Designing a microbial fermentation-functionalized alginate microsphere for targeted release of 5-ASA using nano dietary fiber carrier for inflammatory bowel disease treatment DOI Creative Commons
Lei Qiu,

Renbin Shen,

Lei Wei

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 23, 2023

Abstract Patients with inflammatory bowel disease (IBD) always suffer from severe abdominal pain and appear to be at high risk for colorectal cancer. Recently, the co-delivery of targeted drugs gut microbiota has developed into an attractive strategy. A new strategy using fermentation overcome interspace diffuse resistance mucus layer control drug release in sites (IBS sites) not yet been available. Here, we designed alginate hydrogel microsphere encapsulating bifidobacterium (Bac) drug-modified nanoscale dietary fibers (NDFs). The is responsible protecting acidic multi-enzymatic environments delivering colorectum. Subsequently, Bac by digesting NDFs proteins as carbon nitrogen sources can promote play a probiotic role microbiota. In vitro evidence indicated that small-sized NDF (NDF-1) could significantly short-chain fatty acid (SCFA) expression. Notably, NDF-1 microspheres showed boost 5-ASA IBS sites, resulting amelioration inflammation remodeling chronic colitis mice. This study controlled system based on microbial treatment IBD.

Language: Английский

An Orally-Administered Nanotherapeutics with Carbon Monoxide Supplying for Inflammatory Bowel Disease Therapy by Scavenging Oxidative Stress and Restoring Gut Immune Homeostasis DOI
Xu Zhang, Zhang Yuan, Jianshuang Wu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 21116 - 21133

Published: Oct. 16, 2023

Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant limitations due to their potential off-target systemic side-effects. Currently, there is a lack of understanding on how effectively address excessive oxidative stress, dysregulated immune homeostasis, and microbiota dysbiosis within the IBD microenvironment. Herein, we introduce nanotherapeutic approach, named LBL-CO@MPDA, treatment. LBL-CO@MPDA an orally administered formulation that supplies carbon monoxide (CO) therapeutic purposes. To create nanocomposite, developed layer by (LBL) self-assembly strategy where coated chitosan/alginate polyelectrolytes onto surface CO prodrug-loaded mesoporous polydopamine nanoparticles (CO@MPDA). Benefiting from negatively charged LBL coating, it allows targeted accumulation specifically positively inflamed colon lesions through electrostatic interactions. Furthermore, in microenvironment colon, system releases responsive manner. Interestingly, CO@MPDA ameliorates conditions MPDA-mediated ROS-scavenging CO-mediated immunomodulation. CO-supplying activates heme oxygenase-1, leading macrophage M2 polarization via Notch/Hes1/Stat3 signaling pathway, while suppressing response down-regulating p38 MAPK NF-κB (p50/p65) pathways. In mice model dextran sulfate sodium (DSS)-induced IBD, reverses pro-inflammatory restores gut barrier functions multiple mechanisms, including scavenging restoring modulating microbiota. Collectively, our findings highlight promising this innovative treatment IBD.

Language: Английский

Citations

60
Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis DOI
Han Liu, Hao Zhang, Sicheng Wang

et al.

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 255, P. 110610 - 110610

Published: Feb. 13, 2023

Language: Английский

Citations

55
H2S‐Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation DOI Creative Commons
Ting Jin, Hongyang Lu, Qiang Zhou

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 2, 2024

Abstract Abnormal activation of the intestinal mucosal immune system, resulting from damage to barrier and extensive invasion by pathogens, contributes pathogenesis inflammatory bowel disease (IBD). Current first‐line treatments for IBD have limited efficacy significant side effects. An innovative H 2 S‐releasing montmorillonite nanoformulation (DPs@MMT) capable remodeling homeostasis, repairing barrier, modulating gut microbiota is developed electrostatically adsorbing diallyl trisulfide‐loaded peptide dendrimer nanogels (DATS@PDNs, abbreviated as DPs) onto (MMT) surface. Upon rectal administration, DPs@MMT specifically binds covers damaged mucosa, promoting accumulation subsequent internalization DPs activated cells in site. release S intracellularly response glutathione, initiating multiple therapeutic In vitro vivo studies shown that effectively alleviates colitis eliminating reactive oxygen species (ROS), inhibiting inflammation, eradicating pathogens. RNA sequencing revealed exerts immunoregulatory repair effects, activating pathways such Nrf2/HO‐1, PI3K‐AKT, RAS/MAPK/AP‐1, p38/ERK MAPK, p65 NF‐κB, JAK‐STAT3 pathways, well glycolysis. 16S rRNA demonstrated remodels pathogens increasing probiotics. This study develops a promising management.

Language: Английский

Citations

39
Bioactive mesoporous silica nanoparticle-functionalized titanium implants with controllable antimicrobial peptide release potentiate the regulation of inflammation and osseointegration DOI

Jiyu Dong,

Fangman Chen,

Yuying Yao

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 305, P. 122465 - 122465

Published: Jan. 2, 2024

Language: Английский

Citations

28
A Gas Therapy Strategy for Intestinal Flora Regulation and Colitis Treatment by Nanogel‐Based Multistage NO Delivery Microcapsules DOI
Yajun Fu, Xing Zhao, Liya Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(19)

Published: Feb. 7, 2024

Current approaches to treating inflammatory bowel disease focus on the suppression of overactive immune responses, removal reactive intestinal oxygen species, and regulation flora. However, owing complex structure gastrointestinal tract influence mucus, current small-molecule biologic-based drugs for colitis cannot effectively act at site colon inflammation, as a result, they tend exhibit low efficacies toxic side effects. In this study, nanogel-based multistage NO delivery microcapsules are developed achieve release inflammation by targeting tissues using nanogel. Surprisingly, oral administration suppresses growth pathogenic bacteria increases abundance probiotic bacteria. Metabolomics further show that an increased probiotics promotes production metabolites, including short-chain fatty acids indole derivatives, which modulate immunity restore barrier via interleukin-17 PI3K-Akt signaling pathways. This work reveals gas therapy strategy based modulates microbial balance, thereby reducing promoting repair, ultimately providing new therapeutic approach clinical management colitis.

Language: Английский

Citations

26
Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease DOI Creative Commons

Zhangpeng Shi,

Xiaohong Li,

Jufeng Chen

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 167 - 180

Published: Jan. 28, 2024

Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks and microbial imbalance play critical roles in the development of bowel disease (IBD). Herein, a novel enzyme-like biomimetic oral-agent ZnPBA@YCW has been developed, using yeast cell wall (YCW) as outer shell zinc-doped Prussian blue analogue (ZnPBA) nanozyme inside. When orally administered, is able to adhere

Language: Английский

Citations

24
An Engineered Nanoplatform with Tropism Toward Irradiated Glioblastoma Augments Its Radioimmunotherapy Efficacy DOI
Zheng Wang, Fangman Chen, Yi Cao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: May 7, 2024

Combining radiotherapy with immune checkpoint blockade therapy offers a promising approach to treat glioblastoma multiforme (GBM), yet challenges such as limited effectiveness and immune-related adverse events (irAEs) persist. These issues are largely due the failure in targeting immunomodulators directly tumor microenvironment. To address this, biomimetic nanoplatform that combines genetically modified mesenchymal stem cell (MSC) membrane bioactive nanoparticle core for chemokine-directed radioimmunotherapy of GBM is developed. The CC chemokine receptor 2 (CCR2)-overexpressing MSC acts tactical tentacle achieve radiation-induced tropism toward abundant (CC motif) ligand (CCL2) irradiated gliomas. core, comprising diselenide-bridged mesoporous silica nanoparticles (MSNs) PD-L1 antibodies (αPD-L1), enables X-ray-responsive drug release radiosensitization. In two murine models orthotopic tumors, this reinvigorated immunogenic death, augmented efficacy specificity radioimmunotherapy, reduced occurrence irAEs. This study suggests strategy targeted delivery, presents potent enhances safety radio-immunotherapy.

Language: Английский

Citations

22
Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives DOI Open Access
Sanja Petrović, Bogdan Biță, Marcela Elisabeta Barbinta-Patrascu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5842 - 5842

Published: May 27, 2024

This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.

Language: Английский

Citations

22
A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells DOI
Chen Xiao, Xing Wang, Shiyou Li

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122763 - 122763

Published: Aug. 17, 2024

Language: Английский

Citations

18
Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics DOI Creative Commons
A. Chen, Ying Gong,

S. C. Wu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 1, 2025

Language: Английский

Citations

2