization antibody-dependant cellular cytotoxicity (ADCC). However, NK cell-based responses bladder cancers therapeutic antibodies typically immunosuppressed, these immunosuppressive mechanisms largely unknown.

Language: Английский

Citations

9