Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 166 - 166
Published: Jan. 26, 2025
Background:
Photothermal
therapy
has
the
potential
to
enhance
precision
and
safety
of
oncological
treatments.
However,
applicable
photothermal
agents
associated
with
its
activated
immunogenic
cell
death
remain
exploiting.
Methods:
This
study
evaluates
effectiveness
IR813,
a
agent,
combined
near-infrared
(NIR)
light
for
cancer
treatment.
In
vitro,
4T1
cells
were
treated
IR813
(5
μg/mL)
exposed
NIR
irradiation
(1
W/cm2)
5
min.
vivo,
after
tumor-bearing
mice
administered
mg/kg)
10
min,
tumor
volume,
survival
immune
activation
evaluated.
Results:
significantly
increased
cytotoxicity
following
irradiation,
resulting
in
release
damage-associated
molecular
patterns
death.
Specifically,
viability
was
reduced
5%
compared
control
group.
irradiating
accumulation
at
site
had
mediate
substantial
suppression,
improved
mouse
survival,
metastasis,
minimal
adverse
reactions.
Furthermore,
responses
stimulated
by
IR813-induced
evidenced
mature
dendritic
cytotoxic
T
lymphocyte
counts
decrease
regulatory
spleen,
tumor,
lymph
nodes.
Conclusions:
These
findings
suggest
that
is
promising
approach
enhancing
immunotherapy,
directly
inhibiting
tumors
while
boosting
systemic
anti-cancer
immunity.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(15)
Published: March 26, 2023
Abstract
The
regulation
of
tumor
immunosuppressive
microenvironments
via
precise
drug
delivery
is
a
promising
strategy
for
preventing
recurrence
and
metastasis.
Inspired
by
the
stealth
strategy,
stealthy
nanovehicle
based
on
neutrophil
camouflage
developed
to
achieve
immunotherapy
triggering
pyroptosis.
comprises
anti‐CD11b‐
IR820‐conjugated
bovine
serum
albumin
nanoparticles
loaded
with
decitabine.
Camouflaged
neutrophils,
nanovehicles
efficient
hitchhiking
owing
biotropism
neutrophils
tumors.
fluorescent
signal
molecule,
IR820,
acts
as
navigation
monitor
track
nanovehicle.
released
decitabine
upregulates
gasdermin
E,
laser
irradiation
activates
caspase‐3,
thereby
resulting
in
pyroptosis,
which
improves
system's
adaptive
immune
response.
In
triple‐negative
breast
cancer
animal
model,
it
regulates
microenvironment
effective
induces
long‐lasting
strong
memory
prevent
lung
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 571 - 608
Published: Jan. 1, 2024
Abstract:
With
the
development
of
nanotechnology,
nanoparticles
(NPs)
have
shown
broad
prospects
as
drug
delivery
vehicles.
However,
they
exhibit
certain
limitations,
including
low
biocompatibility,
poor
physiological
stability,
rapid
clearance
from
body,
and
nonspecific
targeting,
which
hampered
their
clinical
application.
Therefore,
novel
systems
with
improved
biocompatibility
high
target
specificity
remains
a
major
challenge.
In
recent
years,
biofilm
mediated
biomimetic
nano-drug
system
(BNDDS)
has
become
research
hotspot
focus
in
field
life
sciences.
This
new
platform
uses
bio-nanotechnology
to
encapsulate
synthetic
NPswithin
membrane,
organically
integrating
immunogenicity,
toxicity,
tumor
good
adjustability
versatility
nanocarrier,
shows
promising
applications
precision
therapy.
this
review,
we
systematically
summarize
progress
BNDDS
used
for
optimizing
delivery,
providing
theoretical
reference
designing
safe
efficient
treatment
strategies
improve
outcomes.
Keywords:
nanoparticles,
cell
targeted
therapy
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(19)
Published: Feb. 7, 2024
Neutrophils
are
the
most
abundant
white
blood
cells
in
circulation
and
act
as
first
line
of
defense
against
infections.
Increasing
evidence
suggests
that
neutrophils
possess
heterogeneous
phenotypes
functional
plasticity
human
health
diseases,
including
cancer.
play
multifaceted
roles
cancer
development
progression,
an
N1/N2
paradigm
is
proposed,
where
N1
exert
anti-tumor
properties
while
N2
display
tumor-supportive
immune-suppressive
functions.
Selective
activation
beneficial
neutrophil
population
targeted
inhibition
or
re-polarization
tumor-promoting
has
shown
important
potential
tumor
therapy.
In
addition,
due
to
natural
inflammation-responsive
physical
barrier-crossing
abilities,
their
derivatives
(membranes
extracellular
vesicles
(EVs))
regarded
advanced
drug
delivery
carriers
for
enhanced
targeting
improved
therapeutic
efficacy.
this
review,
recent
advances
engineering
remodeling
microenvironment
(TME)
comprehensively
presented.
This
review
will
provide
a
broad
understanding
Exploration,
Journal Year:
2024,
Volume and Issue:
4(4)
Published: Feb. 19, 2024
Abstract
Sonodynamic
therapy
(SDT)
has
been
explored
for
cancer
therapy,
especially
deep
tumors
due
to
its
low
tissue
penetration
restriction.
The
therapeutic
efficacy
of
SDT
is
limited
the
complicated
tumor
microenvironment.
This
study
reports
construction
oxygen‐carrying
semiconducting
polymer
nanoprodrugs
(OSPN
pro
)
treatment
via
combining
amplified
with
pyroptosis.
An
oxygen
carrier
perfluorohexane,
sonodynamic
as
sonosensitizer,
and
reactive
species
(ROS)‐responsive
prodrug
are
co‐loaded
into
a
nanoparticle
system,
leading
formation
these
nanoprodrugs.
Such
OSPN
show
an
effective
accumulation
in
tissues
after
systemic
administration,
which
they
deliver
relieve
hypoxia
microenvironment
thus
mediate
producing
ROS
under
ultrasound
(US)
irradiation,
even
when
covered
2‐cm
chicken
breast
tissue.
In
addition,
ROS‐responsive
prodrugs
activated
by
generated
trigger
pyroptosis
cells.
sono‐pyroptosis
induces
strong
antitumor
immunity
obviously
higher
level
infiltrations
effector
immune
cells
tumors.
Therefore,
‐based
combinational
can
greatly
inhibit
growth
tissue‐covered
suppress
metastasis.
offers
nanoplatform
strategy.
MedComm – Oncology,
Journal Year:
2024,
Volume and Issue:
3(1)
Published: March 1, 2024
Abstract
Rapid
growth
in
nanoparticles
(NPs)
as
delivery
systems
holds
vast
promise
to
promote
therapeutic
approaches
for
cancer
treatment.
Presently,
a
diverse
array
of
NPs
with
unique
properties
have
been
developed
overcome
different
challenges
and
achieve
sophisticated
routes
enhancement
series
therapies.
Inspiring
advances
achieved
the
field
therapy
using
NPs.
In
this
review,
we
aim
summarize
up‐to‐date
progression
addressing
various
challenges,
expect
elicit
novel
potential
opportunities
alternatively.
We
first
introduce
sorts
NP
technologies,
illustrate
their
mechanisms,
present
applications.
Then,
achievements
made
by
break
obstacles
delivering
cargoes
specific
sites
through
particular
are
highlighted,
including
long‐circulation,
tumor
targeting,
responsive
release,
subcellular
localization.
subsequently
retrospect
recent
research
treatments
from
single
therapy,
like
chemotherapy,
combination
chemoradiotherapy,
integrative
therapy.
Finally,
perspectives
impact
on
oncology
discussed.
believe
review
can
offer
deeper
understanding
Proceedings of the National Academy of Sciences,
Journal Year:
2024,
Volume and Issue:
121(9)
Published: Feb. 21, 2024
Photon-controlled
pyroptosis
activation
(PhotoPyro)
is
a
promising
technique
for
cancer
immunotherapy
due
to
its
noninvasive
nature,
precise
control,
and
ease
of
operation.
Here,
we
report
that
biomolecular
photoredox
catalysis
in
cells
might
be
an
important
mechanism
underlying
PhotoPyro.
Our
findings
reveal
the
photocatalyst
lutetium
texaphyrin
(
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(6), P. 4981 - 4992
Published: Jan. 9, 2024
During
wound
healing
after
cancer
surgery,
platelets,
neutrophils,
and
macrophages
accumulate
at
the
site
induce
important
pathophysiological
features.
Utilizing
these
features,
development
of
targeted
delivery
systems
for
postoperative
tumor
immunotherapy
is
an
strategy.
Herein,
a
twindrive
precise
system
hybrid
membrane
combined
with
CD47
blocking
developed
regulation
to
immunotherapy.
The
consists
IR820-modified
platelet-neutrophil
membranes
loaded
R848
nanoparticles.
Based
on
pathological
characteristics
platelet
aggregation
neutrophil
tendency
caused
by
inflammatory
microenvironment
could
achieve
immune
drugs
sites.
After
guided
fluorescence
imaging,
reprogram
M2
into
M1
macrophages,
stimulate
dendritic
cell
maturation
as
adjuvant,
then
activate
T
immunity.
polarization
blockade
together
enhanced
phagocytosis
function
which
cell-mediated
cellular
response
finally
effectively
inhibit
postsurgical
recurrence,
metastasis,
prolonged
survival
time.
It
develops
regulatory
cell-specific
responses
features
