Lipid mediators in neutrophil biology: inflammation, resolution and beyond DOI

Anita Ghodsi,

Andrés Hidalgo, Stephania Libreros

et al.

Current Opinion in Hematology, Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Purpose of review Acute inflammation is the body's first defense in response to pathogens or injury. Failure efficiently resolve inflammatory insult can severely affect tissue homeostasis, leading chronic inflammation. Neutrophils play a pivotal role eradicating infectious pathogens, orchestrating initiation and resolution acute inflammation, maintaining physiological functions. The highly orchestrated biochemical process, partially modulated by novel class endogenous lipid mediators known as specialized pro-resolving (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR). Recent findings This focuses on recent advances understanding multifaceted functions SPMs, detailing roles expediting neutrophil apoptosis, promoting clearance macrophages, regulating excessive infiltration at sites, bone marrow deployment, also enhances phagocytosis repair mechanisms under both pathological conditions. We focus functions, differentiation, highlight open questions about SPMs’ heterogeneity. Summary mitigating hyperactivity within milieus, notably conditions such sepsis, cardiovascular disease, ischemic events, cancer. significant function highlights promising therapeutic agents management disorders.

Language: Английский

Why do patients with cancer die? DOI
Adrienne Boire, Katy Burke, Thomas R. Cox

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(8), P. 578 - 589

Published: June 19, 2024

Language: Английский

Citations

29
Crosstalk Between the Nervous System and Tumor Microenvironment: Functional Aspects and Potential Therapeutic Strategies DOI
Lei Wang, Jingjing Ge,

Huiqiong Han

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 594, P. 216986 - 216986

Published: May 24, 2024

Language: Английский

Citations

18
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment DOI Creative Commons

Qibo Huang,

Bai Hu,

Zhang Ping

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 17, 2025

The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected tumorigenesis. In particular, peripheral central nervous systems, synapse, neurotransmitters, neurotrophins affect progression metastasis through various regulatory approaches immune microenvironment. this review, we summarized tumorigenesis metastasis, which controlled by systems. We also explored roles neurotransmitters progression. Moreover, examined interplay system have identified drugs target treatment. review present work supporting agent targeting could potential to improve therapy.

Language: Английский

Citations

2
Is it time to discard the Diagnostic and Statistical Manual of Mental Disorders (DSM) in psycho-oncology? DOI
Darren Haywood, Roman Kotov, Robert F. Krueger

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 589, P. 216818 - 216818

Published: March 28, 2024

Language: Английский

Citations

12
Convergent inducers and effectors of T cell paralysis in the tumour microenvironment DOI
Douglas Hanahan, Olivier Michielin, Mikaël J. Pittet

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Language: Английский

Citations

9
Neutrophil Extracellular Traps (NETs) as a Potential Target for Anti-Aging: Role of Therapeutic Apheresis DOI Creative Commons
Natalia Jarzebska, Roman N. Rodionov,

Karin Voit-Bak

et al.

Hormone and Metabolic Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Neutrophil extracellular traps (NETs) are large structures composed of chromatin, histones and granule-derived proteins released extracellularly by neutrophils. They generally considered to be a part the antimicrobial defense strategy, preventing dissemination pathogens. However, overproduction NETs or their ineffective clearance can drive various pathologies, many which associated with advanced age involve uncontrolled inflammation, oxidative, cardiovascular neurodegenerative stress as underlying mechanisms. Targeting in elderly an anti-aging therapy seems very attractive therapeutic approach. Therapeutic apheresis specific filter remove could promising strategy worth considering.

Language: Английский

Citations

1
Adaptations of neutrophils in cancer DOI
Melissa Ng, Daniela Cerezo‐Wallis, Lai Guan Ng

et al.

Immunity, Journal Year: 2025, Volume and Issue: 58(1), P. 40 - 58

Published: Jan. 1, 2025

Language: Английский

Citations

1
Neutrophil extracellular traps in tumor metabolism and microenvironment DOI Creative Commons

Z. Liu,

Yuanyao Dou, Conghua Lu

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 23, 2025

Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array physiological pathological activities, including immune rheumatic diseases damage to target organs. Recently, the connection between NETs cancer has garnered significant attention. Within tumor microenvironment metabolism, exhibit multifaceted roles, such as promoting proliferation migration cells, influencing redox balance, triggering angiogenesis, driving metabolic reprogramming. This review offers comprehensive analysis link emphasizing areas that remain underexplored. include interaction with mitochondria, their effect on states within tumors, involvement reprogramming, contribution angiogenesis tumors. Such insights lay theoretical foundation for deeper understanding role development. Moreover, also delves into potential therapeutic strategies suggests future research directions, offering new perspectives treatment other related diseases.

Language: Английский

Citations

1
Multilevel Stressors and Systemic and Tumor Immunity in Black and White Women With Breast Cancer DOI Creative Commons

Alexandra R. Harris,

Catherine M. Pichardo,

Jamirra Franklin

et al.

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(2), P. e2459754 - e2459754

Published: Feb. 14, 2025

Importance The mechanisms through which chronic stressors may be associated with tumor biologic characteristics, immune response, and health disparities remain insufficiently understood. Objective To investigate the proteomic, transcriptomic, genomic effects multilevel (perceived stress, perceived inadequate social support, racial ethnic discrimination, neighborhood deprivation) in Black White women breast cancer. Design, Setting, Participants This cross-sectional study was conducted from February 28, 2012, to September 5, 2023, blood samples, tumors, adjacent noncancerous tissues were collected Participants, recruited at 2 Baltimore, Maryland, hospitals, completed demographic psychosocial questionnaires. Data analysis 2023 April 2024. Exposures Perceived 2010 census tract-level deprivation index, scores range −2.51 6.77, higher indicating greater deprivation. Main Outcomes Measures main outcomes included levels of 92 circulating immune-oncologic markers pathways, cell profiles, tissue gene expression, mutational burden. analyzed using covariate-adjusted linear regression modeling for continuous effect estimates presented as β values 95% CIs. Results 121 cancer (mean [SD] age, 56.27 [12.62] years), whom 56 (46.3%) Black, 65 (53.7%) White. analytic subsample sizes 117 48 41 tissues. Levels stress support comparable by race, while resided more socioeconomically deprived neighborhoods 2.28 [2.30] compared −0.22 [2.01] women). Greater favorable immune-stimulatory changes (eg, increased serum IL-5 [β, 0.06 (95% CI, 0.02-0.10); P = .003] activated natural killer cells 0.11 0.04-0.17); .002). Higher exposure systemic inflammation IL-6 both 0.04 0.01-0.07); .006] discrimination 0.69 0.15-1.23); .01]); deleterious profiles tumor-associated M2 macrophages 0.82 0.14-1.51); .02]); aggressive characteristics. Race-stratified analyses uncovered distinct immunologic features stressors, including chemotaxis (β, 0.28 [95% 0.001-0.56]; .049) suppression 0.37 −0.002 0.75]; .05) level myeloid (monocytes M1 macrophages) level. elevated burden 0.02 0.01-0.04]; .04). Conclusions Relevance findings this suggest that alterations environment, particularly women. Understanding biology a possible mediator inform prevention public interventions.

Language: Английский

Citations

1
Intratumour oxidative hotspots provide a niche for cancer cell dissemination DOI
Yoshifumi Ueda, Shigeki Kiyonaka, Laura M. Selfors

et al.

Nature Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский

Citations

1