Ferroptosis Photoinduced by New Cyclometalated Iridium(III) Complexes and Its Synergism with Apoptosis in Tumor Cell Inhibition

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(15), P. 8174 - 8181

Published: March 3, 2021

Limited therapeutic efficacy to hypoxic and refractory solid tumors has hindered the practical application of photodynamic therapy (PDT). Two new benzothiophenylisoquinoline (btiq)-derived cyclometalated IrIII complexes, IrL1 MitoIrL2, were constructed as potent photosensitizers, with latter being designed for mitochondria accumulation. Both complexes demonstrated a type I PDT process caused photoinduced ferroptosis in tumor cells under hypoxia. This featured lipid peroxide accumulation, shrinkage, down-regulation glutathione peroxidase 4 (GPX4), ferrostatin-1 (Fer-1)-inhibited cell death. Upon photoirradiation hypoxia, targeting MitoIrL2 membrane potential (MMP) collapse, ATP production suppression, induced apoptosis. The synergetic effect apoptosis causes outperform inhibiting growth MCF-7, PANC-1, MDA-MB-231 multicellular spheroids. study demonstrates first example by photosensitizing complexes. Moreover, synergism provides promising approach combating through processes.

Language: Английский

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Bioinspired Applications of Porphyrin Derivatives

Accounts of Chemical Research, Journal Year: 2021, Volume and Issue: 54(9), P. 2249 - 2260

Published: April 23, 2021

Porphyrin derivatives are ubiquitous in nature and have important biological roles, such as light harvesting, oxygen transport, catalysis. Owing to their intrinsic π-conjugated structure, porphyrin exhibit characteristic photophysical electrochemical properties. In systems, associated with various protein molecules through noncovalent interactions. For example, hemoglobin, which is responsible for transport most vertebrates, consists of four subunits a globular an iron derivative prosthetic group. Furthermore, noncovalently arranged the fundamental chromophores light-harvesting systems photosynthesis plants algae. These biologically roles originate from functional versatility derivatives. Specifically, porphyrins excellent host compounds, forming coordination complexes metal ions that adds functionality unit, redox activity additional ligand binding at central ion. addition, useful building blocks supramolecular assemblies because flat symmetrical molecular architectures, properties typically utilized fabrication bioactive materials. this Account, we summarize our endeavors over past decade develop materials based on using bioinspired approaches. first section, discuss several synthetic receptors act artificial allosteric can be used selective detection chemicals, cyanide, chloride, amino acids. second introduce multiporphyrin arrays mimics natural complexes. The active control energy transfer processes by guest organic photovoltaic devices also introduced. third types porphyrin-based assemblies. Through interactions metal-ligand interaction, hydrogen bonding, π-π were constructed polymers formation fiber or toroidal assembly. last application biomedical nanodevice Even though good candidates photosensitizers photodynamic therapy, they limitations owing aggregation aqueous media. We suggested ionic dendrimer showed therapy (PDT) efficacy.

Language: Английский

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Preparation of Photocatalytic and Antibacterial MOF Nanozyme Used for Infected Diabetic Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(16), P. 18194 - 18208

Published: April 12, 2022

Bacterial infection has been a considerable obstacle for diabetic wound healing. A multifunctional nanoplatform used as nanozyme bacterial infected is extremely attractive. Therefore, gold nanoclusters modified zirconium-based porphyrin metal-organic frameworks (Au NCs@PCN) were constructed by an in situ growth method. Through SEM, TEM, and EDS mapping, the surface of ellipsoid-shaped particles around 190 nm was observed to be evenly interspersed with 5-8 nanoclusters. Notably, Au NCs@PCN exhibits excellent performance exciting ROS generation photothermal effects. Under near-infrared (NIR) laser irradiation, can heated 56.2 °C produce ROS, showing effective killing effect on bacteria. Antibacterial studies showed that inhibited MRSA AmprE. coli destroying membrane structure inducing protein leakage up 95.3% 90.6%, respectively. Animal experiments treated rats had reduced coverage 2.7% within 21 days. The immunoblot analysis proangiogenic proepithelial cell proliferation factors expressed significantly up-regulated. These results prove photocatalytic activity broad application prospect promoting

Language: Английский

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Targeting drug delivery with light: A highly focused approach

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 171, P. 94 - 107

Published: Jan. 22, 2021

Language: Английский

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Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles

Bioactive Materials, Journal Year: 2021, Volume and Issue: 8, P. 20 - 34

Published: June 26, 2021

Photodynamic therapy (PDT) has been applied in clinical treatment of tumors for a long time. However, insufficient supply pivotal factors including photosensitizer (PS), light, and oxygen tumor tissue dramatically reduces the therapeutic efficacy PDT. Nanoparticles have received an influx attention as drug carriers, recent studies demonstrated their promising potential to overcome obstacles PDT tissue. Physicochemical optimization passive targeting, ligand modification active stimuli-responsive release achieved efficient delivery PS Various trials using upconversion NPs, two-photon lasers, X-rays, bioluminescence provided clues methods light deep Attempts made unfavorable microenvironments via artificial generation, Fenton reaction, combination with other chemical drugs. In this review, we introduce these creative approaches addressing hurdles facing tumors. particular, that validated animal experiments are preferred review over proof-of-concept were only performed cells.

Language: Английский

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Porphyrin-Containing MOFs and COFs as Heterogeneous Photosensitizers for Singlet Oxygen-Based Antimicrobial Nanodevices

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(23), P. 26651 - 26672

Published: June 4, 2021

Visible-light irradiation of porphyrin and metalloporphyrin dyes in the presence molecular oxygen can result photocatalytic generation singlet (1O2). This type II reactive species (ROS) finds many applications where dye, also called photosensitizer, is dissolved (i.e., homogeneous phase) along with substrate to be oxidized. In contrast, metal-organic frameworks (MOFs) are insoluble (or will disassemble) when placed a solvent. When stable as suspension, MOFs adsorb large amount O2 photocatalytically generate 1O2 heterogeneous process efficiently. Considering immense surface area great capacity for gas adsorption MOFs, they seem ideal candidates this application. Very recently, covalent-organic (COFs), variants reticulation relies on covalent rather than coordination bonds, have emerged efficient photosensitizers. comprehensive mini review describes recent developments use porphyrin-based or porphyrin-containing COFs, including nanosized versions, photosensitizers toward antimicrobial applications.

Language: Английский

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Corroles at work: a small macrocycle for great applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(4), P. 1277 - 1335

Published: Jan. 1, 2022

The review summarizes the exploitations of corrole derivatives in many different fields, where peculiar properties these contracted macrocycles lead to development promising applications.

Language: Английский

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Recent advances in engineered polymeric materials for efficient photodynamic inactivation of bacterial pathogens

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 157 - 174

Published: Aug. 21, 2022

Nowadays, infectious diseases persist as a global crisis by causing significant destruction to public health and the economic stability of countries worldwide. Especially bacterial infections remain most severe concern due prevalence emergence multi-drug resistance (MDR) limitations with existing therapeutic options. Antibacterial photodynamic therapy (APDT) is potential modality that involves systematic administration photosensitizers (PSs), light, molecular oxygen (O2) for coping infections. Although porphyrin non-porphyrin PSs were effective in APDT, poor solubility, limited efficacy against Gram-negative bacteria, non-specific distribution hinder their clinical applications. Accordingly, promote efficiency conventional PSs, various polymer-driven modification functionalization strategies have been adopted engineer multifunctional hybrid phototherapeutics. This review assesses recent advancements state-of-the-art research polymer-PSs materials developed APDT Further, key findings following aspects are considered in-depth constructive discussions: i) PSs-integrated/functionalized polymeric composites through interactions; ii) PSs-deposited coatings on different substrates devices eliminate healthcare-associated infections; iii) PSs-embedded films, scaffolds, hydrogels regenerative medicine

Language: Английский

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Research advances in BODIPY-assembled supramolecular photosensitizers for photodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215367 - 215367

Published: Aug. 25, 2023

Language: Английский

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Nanomaterials for photothermal cancer therapy

RSC Advances, Journal Year: 2023, Volume and Issue: 13(21), P. 14443 - 14460

Published: Jan. 1, 2023

This review summarizes the common inorganic and organic photothermal nanoagents their applications in tumor therapy. Additionally, challenges future prospects of nanomaterial-based therapy cancer treatment are discussed.

Language: Английский

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