Recent Advances in Dual‐Function Superhydrophobic Antibacterial Surfaces DOI

Dongxu Jia,

Yuancheng Lin, Yi Zou

et al.

Macromolecular Bioscience, Journal Year: 2023, Volume and Issue: 23(11)

Published: June 2, 2023

Abstract Bacterial adhesion and subsequent biofilm formation on the surfaces of synthetic materials imposes a significant burden in various fields, which can lead to infections patients or reduce service life industrial devices. Therefore, there is increasing interest imbuing with antibacterial properties. Bioinspired superhydrophobic high water contact angles (>150°) exhibit excellent surface repellency against contaminations, thereby preventing initial bacterial inhibiting formation. However, conventional typically lack long‐term durability are incapable achieving persistent efficacy adhesion. To overcome these limitations, recent decades, dual‐function both bacteria‐repelling bacteria‐killing properties have been developed by introducing bactericidal components. These demonstrated improved performance addressing issues associated surface‐attached bacteria. This review summarizes advancements surfaces. First, brief overview fabrication strategies mechanism provided then classified into three types based mechanism: i) mechanotherapy, ii) chemotherapy, iii) phototherapy. Finally, limitations challenges current research discussed future perspectives this promising area proposed.

Language: Английский

Biodegradable and Cytocompatible Hydrogel Coating with Antibacterial Activity for the Prevention of Implant-Associated Infection DOI

Yanhui Liu,

Ting Dong, Yuhang Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(9), P. 11507 - 11519

Published: Feb. 28, 2023

Implant-associated infection (IAI) caused by pathogens colonizing on the implant surface is a serious issue in trauma-orthopedic surgery, which often leads to failure. The complications of IAI bring big threat clinical practice implants, accompanied significant economic cost and long hospitalization time. In this study, we propose an antibiotics-free strategy address IAI-related challenges using biodegradable cytocompatible hydrogel coating. To achieve this, novel system was developed combine synergistic effects good cell affinity antibacterial properties. material prepared modifying photocross-linkable gelatin-based polymer (GelMA) with cationic quaternary ammonium salt (QAS) groups via mild simple synthesis procedure. By engineering length hydrophobic carbon chain QAS group degree functionalization, resulting GelMA-octylQAS exhibited integration mechanical properties, biodegradability, excellent bactericidal activity against various types bacteria, high cytocompatibility mammalian cells. When coated onto situ cross-linking procedure, our demonstrated superior antimicrobial ability infective model femoral fracture rats. Our results suggest that might provide promising platform for preventing treating IAI.

Language: Английский

Citations

68
M2 macrophage-derived exosome-encapsulated microneedles with mild photothermal therapy for accelerated diabetic wound healing DOI Creative Commons
Junkai Zeng, Zhenyu Sun,

Feihui Zeng

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100649 - 100649

Published: April 30, 2023

Due to local overactive inflammatory response and impaired angiogenesis, current treatments for diabetic wounds remain unsatisfactory. M2 macrophage-derived exosomes (MEs) have shown considerable potential in biomedical applications, especially since they anti-inflammatory properties that modulate macrophage phenotypes. However, exosome-based strategies still limitations, such as short half-lives instability. Herein, we develop a double-layer microneedle-based wound dressing system (MEs@PMN) by encapsulating MEs the needle tips polydopamine (PDA) nanoparticles backing layer simultaneously suppress inflammation improve angiogenesis at site.

Language: Английский

Citations

54
Functionalized nanoparticles: Tailoring properties through surface energetics and coordination chemistry for advanced biomedical applications DOI
Yogendra Kumar,

Amit Sinha,

K.D.P. Nigam

et al.

Nanoscale, Journal Year: 2023, Volume and Issue: 15(13), P. 6075 - 6104

Published: Jan. 1, 2023

Significant advances in nanoparticle-related research have been made the past decade, and amelioration of properties is considered utmost importance for improving nanoparticle bioavailability, specificity, catalytic performance. Nanoparticle can be tuned through in-synthesis post-synthesis functionalization operations, with thermodynamic kinetic parameters playing a crucial role. In spite robust techniques based on surface chemistry, scalable technologies not explored well. The coordination enhancement via organic/inorganic/biomolecules material has attracted much attention morphology modification shape tuning, which are indispensable aspects colloidal phase during biomedical applications. It envisioned that influences anchoring nano interfaces immobilization functional groups biomolecules. this work, various nanostructure methodologies discussed, aiming to exploit their full potential precision engineering Simultaneous discussions emerging characterization strategies functionalized assemblies gain insights into chemistry. An overview current prospects nanoparticles presented, an emphasis controllable attributes such as size, shape, morphology, functionality, features, Debye Casimir interactions.

Language: Английский

Citations

48
Molybdenum-based antimicrobial nanomaterials: A comprehensive review DOI
Jing Liao, Lei Wang, Shuaishuai Ding

et al.

Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101875 - 101875

Published: May 17, 2023

Language: Английский

Citations

47
Specific Chemiluminescence Imaging and Enhanced Photodynamic Therapy of Bacterial Infections by Hemin‐Modified Carbon Dots DOI

Ke Cheng,

Henggang Wang,

Shan Sun

et al.

Small, Journal Year: 2023, Volume and Issue: 19(31)

Published: March 25, 2023

Abstract Antibacterial photodynamic therapy (aPDT) is a promising antibiotics‐alternative strategy for bacterial infectious diseases, which features broad‐spectrum antibacterial activity with low risk of inducing resistance. However, clinical applications aPDT are still hindered by the hydrophobicity‐caused inadequate conventional photosensitizers and hypoxic microenvironment infections. To address these problems, herein, developed to achieve specific chemiluminescence (CL) imaging enhanced PDT infections using hemin‐modified carbon dots (H‐CDs). The H‐CDs can be facilely prepared exhibit favorable water solubility, augmented activity, unique peroxidase‐mimicking capacity. Compared free CDs, efficacy significantly due increased electron–hole separation efficiency. Moreover, peroxidase catalytic performance enables not only infection identification via microenvironment‐responsive CL but also oxygen self‐supplied hypoxia‐relief‐enhanced bacteria inactivation effects. Finally, efficiencies validated in both vivo abscess infected wound models. This work may provide an effective platform selective imaging‐guided treatment

Language: Английский

Citations

45
Nanoarchitectonics of Bimetallic Cu-/Co-Doped Nitrogen–Carbon Nanozyme-Functionalized Hydrogel with NIR-Responsive Phototherapy for Synergistic Mitigation of Drug-Resistant Bacterial Infections DOI
Shengnan Song, X Zhao,

Xiao-Chan Yang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 16011 - 16028

Published: March 26, 2024

Superbug infections and transmission have become major challenges in the contemporary medical field. The development of novel antibacterial strategies to efficiently treat bacterial conquer problem antimicrobial resistance (AMR) is extremely important. In this paper, a bimetallic CuCo-doped nitrogen–carbon nanozyme-functionalized hydrogel (CuCo/NC-HG) has been successfully constructed. It exhibits photoresponsive-enhanced enzymatic effects under near-infrared (NIR) irradiation (808 nm) with strong peroxidase (POD)-like oxidase (OXD)-like activities. Upon NIR irradiation, CuCo/NC-HG possesses photodynamic activity for producing singlet oxygen(1O2), it also high photothermal conversion effect, which not only facilitates elimination bacteria but improves efficiency reactive oxygen species (ROS) production accelerates consumption GSH. shows lower hemolytic rate better cytocompatibility than CuCo/NC positive charge macroporous skeleton restricting negatively charged range ROS destruction, strengthening efficiency. Comparatively, stronger bactericidal ability against methicillin-resistant Staphylococcus aureus (MRSA) ampicillin-resistant Escherichia coli (AmprE. coli) through destroying cell membranes negligible occurrence AMR. More importantly, plus can exhibit satisfactory performance absence H2O2, avoiding toxicity from high-concentration H2O2. vivo evaluation conducted using mouse wound infection model histological analyses, results show that upon suppress promote healing, without causing inflammation tissue adhesions.

Language: Английский

Citations

18
Research progress of natural polysaccharide-based and natural protein-based hydrogels for bacteria-infected wound healing DOI

XU Hui-qing,

Yilin Che,

Rui Zhou

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153803 - 153803

Published: July 6, 2024

Language: Английский

Citations

18
Strategy to Efficient Photodynamic Therapy for Antibacterium: Donor‐Acceptor Structure in Hydrogen‐Bonded Organic Framework DOI
Ying Zou, Haixiong Liu,

Lei Cai

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 24, 2024

While the construction of a donor-acceptor (D-A) structure has gained great attention across various scientific disciplines, such structures are seldomly reported within field hydrogen-bonded organic frameworks (HOFs). Herein, D-A based HOF is synthesized, where adjacent pairs connected by hydrogen bonds instead conventionally employed covalent bonds. This structural feature imparts material with reduced energy gap between excited state and triplet state, thereby facilitating intersystem crossing (ISC) boosting generation rate single oxygen (quantum yield = 0.98). Consequently, resulting shows high performance for antimicrobial photodynamic therapy (PDT). The impact moiety evident when comparing this finding to parallel study conducted on an isoreticular without structure. presented here provides in-depth insights into photophysical properties pair in network, opening new avenue design innovative materials efficient PDT.

Language: Английский

Citations

17
Nanomaterial-Based Strategies to Combat Antibiotic Resistance: Mechanisms and Applications DOI Creative Commons
Nargish Parvin, Sang Woo Joo, Tapas Kumar Mandal

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 207 - 207

Published: Feb. 18, 2025

The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.

Language: Английский

Citations

3
Recent Advancements of Bio-Derived Flame Retardants for Polymeric Materials DOI Open Access
Min Chen, Qingjie Guo, Yao Yuan

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(2), P. 249 - 249

Published: Jan. 20, 2025

The sustainable flame retardancy of polymeric materials is a key focus for the direction next generation in field fire safety. Bio-derived retardants are gaining attention as environmentally friendly additives due to their low ecological impact and decreasing costs. These compounds can enhance char formation by swelling upon heating, attributed functional groups. This review explores various biomolecules used retardants, including phytic acid, chitosan, lignin, tannic bio-derived phosphorus nitrogen compounds, emphasizing flame-retardant properties compatibility with different polymer matrices. primary on structural characteristics, modifications, behaviors these additives, particularly regarding mechanisms action within materials. Finally, opportunities, current challenges, future directions practical application

Language: Английский

Citations

2