Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(13), P. 6830 - 6859
Published: Jan. 1, 2024
This review presents the recent progress on aptamers that have been explored for SARS-CoV-2 detection and therapeutics, wherein construction principles characteristics of aptamer-based assembly systems are systematically summarized.
Language: Английский
Citations
15
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(8), P. 3291 - 3299
Published: Feb. 2, 2024
Lateral flow assay (LFA)-based rapid antigen tests are experiencing extensive global uptake as an expeditious and highly effective modality for the screening of viral infections during COVID-19 pandemic. While these devices have played a significant role in alleviating burden on public healthcare system, their specificity sensitivity fall short compared with molecular tests. In this study, we endeavor to address both limitations through utilization DNA nanotechnology LFA format, wherein substitute target-specific antibody designer nanostructure-based probes recognizing SARS-CoV-2 virus via multivalent, pattern-matching interactions. We meticulously designed Net-shaped nanostructure strategically arranged trimeric clusters aptamers that specifically recognize spike proteins SARS-CoV-2. This approach has proven instrumental bolstering virus-binding affinity LFAs. Our findings indicate high sensitivity, enabling detection loads ranging from 103 108 copies/mL. notable is maintained across various strains, obviating need intricate sample preparation protocols. The significance heightened lies crucial by nanostructure, which facilitates extremely low levels loads. not only enhances overall reliability self-testing but also reduces likelihood false-negative results, especially cases load within patient samples.
Language: Английский
Citations
8
Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(4)
Published: April 1, 2024
Language: Английский
Citations
8
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 3774 - 3828
Published: Jan. 1, 2024
Engineered 2D nanomaterials-based smartphone-assisted detection approaches integrated with IoMT, focusing on reliable, sensitive, and rapid diagnostics for COVID-19.
Language: Английский
Citations
7
Nano Letters, Journal Year: 2024, Volume and Issue: 24(12), P. 3614 - 3623
Published: March 18, 2024
Broad-spectrum antiviral platforms are always desired but still lack the ability to cope with threats global public health. Herein, we develop a poly aptamer encoded DNA nanocatcher platform that can trap entire virus particles inhibit infection broad spectrum. Ultralong single-stranded (ssDNA) containing repeated aptamers was synthesized as scaffold of via biocatalytic process, wherein mineralization magnesium pyrophosphate on ssDNA could occur and consequently lead formation interfacial nanocaves decorated virus-binding aptamers. Once viruses were recognized by apatmers, they would be captured trapped in multisite synergistic interactions. Meanwhile, size nanocatchers optimized prevent their cellular uptake, which further guaranteed inhibition infection. By taking SARS-CoV-2 variants model target, demonstrated virus-trapping capability engulfing blocking host cells.
Language: Английский
Citations
6
Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e29909 - e29909
Published: April 21, 2024
According to information from the World Health Organization, world has experienced about 430 million cases of COVID-19, a world-wide health crisis caused by SARS-CoV-2 virus. This outbreak, originating China in 2019, led nearly 6 deaths worldwide. As number confirmed infections continues rise, need for cutting-edge techniques that can detect early and accurately become more critical. To address this, Federal Drug Administration (FDA) issued emergency use authorizations (EUAs) wide range diagnostic tools. These include tests based on detecting nucleic acids antigen-antibody reactions. The quantitative real-time reverse transcription PCR (qRT-PCR) assay stands out as gold standard virus detection. However, despite its accuracy, qRT-PCR limitations, such complex testing protocols risk false negatives, which drive continuous improvement acid serological approaches. emergence highly contagious variants coronavirus, Alpha (B.1.1.7), Delta (B.1.617.2), Omicron (B.1.1.529), increased specifically identify these mutations. article explores both acid-based assays, assessing performance recently approved FDA those documented scientific research, especially identifying new coronavirus strains.
Language: Английский
Citations
4
European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 264, P. 115979 - 115979
Published: Nov. 25, 2023
Language: Английский
Citations
10
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136152 - 136152
Published: Jan. 1, 2025
Language: Английский
Citations
0
Archives of Pharmacal Research, Journal Year: 2025, Volume and Issue: unknown
Published: March 22, 2025
Language: Английский
Citations
0
Electronic Journal of Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0