Regulatory role of PPAR in colorectal cancer DOI Creative Commons
Cong Wang,

Tingcong Lv,

Binghui Jin

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 28, 2025

Language: Английский

Embracing cancer complexity: Hallmarks of systemic disease DOI Open Access
Charles Swanton, Elsa Bernard,

Chris Abbosh

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(7), P. 1589 - 1616

Published: March 1, 2024

Language: Английский

Citations

173
Tumor Abnormality-Oriented Nanomedicine Design DOI
Quan Zhou, Jiajia Xiang, Nasha Qiu

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 10920 - 10989

Published: Sept. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Language: Английский

Citations

85
Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications DOI Creative Commons
Dongdong Xu, Yang Li, Shouchun Yin

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(6), P. 3167 - 3204

Published: Jan. 1, 2024

We report strategies employed by metallacycle/metallacage-based supramolecular coordination complexes to enhance water solubility and biostability reduce potential toxicity side effects for biomedical applications.

Language: Английский

Citations

31
Why do patients with cancer die? DOI
Adrienne Boire, Katy Burke, Thomas R. Cox

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(8), P. 578 - 589

Published: June 19, 2024

Language: Английский

Citations

29
Targeting the tumour vasculature: from vessel destruction to promotion DOI
Sophie Guelfi, Kairbaan Hodivala‐Dilke, Gabriele Bergers

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(10), P. 655 - 675

Published: Aug. 29, 2024

Language: Английский

Citations

27
Crosstalk Between the Nervous System and Tumor Microenvironment: Functional Aspects and Potential Therapeutic Strategies DOI
Lei Wang, Jingjing Ge,

Huiqiong Han

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 594, P. 216986 - 216986

Published: May 24, 2024

Language: Английский

Citations

18
Next Directions in the Neuroscience of Cancers Arising outside the CNS DOI Open Access
Moran Amit, Corina Anastasaki, Robert Dantzer

et al.

Cancer Discovery, Journal Year: 2024, Volume and Issue: 14(4), P. 669 - 673

Published: April 4, 2024

Summary: The field of cancer neuroscience has begun to define the contributions nerves initiation and progression; here, we highlight future directions basic translational for malignancies arising outside central nervous system.

Language: Английский

Citations

17
Nociceptive neurons promote gastric tumour progression via a CGRP–RAMP1 axis DOI
Xiaofei Zhi, Feijing Wu,

Jin Qian

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

5
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment DOI Creative Commons

Qibo Huang,

Bai Hu,

Zhang Ping

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 17, 2025

The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected tumorigenesis. In particular, peripheral central nervous systems, synapse, neurotransmitters, neurotrophins affect progression metastasis through various regulatory approaches immune microenvironment. this review, we summarized tumorigenesis metastasis, which controlled by systems. We also explored roles neurotransmitters progression. Moreover, examined interplay system have identified drugs target treatment. review present work supporting agent targeting could potential to improve therapy.

Language: Английский

Citations

2
Perineural Invasion in Cervical Cancer DOI Creative Commons

Xiayi Li,

Xiaojing Yang,

Shuchen Lin

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217561 - 217561

Published: Feb. 1, 2025

Language: Английский

Citations

2