Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(11), P. 2341 - 2341
Published: Oct. 30, 2022
The
clinical
translation
of
therapeutic
peptides
is
generally
challenged
by
multiple
issues
involving
absorption,
distribution,
metabolism
and
excretion.
In
this
study,
a
macrophage
membrane-coated
poly(lactic-co-glycolic
acid)
(PLGA)
nanodelivery
system
was
developed
to
enhance
the
bioavailability
somatostatin
(SST)
peptide,
which
faces
hurdles
short
half-life
potential
side
effects
in
treatment
chronic
pancreatitis.
Using
facile
nanoprecipitation
strategy,
SST
loaded
nanoparticles
with
an
encapsulation
efficiency
(EE)
loading
(LE)
73.68
±
3.56%
1.47
0.07%,
respectively.
final
formulation
SST-loaded
camouflage
membrane
(MP-SST)
showed
mean
diameter
151
4
nm
average
zeta
−29.6
0.3
mV,
were
stable
long
term
during
storage.
With
above
90%
cell
viability,
hemolysis
level
about
2%
(<5%)
preference
for
being
ingested
activated
endothelial
cells
compared
macrophages,
membrane−polymer
hybrid
nanoparticle
biocompatibility
targeting
capability
vitro.
After
intravenously
administered
mice
pancreatitis,
MP-SST
increased
content
serum
(123.6
13.6
pg/mL)
pancreas
(1144.9
206.2
pg/g)
(Dulbecco’s
phosphate-buffered
saline)
DPBS
(61.7
6.0
pg/mL
740.2
172.4
pg/g
pancreas).
recovery
downregulated
expressions
pancreatitis-related
factors
alleviated
histologic
severity
greatest
extent
other
groups.
This
augmentation
demonstrated
superiority
integrating
synthetic
polymer
biological
membranes
design
nanoplatforms
advanced
smart
peptide
delivery.
Other
like
can
also
be
delivered
via
nanosystem
diseases,
broadening
promoting
applications
as
therapeutics.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
20, P. 100633 - 100633
Published: April 12, 2023
With
the
development
of
nanotechnology,
nanoparticles
have
emerged
as
a
delivery
carrier
for
tumor
drug
therapy,
which
can
improve
therapeutic
effect
by
increasing
stability
and
solubility
prolonging
half-life
drugs.
However,
are
foreign
substances
humans,
easily
cleared
immune
system,
less
targeted
to
tumors,
may
even
be
toxic
body.
As
natural
biological
material,
cell
membranes
unique
properties,
such
good
biocompatibility,
strong
targeting
ability,
ability
evade
surveillance,
high
drug-carrying
capacity.
In
this
article,
we
review
membrane-coated
(CMNPs)
their
applications
therapy.
First,
briefly
describe
CMNP
characteristics
applications.
Second,
present
advantages
different
well
nanoparticles,
provide
brief
description
process
CMNPs,
discuss
current
status
application
summarize
shortcomings
use
in
cancer
propose
future
research
directions.
This
summarizes
progress
on
CMNPs
therapy
recent
years
assesses
remaining
problems,
providing
scholars
with
new
ideas
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(7), P. 2131 - 2141
Published: Jan. 16, 2024
Ischemia/reperfusion
(IR)-induced
acute
lung
injury
(ALI)
has
a
high
mortality
rate.
Reactive
oxygen
species
(ROS)
play
crucial
role
in
causing
cellular
damage
and
death
IR-induced
ALI.
In
this
work,
we
developed
biomimetic
lung-targeting
nanoparticle
(PC@MB)
as
an
antioxidative
protector
for
treating
PC@MBs
showed
excellent
ROS
scavenging
Nrf2
activation
properties,
along
with
function
through
autologous
cell
membrane
coating.
The
exhibited
impressive
pulmonary
protective
via
redox
homeostasis
recovery
heme
oxygenase-1
activation.
could
maintain
viability
by
effectively
the
intracellular
restoring
equilibrium
lesion.
IR
mouse
model,
preferentially
accumulated
distinctly
repaired
pneumonic
damage.
Our
strategy
potential
to
offer
promising
therapeutic
paradigm
ALI
incorporation
of
different
mechanisms.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: March 28, 2024
Abstract
Because
therapeutic
cancer
vaccines
can,
in
theory,
eliminate
tumor
cells
specifically
with
relatively
low
toxicity,
they
have
long
been
considered
for
application
repressing
progression.
Traditional
containing
a
single
or
few
discrete
epitopes
failed
the
clinic,
possibly
due
to
challenges
epitope
selection,
target
downregulation,
cell
heterogeneity,
microenvironment
immunosuppression,
lack
of
vaccine
immunogenicity.
Whole
membrane
vaccines,
which
provide
rich
source
antigens,
are
emerging
as
viable
alternatives.
Autologous
and
allogenic
cellular
evaluated
clinical
treatments.
Tumor
membranes
(TCMs)
an
intriguing
antigen
source,
membrane‐accessible
targets
and,
at
same
time,
serve
integrated
carriers
adjuvants
other
agents.
This
review
provides
summary
properties
technologies
TCM
vaccines.
Characteristics,
categories,
mechanisms,
preparation
methods
discussed,
demonstrable
additional
benefits
derived
from
combining
chemotherapy,
sonodynamic
therapy,
phototherapy,
oncolytic
viruses.
Further
research
chemistry,
biomedicine,
immunology,
bioinformatics
address
current
drawbacks
could
facilitate
adoption
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
367, P. 300 - 315
Published: Jan. 30, 2024
Nanoparticle
formulations
blending
optical
imaging
contrast
agents
and
therapeutics
have
been
a
cornerstone
of
preclinical
theranostic
applications.
However,
nanoparticle-based
theranostics
clinical
translation
faces
challenges
on
reproducibility,
brightness,
photostability,
biocompatibility,
selective
tumor
targeting
penetration.
In
this
study,
we
integrate
multimodal
within
cancer
cell-derived
nanovesicles,
leading
to
biomimetic
bright
optotheranostics
for
monitoring
metastasis.
Upon
NIR
light
irradiation,
the
engineered
enables
deep
visualization
precise
localization
metastatic
lung,
liver,
solid
breast
tumors
along
with
ablation.
Metastatic
nanovesicles
(∼80
±
5
nm)
are
encapsulate
(emissive
organic
dye
gold
nanoparticles)
therapeutic
(anticancer
drug
doxorubicin
photothermally
active
indocyanine
green
dye).
Systemic
administration
optotheranostic
nanoparticles
shows
escape
from
mononuclear
phagocytic
clearance
(i)
rapid
accumulation
(3
h)
retention
(up
168
h),
(ii)
real-time
(iii)
3-fold
image-guided
reduction.
These
findings
supported
by
an
improvement
X-ray,
fluorescence,
photoacoustic
signals
while
demonstrating
reduction
(201
mm3)
in
comparison
single
therapies
that
includes
chemotherapy
(134
mm3),
photodynamic
therapy
(72
photothermal
(88
mm3).
The
proposed
innovative
platform
opens
new
avenues
improve
diagnosis
treatment
outcomes
allowing
monitorization
metastasis,
imaging,
delivering
synergistic
at
site.
Abstract
Gastrointestinal
cancers,
a
major
global
cause
of
cancer‐related
mortality
and
disease
burden,
are
heterogeneous
group
malignant
aliments
involving
different
organs
the
digestive
system.
The
late
clinical
diagnosis,
genomic
tumor
heterogeneity,
high
complexity
gastrointestinal
microenvironment,
along
with
increasing
treatment
resistance
have
been
recognized
as
main
contributing
factors
to
current
inadequacy
interventions
poor
prognosis
cancer
patients.
In
coming
years,
is
unfortunately
predicted
increase
due
absence
early
detection
effective
therapeutic
options.
Biomembrane‐coated
biomimetic
nanoparticles
(NPs)
recently
appointed
advanced
nanotechnological
tools
for
management
cancers.
These
comprise
not
only
cell‐mimicking
nanodevices
(the
pioneers
this
top‐down
coating
technology),
but
also
exosome
bacterial
mimetics.
Due
their
enhanced
bio‐interfacing
features,
biocompatibility,
immune
evasion,
specific
targetability
tumorous
tissues,
these
nanostructures
successfully
exploited
provide
safer,
effective,
targeted
applications.
This
review
highlights
latest
research
on
biomembrane‐coated
nanosystems
therapy
diagnosis
most
common
deadliest
subtypes
namely
colorectal
cancer,
gastric
liver
esophageal
pancreatic
cancer.
challenges
toward
translation
mentioned.
