2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione mediates the effect of ROS‐enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer DOI Creative Commons
Liang Chen, Meifeng Chen, Yan Xie

et al.

FEBS Open Bio, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Several studies have suggested a potential antitumor effect of 2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione (DMDD). To further understand the mechanism action this compound, we investigated its on phosphatidylinositol‐3‐kinase (PI3K)/serine–threonine kinase (Akt)/mammalian target rapamycin (mTOR) signaling pathway. We show that DMDD application significantly inhibited proliferation breast cancer cell lines MDA‐MB‐231 and ER‐α positive MCF‐7. Furthermore, resulted in increased intracellular reactive oxygen species (ROS) levels, apoptosis autophagy, whereas it downregulated expression PI3K, Akt mTOR mRNA proteins, LC3II/I p62 proteins. In mouse xenograft model, tumor growth. Expression analyses suggest ROS levels were higher treated tissues, immunohistochemical apoptotic cells more prevalent group compared to control group. Taken together, our results molecular may involve enhancement autophagy through PI3K/Akt/mTOR pathway by mediating expression.

Language: Английский

Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases DOI Creative Commons
Francisco Javier Rodríguez‐Baena, Ángel Márquez-Galera,

Pablo Ballesteros-Martinez

et al.

Cancer Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

2
Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors DOI Creative Commons
Leire Bejarano, João Lourenço,

Annamaria Kauzlaric

et al.

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Multidimensional single-cell analysis: Diverse strategies and emerging applications in the life sciences DOI
Boyang Zhang,

Xinyue Lan,

Siyuan Tan

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118170 - 118170

Published: Jan. 1, 2025

Language: Английский

Citations

0
Lipid metabolic reprograming: the unsung hero in breast cancer progression and tumor microenvironment DOI Creative Commons
Mengting Wan,

Shuaikang Pan,

Benjie Shan

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 3, 2025

Aberrant lipid metabolism is a well-recognized hallmark of cancer. Notably, breast cancer (BC) arises from lipid-rich microenvironment and depends significantly on metabolic reprogramming to fulfill its developmental requirements. In this review, we revisit the pivotal role in BC, underscoring impact progression tumor microenvironment. Firstly, delineate overall landscape highlighting roles patient prognosis. Given that lipids can also act as signaling molecules, next describe exchanges between BC cells other cellular components Additionally, summarize therapeutic potential targeting aspects processes, lipid-related transcription factors immunotherapy BC. Finally, discuss possibilities problems associated with clinical applications lipid‑targeted therapy propose new research directions advances spatiotemporal multi-omics.

Language: Английский

Citations

0
Neuro–astrocytic network in breast cancer brain metastases: Adaptive mechanisms and novel therapeutic targets DOI

Tao Huang,

Dongbo Wu, Lu Jiang

et al.

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Breast cancer brain metastases (BrM) are a common and fatal complication in advanced breast patients, with the intricate microenvironment significantly limiting efficacy of current therapeutic strategies. Recently, neuro-astrocytic network, as core component metastasis microenvironment, has garnered extensive attention for its pivotal role supporting tumor adaptive growth. This review systematically outlines mechanisms network BrM, including bidirectional interactions between cells, neurons, astrocytes, their profound effects on synapse-like signaling, metabolic pathways, regulatory networks. Furthermore, we integrate recent advancements exploring targets discuss potential intervention strategies against tumor-microenvironment associated challenges. Future research focusing multi-target collaborative within this clinical translational may provide new avenues precise treatment BrM.

Language: Английский

Citations

0
Architecture sets the path: Breast cancer subtypes differently shape the early brain metastatic niche DOI

Menno Boon,

Leila Akkari

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(10), P. 1643 - 1645

Published: Sept. 26, 2024

Language: Английский

Citations

1
2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione mediates the effect of ROS‐enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer DOI Creative Commons
Liang Chen, Meifeng Chen, Yan Xie

et al.

FEBS Open Bio, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Several studies have suggested a potential antitumor effect of 2‐dodecyl‐6‐methoxycyclohexa‐2,5‐diene‐1,4‐dione (DMDD). To further understand the mechanism action this compound, we investigated its on phosphatidylinositol‐3‐kinase (PI3K)/serine–threonine kinase (Akt)/mammalian target rapamycin (mTOR) signaling pathway. We show that DMDD application significantly inhibited proliferation breast cancer cell lines MDA‐MB‐231 and ER‐α positive MCF‐7. Furthermore, resulted in increased intracellular reactive oxygen species (ROS) levels, apoptosis autophagy, whereas it downregulated expression PI3K, Akt mTOR mRNA proteins, LC3II/I p62 proteins. In mouse xenograft model, tumor growth. Expression analyses suggest ROS levels were higher treated tissues, immunohistochemical apoptotic cells more prevalent group compared to control group. Taken together, our results molecular may involve enhancement autophagy through PI3K/Akt/mTOR pathway by mediating expression.

Language: Английский

Citations

0