Applied Sciences,
Journal Year:
2024,
Volume and Issue:
14(3), P. 1132 - 1132
Published: Jan. 29, 2024
Magnetite-based
nanoparticles
are
of
constant
interest
in
the
scientific
community
as
potential
systems
for
biomedical
applications.
Over
years,
ability
to
synthesize
diverse
based
on
iron
(II,
III)
oxide
has
been
mastered
maximize
their
effectiveness
targeted
delivery
active
substances
cancer
therapy.
The
present
review
explores
recent
literature
findings
that
detail
various
magnetic
nanosystems.
These
encompass
straightforward
designs
featuring
a
polymer
coating
core
and
more
intricate
matrices
delivering
chemotherapeutic
drugs.
This
paper
emphasizes
novel
synthetic
approaches
impact
efficacy
progress
anticancer
investigations,
specifically
targeting
particular
type.
research
also
delves
into
combinations
with
alternative
treatment
methods
diagnostic
approaches.
Additionally,
it
highlights
critical
aspect—the
interaction
cells—identifying
least
developed
aspect
current
these
systems.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
23, P. 471 - 507
Published: Dec. 5, 2022
Remarkable
progress
in
phototherapy
has
been
made
recent
decades,
due
to
its
non-invasiveness
and
instant
therapeutic
efficacy.
In
addition,
with
the
rapid
development
of
nanoscience
nanotechnology,
systems
based
on
nanoparticles
or
nanocomposites
also
evolved
as
an
emerging
hotspot
nanomedicine
research,
especially
cancer.
this
review,
first
we
briefly
introduce
history
phototherapy,
mechanisms
cancer
treatment.
Then,
summarize
representative
over
past
three
five
years
nanoparticle-based
highlight
design
innovative
thereof.
Finally,
discuss
feasibility
potential
clinical
anticancer
applications,
aiming
predict
future
research
directions
field.
Our
review
is
a
tutorial
work,
at
providing
useful
insights
researchers
field
Small,
Journal Year:
2023,
Volume and Issue:
20(6)
Published: Sept. 29, 2023
Gene
therapy
(GT)
and
photothermal
(PTT)
have
emerged
as
promising
alternatives
to
chemotherapy
radiotherapy
for
cancer
treatment,
offering
noninvasiveness
reduced
side
effects.
However,
their
efficacy
standalone
treatments
is
limited.
GT
exhibits
slow
response
rates,
while
PTT
confined
local
tumor
ablation.
The
convergence
of
PTT,
known
GT-PTT,
facilitated
by
gene
nanocarriers,
has
attracted
considerable
attention
across
various
disciplines.
In
this
integrated
approach,
reciprocates
sensitizing
cellular
heat,
benefits
improving
translocation,
unpacking,
expression.
Consequently,
integration
presents
a
unique
opportunity
with
rapid
improved
effectiveness.
Extensive
efforts
over
the
past
few
years
been
dedicated
development
resulting
in
notable
achievements
progress
from
laboratory
potential
clinical
applications.
This
comprehensive
review
outlines
recent
advances
including
synergistic
mechanisms,
material
systems,
imaging-guided
therapy,
anticancer
It
also
explores
challenges
future
prospects
nascent
field.
By
presenting
innovative
ideas
insights
into
implementation
GT-PTT
enhanced
aims
inspire
further
area
research.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 8, 2024
Abstract
Acute
lung
injury
(ALI)
is
a
life
threatening
disease
in
critically
ill
patients,
and
characterized
by
excessive
reactive
oxygen
species
(ROS)
inflammatory
factors
levels
the
lung.
Multiple
evidences
suggest
that
nanozyme
with
diversified
catalytic
capabilities
plays
vital
role
this
fatal
injury.
At
present,
we
developed
novel
class
of
polydopamine
(PDA)
coated
cerium
dioxide
(CeO
2
)
(Ce@P)
acts
as
potent
ROS
scavenger
for
scavenging
intracellular
suppressing
responses
against
ALI.
Herein,
aimed
to
identify
Ce@P
combining
NIR
irradiation
could
further
strengthen
its
capacity.
Specifically,
triggered
exhibited
most
antioxidant
anti-inflammatory
behaviors
lipopolysaccharide
(LPS)
induced
macrophages
through
decreasing
levels,
down-regulating
TNF-α,
IL-1β
IL-6,
up-regulating
level
cytokine
(SOD-2),
inducing
M2
directional
polarization
(CD206
up-regulation),
increasing
expression
HSP70.
Besides,
performed
intravenous
(IV)
injection
LPS
ALI
rat
model,
found
it
significantly
accumulated
tissue
6
h
after
injection.
It
was
also
observed
+
presented
superior
inflammation,
alleviating
diffuse
alveolar
damage,
well
promoting
repair.
All
all,
has
strategy
using
synergistic
enhanced
treatment
ALI,
which
can
serve
promising
therapeutic
clinical
derived
diseases
well.
Biomaterials,
Journal Year:
2024,
Volume and Issue:
312, P. 122724 - 122724
Published: July 30, 2024
The
residual
bone
tumor
and
defects
which
is
caused
by
surgical
therapy
of
a
major
important
problem
in
clinicals.
And
the
sequential
treatment
for
irradiating
repairing
has
wildly
prospects.
In
this
study,
we
developed
general
modification
strategy
gallic
acid
(GA)-assisted
coordination
chemistry
to
prepare
black
calcium-based
materials,
combines
photothermal
defects.
GA
endows
materials
remarkable
properties.
Under
near-infrared
(NIR)
irradiation
with
different
power
densities,
GA-modified
matrix
(GBM)
did
not
merely
display
an
excellent
performance
eliminating
high
temperature,
but
showed
facile
effect
mild-heat
stimulation
accelerate
regeneration.
GBM
can
efficiently
regulate
microenvironments
regeneration
spatial-temporal
manner,
including
inflammation/immune
response,
vascularization
osteogenic
differentiation.
Meanwhile,
integrin/PI3K/Akt
signaling
pathway
marrow
mesenchymal
stem
cells
(BMSCs)
was
revealed
be
involved
osteogenesis
induced
stimulation.
outcome
study
only
provides
serial
new
multifunctional
biomaterials,
also
demonstrates
designing
novel
blacked
biomaterials
great
potential
clinical
use.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(44)
Published: May 25, 2024
Abstract
The
vigorous
development
of
cancer
nanomedicine
has
revolutionized
traditional
oncology
medicine,
but
it
is
also
limited
by
the
continuous
mutation
cunning
cells,
leading
to
apoptosis
insensitivity
and
therapeutic
disappointment.
Inflammatory‐regulated
cell
death
(RCD),
especially
pyroptosis‐related
death,
demonstrates
huge
potential
for
sensitization
due
its
unique
biochemical
characteristics.
aim
this
research
present
a
thorough
synopsis
current
knowledge
on
pyroptosis‐associated
inflammatory
including
pyroptosis,
cuproptosis,
PANoptosis,
synergistic
function
in
nano
therapy.
Paradigm
studies
death‐mediated
apoptosis‐sensitizing
tumor
nanotherapeutics
are
introduced
detail,
coordination
mechanisms
based
nanomaterials
discussed.
In
addition,
multi‐angle
analysis
future
prospects
pyroptosis‐sensitized
various
emphasized
further
expand
application
scope
RCD.
It
believed
that
emerging
auxiliary
treatments
RCD
will
greatly
promote
progress
nanomedicine.
Analytical Chemistry,
Journal Year:
2021,
Volume and Issue:
93(40), P. 13734 - 13741
Published: Oct. 4, 2021
Precisely
detecting
biomarkers
in
living
systems
holds
tremendous
promise
for
disease
diagnosis
and
monitoring.
Herein,
we
developed
a
covalent
organic
framework
(COF)-based
tricolor
fluorescent
nanoprobe
simultaneously
imaging
with
different
spatial
locations
cells.
Briefly,
TAMRA-labeled
survivin
mRNA
antisense
nucleotide
Cy5-labeled
transmembrane
glycoprotein
mucin
1
(MUC1)
aptamer
were
adsorbed
on
nanoscale
COF.
To
enhance
the
interactions
between
COF
nanoparticles
(NPs)
nucleic
acid
molecules,
freezing
method
was
employed
improving
loading
density
ensuring
detection
performance.
The
fluorescence
signals
of
dyes
DNAs
first
quenched
by
NPs.
Internalization
distribution
nanoprobes
can
be
real-time
visualized
autofluorescence
In
cells,
recognition
MUC1
aptamers
causes
signal
recovery
Cy5,
while
hybridization
its
DNA
induces
TAMRA.
Therefore,
this
COF-based
multicolor
could
visualizing
cell
membrane
cytoplasm.
Cancer
cell-specific
diagnostic
monitoring
process
cancer
exosomes
infecting
normal
cells
using
achieved.
This
work
not
only
offers
versatile
bioanalysis
but
also
provides
new
insights
developing
novel
nanoprobes.
