New insights into immune cells in cancer immunotherapy: from epigenetic modification, metabolic modulation to cell communication

MedComm, Journal Year: 2024, Volume and Issue: 5(6)

Published: May 23, 2024

Abstract Cancer is one of the leading causes death worldwide, and more effective ways attacking cancer are being sought. immunotherapy a new therapeutic method after surgery, radiotherapy, chemotherapy, targeted therapy. aims to kill tumor cells by stimulating or rebuilding body's immune system, with specific efficiency high safety. However, only few patients respond due complex variable characters escape, behavior regulatory mechanisms need be deeply explored from dimensions. Epigenetic modifications, metabolic modulation, cell‐to‐cell communication key factors in cell adaptation response microenvironment. They collectively determine state function through modulating gene expression, changing energy nutrient demands. In addition, engage networks other components, which mediated exosomes, cytokines, chemokines, pivotal shaping progression response. Understanding interactions combined effects such multidimensions modulation important for revealing failure developing targets strategies.

Language: Английский

---

Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 10, 2024

Glioblastoma (GBM) is a highly malignant, invasive, and poorly prognosed brain tumor. Unfortunately, active comprehensive treatment does not significantly prolong patient survival. With the deepening of research, it has been found that gut microbiota plays certain role in GBM, can directly or indirectly affect efficacy immune checkpoint inhibitors (ICIs) various ways. (1) The metabolites produced by host’s homeostasis, these function distribution cells, promote inhibit inflammatory responses, phenotype, angiogenesis, response, cell infiltration GBM thereby affecting effectiveness ICIs. (2) Some members may reverse T inhibition, increase anti-tumor activity, ultimately improve ICIs targeting specific immunosuppressive cytokines. (3) participate metabolic process drugs, which degrade, transform, produce metabolites, effective concentration bioavailability drugs. Optimizing structure help (4) also regulate status through axis communication, progression therapeutic response to (5) Given importance for ICI therapy, researchers have begun exploring use fecal transplantation (FMT) transplant healthy optimized patients, order their enhance therapy. Preliminary studies suggest FMT therapy some patients. In summary, crucial regulating with deeper understanding relationship between tumor immunity, expected develop more precise personalized strategies prognosis.

Language: Английский

---

Bio-gel nanoarchitectonics in tissue engineering

Nanoscale, Journal Year: 2024, Volume and Issue: 16(28), P. 13230 - 13246

Published: Jan. 1, 2024

Nanoarchitectonics may be highly compatible with applications in biological systems. Construction strategies and functions of bio-gel nanoarchitectonics medical tissue engineering are discussed.

Language: Английский

---

Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pylori

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Helicobacter pylori (H. pylori) infection is the main risk for gastric cancer (GC). However, cellular heterogeneity and underlying molecular mechanisms in H. pylori-driven tumorigenesis are poorly understood.

Language: Английский

---

Anti-stromal nanotherapeutics for hepatocellular carcinoma

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 500 - 514

Published: Feb. 3, 2024

Language: Английский

---