Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model DOI Creative Commons
Longlong Zhang, Yuefei Zhu, Xunbin Wei

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(8), P. 3427 - 3447

Published: Jan. 13, 2022

Platelets buoy up cancer metastasis via arresting cells, enhancing their adhesion, and facilitating extravasation through the vasculature. When deprived of intracellular granular contents, platelet decoys could prevent metastatic tumor formation. Inspired by these, we developed nanoplatesomes fusing membranes with lipid (P-Lipo) to restrain formation more efficiently. It was shown nanoplateletsomes bound circulating cells (CTC) efficiently, interfered CTC arrest vessel endothelial layers, epithelial-mesenchymal transition as nanodecoys. More importantly, in mouse breast model, decrease survival blood counteract growth efficiently inhibiting inflammation suppressing escape. Therefore, nanoplatelesomes might usher a new avenue suppress lung metastasis.

Language: Английский

Recent Advances in Metal-Organic Framework (MOF) Asymmetric Membranes/Composites for Biomedical Applications DOI Open Access
Farrokhfar Valizadeh Harzand,

Seyyed Navid Mousavi Nejad,

Aziz Babapoor

et al.

Symmetry, Journal Year: 2023, Volume and Issue: 15(2), P. 403 - 403

Published: Feb. 3, 2023

Metal-organic frameworks (MOFs) are a new class of porous crystalline materials composed metal and organic material. MOFs have fascinating properties, such as fine tunability, large specific surface area, high porosity. widely used for environmental protection, biosensors, regenerative medicine, medical engineering, cell therapy, catalysts, drug delivery. Recent studies reported various significant properties biomedical applications, detection In contrast, limitations low stability specificity in binding to the target. MOF-based membranes improve conventional by increasing area developing possibility MOF-ligand binding, while conjugated dramatically increase active functional groups. This special property makes them attractive biosensor fabrication, both spreading solubility components porosity can be changed. Asymmetric structure with potential field, due different characteristics on its two surfaces, adjusting size porosity, transfer rate selectivity, hydrophilicity hydrophobicity. MOF assisted asymmetric provide platform field. The latest version materials/membranes has several especially delivery, which will discussed this review, along their advantages, disadvantages, challenges.

Language: Английский

Citations

29
Biomimetic single-atom nanozyme system for efficient inhibition of gastric cancer ascites via SO2 gas-enhanced nanocatalytic cancer therapy DOI
Tao Chen, Xi Luo, Liwei Zhu

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 467, P. 143386 - 143386

Published: May 9, 2023

Language: Английский

Citations

21
Advanced nano drug delivery systems for neuroprotection against ischemic stroke DOI

Chenchen Xie,

Jun Liao, Ning Zhang

et al.

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(2), P. 109149 - 109149

Published: Sept. 27, 2023

Language: Английский

Citations

21
Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges DOI Creative Commons
Samreen Sadiq, Iltaf Khan,

Zhenyu Shen

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(22), P. 7674 - 7674

Published: Nov. 20, 2023

Pathogens cause infections and millions of deaths globally, while antipathogens are drugs or treatments designed to combat them. To date, multifunctional nanomaterials (NMs), such as organic, inorganic, nanocomposites, have attracted significant attention by transforming antipathogen livelihoods. They very small in size so can quickly pass through the walls bacterial, fungal, parasitic cells viral particles perform their antipathogenic activity. more reactive a high band gap, making them effective than traditional medications. Moreover, due some pathogen’s resistance currently available medications, performance NMs is becoming crucial. Additionally, prospective properties administration methods, eventually chosen for cutting-edge applications therapies, including drug diagnostic tools antipathogens. Herein, characteristics that facilitate identifying eliminating pathogens real-time. This mini-review analyzes antimicrobial investigates mode action. We also discussed challenges need be solved utilization

Language: Английский

Citations

21
A homologous and molecular dual-targeted biomimetic nanocarrier for EGFR-related non-small cell lung cancer therapy DOI Creative Commons
Bin Xu,

Fanjun Zeng,

Jialong Deng

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 27, P. 337 - 347

Published: April 19, 2023

The abnormal activation of epidermal growth factor receptor (EGFR) drives the development non-small cell lung cancer (NSCLC). EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked efficacy in patients with who have an EGFR mutation. However, free administration inadequate response vivo, only ∼3% demonstrating a complete clinical response. Consequently, we designed biomimetic nanoparticle (CMNP@Osi) comprising polymeric core tumor cell-derived membrane-coated shell that combines membrane-mediated homologous molecular targeting for targeted drug delivery, thereby supporting dual-target strategy enhancing efficacy. After intravenous injection, CMNP@Osi accumulates at sites displays enhanced uptake into cells based on targeting. Osimertinib subsequently released cytoplasm, where it suppresses phosphorylation upstream downstream AKT signaling pathway inhibits proliferation cells. Thus, this dual-targeting using nanocarrier can enhance molecular-targeted delivery improve

Language: Английский

Citations

18
Metal organic frameworks for wastewater treatment, renewable energy and circular economy contributions DOI Creative Commons
Simranjeet Singh,

Nikhita Sivaram,

Bidisha Nath

et al.

npj Clean Water, Journal Year: 2024, Volume and Issue: 7(1)

Published: Nov. 30, 2024

Metal-Organic Frameworks (MOFs) are versatile materials with tailorable structures, high surface areas, and controlled pore sizes, making them ideal for gas storage, separation, catalysis, notably wastewater treatment by removing pollutants like antibiotics heavy metals. Functionalization enhances their applications in energy conversion environmental remediation. Despite challenges stability cost, ongoing innovation MOFs contributes to the circular economy aligns Sustainable Development Goals.

Language: Английский

Citations

8
Human glioblastoma-derived cell membrane nanovesicles: a novel, cell-specific strategy for boron neutron capture therapy of brain tumors DOI Creative Commons

Alice Balboni,

Giorgia Ailuno, Sara Baldassari

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 20, 2024

Glioblastoma (GBM), one of the deadliest brain tumors, accounts for approximately 50% all primary malignant CNS therefore novel, highly effective remedies are urgently needed. Boron neutron capture therapy, which has recently repositioned as a promising strategy to treat high-grade gliomas, requires conspicuous accumulation boron atoms in cancer cells. With aim selectively deliver sodium borocaptate (BSH, 12 B atoms-including molecule already employed clinics) GBM cells, we developed novel cell membrane-derived vesicles (CMVs), overcoming limits natural extracellular drug carriers, while maintaining their inherent homing abilities that make them preferable fully synthetic nanocarriers. Purified membrane fragments, isolated from patient-derived stem-like cultures, were used prepare nanosized CMVs, retained some proteins specific parent cells and devoid potentially detrimental genetic material. In vitro tests evidenced targeting ability this nanosystem ruled out any cytotoxicity. The CMVs successfully loaded with BSH, by following two different procedures, i.e. sonication electroporation, demonstrating potential applicability therapy.

Language: Английский

Citations

6
Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy DOI Creative Commons

Zimo Liu,

Xuefei Zhou, Qi Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 13(1), P. 327 - 343

Published: May 13, 2022

Extended circulation of anticancer nanodrugs in blood stream is essential for their clinical applications. However, administered nanoparticles are rapidly sequestered and cleared by cells the mononuclear phagocyte system (MPS). In this study, we developed a biomimetic nanosystem that able to efficiently escape MPS target tumor tissues. The fabricated (TM-CQ/NPs) were coated with fibroblast cell membrane expressing necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL). Coating functionalized reduced endocytosis macrophages, but increased nanoparticle uptake cells. Importantly, coating specifically induced via interaction TRAIL its cognate death receptors. Meanwhile, encapsulated chloroquine (CQ) further suppressed synergized induce apoptosis. vigorous antitumor efficacy two mice models confirmed our was an effective approach address challenge cancer therapy. Together, TM-CQ/NPs provides feasible precisely tissues improve efficacy.

Language: Английский

Citations

27
Cell membrane-coated mesoporous silica nanorods overcome sequential drug delivery barriers against colorectal cancer DOI
Jie Wang, Hao Pan,

Jingyi Li

et al.

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(6), P. 107828 - 107828

Published: Sept. 17, 2022

Language: Английский

Citations

25
Cell membrane-engineered nanoparticles for cancer therapy DOI
Wenjing Liu, Yuanyu Huang

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(37), P. 7161 - 7172

Published: Jan. 1, 2022

Cell membrane-coating nanotechnology involves dressing synthetic nanoparticles (NPs) with membranes derived from different types of cells to endow the NPs properties a specific cell type and further achieve precise effective disease treatment. Of great interest is fact that sourced sources can give functions NPs. In this review, we comprehensively lay out major advantages several typical membranes, which are red blood (RBCs), platelets, neutrophils, immune cells, stem or cancer for selective fabrication novel nanotherapeutics their potential greatly advance development nanomedicine improve curative effect treatments.

Language: Английский

Citations

24