Synthesis,
Journal Year:
2023,
Volume and Issue:
55(13), P. 2091 - 2098
Published: Feb. 14, 2023
Abstract
A
novel
and
efficient
visible-light-induced
method
is
developed
for
the
one-pot
synthesis
of
functionalized
2-aminothiazoles
from
easily
accessible
active
methylene
ketone
derivatives
different
thioureas
at
room
temperature.
The
mild
reaction
conditions,
green
chemistry,
straightforward
work-up,
high
yields
products
make
this
procedure
useful
construction
2-aminothiazole
derivatives.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(9), P. 3543 - 3548
Published: Jan. 1, 2023
An
electrochemical
electrophilic
bromination/spirocyclization
of
N
-benzyl-acrylamides
to
brominated
2-azaspiro[4.5]decanes
with
2-bromoethan-1-ol
as
the
brominating
reagent
has
been
developed.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(4), P. 990 - 995
Published: Jan. 1, 2023
A
site-selective
electrochemical
C–H
bromination
of
(hetero)arenes
with
2-bromoethan-1-ol
by
releasing
available
ethylene
oxide
and
hydrogen
through
paired
electrolysis
has
been
developed.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(13), P. 8697 - 8708
Published: June 9, 2022
An
electrochemical
dearomatizing
spirocyclization
of
alkynes
with
dimethyl
2-benzylmalonates
for
the
preparation
spiro[4.5]deca-trienones
has
been
developed.
This
approach
adopts
ferrocene
(Cp2Fe)
as
an
electrocatalyst
to
produce
carbon-centered
radical
intermediates
from
C–H-based
malonates,
which
obviates
forthputting
noble-metal
reagents,
sacrificial
chemical
oxidants
and
2-bromomalonates.
A
wide
variety
spiro
compounds
are
efficiently
prepared
satisfactory
results
under
mild
conditions.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(10), P. 6562 - 6572
Published: April 29, 2022
A
novel
and
efficient
three-component
reaction
with
two
C–N
bonds
one
C–F
bond
formation
has
been
reported,
which
provides
a
straightforward
route
to
variety
of
fluorinated
pyrimido[1,2-b]indazole
derivatives.
This
transformation
the
advantage
excellent
functional
group
compatibility,
including
aliphatic
aromatic
substituents
enaminones.
Moreover,
metal
additives
are
not
necessary
for
this
reaction,
is
great
significance
synthesis
application
heterocycles.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(19), P. 13195 - 13203
Published: Sept. 15, 2022
Visible
light
photocatalytic
reactions
of
NH2-enaminones
and
ammonium
thiocyanate
for
chemoselective
α-C-H
thiocyanation
have
been
realized
the
first
time,
providing
a
sustainable
route
synthesis
thiocyanated
NH2-enaminones.
In
addition,
enaminone
products
can
be
flexibly
transformed
into
2-aminothiazoles
2-thiazolinones
via
simple
operation.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(39), P. 7118 - 7122
Published: Sept. 25, 2022
Herein,
a
photoinitiated
radical
relay
reaction
of
quinoxalin-2(1H)-ones,
with
acyloxy
nitroso
compounds
as
source
radicals,
is
described.
Although
the
C-H
functionalization
quinoxalin-2(1H)-ones
has
been
investigated,
its
difunctionalization,
simultaneous
construction
C-C
and
N-N
bonds
directly
via
reaction,
rarely
reported.
Moreover,
obtained
products
underwent
sequential
reactions
to
access
C7-NO2
under
mild
conditions.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(20), P. 3539 - 3543
Published: Aug. 26, 2022
Abstract
A
photoinduced
multicomponent
reaction
of
arylamines,
enaminones
and
difluorobromoacetates
for
the
synthesis
2,3‐difunctionalized
quinolines
is
reported.
This
strategy
features
broad
functional
groups
tolerance
wide
substrate
scopes
that
enables
further
synthetic
applications
obtained
products.
Mechanistic
studies
reveal
intermolecular
[3+3]
cyclization
between
in‐situ
generated
1,3‐vinylimine
ions
arylamines
key
step
in
this
transformation.
magnified
image
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(11), P. 2355 - 2360
Published: Jan. 1, 2023
Herein,
we
report
a
novel,
rapid
and
efficient
route
to
the
spiroquinazolinone
framework
via
an
umpolung
strategy
mediated
by
molecular
iodine.
A
library
of
functionalized
iodide
salts
was
synthesized
in
moderate
good
yields
under
ambient,
metal-free
mild
conditions.
The
current
methodology
opens
up
new
concise
for
construction
spiroquinazolinones.
