Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(40), P. 11829 - 11840
Published: Jan. 1, 2022
Copper
(Cu)
in
its
ionic
forms
is
an
essential
element
for
mammals
and
homeostasis
tightly
controlled.
Accordingly,
Cu-dyshomeostasis
can
be
lethal
as
the
case
well-established
genetic
Wilson's
Menkes
diseases.
In
Alzheimer's
disease
(AD),
Cu-accumulation
occurs
amyloid
plaques,
where
it
bound
to
amyloid-beta
peptide
(Aβ).
vitro,
Cu-Aβ
competent
catalyze
production
of
reactive
oxygen
species
(ROS)
presence
ascorbate
under
aerobic
conditions,
hence
believed
contribute
oxidative
stress
AD.
Several
molecules
that
recover
extracellular
Cu
from
Aβ
transport
back
into
cells
with
beneficial
effects
cell
culture
transgenic
AD
models
were
identified.
However,
all
Cu-shuttles
currently
available
are
not
satisfactory
due
various
potential
limitations
including
ion
selectivity
toxicity.
Hence,
we
designed
a
novel
peptide-based
shuttle
following
properties:
(i)
contains
Cu(ii)-binding
motif
very
selective
Cu(ii)
over
other
metal
ions;
(ii)
tagged
fluorophore
sensitive
release;
(iii)
made
platform,
which
versatile
add
new
functions.
The
work
presented
here
reports
on
characterization
AKH-αR5W4NBD,
able
ions
selectively
PC12
imported
appeared
bioavailable,
likely
via
reductive
release
induced
by
glutathione.
Moreover,
AKH-αR5W4NBD
was
withdraw
Aβ1-16
consequently
inhibited
based
related
could
valuable
tool
Cu-transport
suitable
mechanistic
studies
culture,
applications
restoring
Cu-homeostasis
Cu-related
diseases
such
Molecules,
Journal Year:
2025,
Volume and Issue:
30(2), P. 396 - 396
Published: Jan. 18, 2025
Ratiometric
lanthanide
coordination
polymers
(Ln-CPs)
are
advanced
materials
that
combine
the
unique
optical
properties
of
ions
(e.g.,
Eu3+,
Tb3+,
Ce3+)
with
structural
flexibility
and
tunability
polymers.
These
widely
used
in
biological
chemical
sensing,
environmental
monitoring,
medical
diagnostics
due
to
their
narrow-band
emission,
long
fluorescence
lifetimes,
excellent
resistance
photobleaching.
This
review
focuses
on
composition,
sensing
mechanisms,
applications
ratiometric
Ln-CPs.
The
mechanism
relies
two
distinct
emission
bands,
which
provides
a
self-calibrating,
reliable,
precise
method
for
detection.
relative
intensity
ratio
between
these
bands
varies
concentration
target
analyte,
enabling
real-time
monitoring
minimizing
interference.
approach
is
particularly
suitable
detecting
trace
analytes
use
complex
environments
where
factors
like
background
noise,
temperature
fluctuations,
light
variations
may
affect
results.
Finally,
we
outline
future
research
directions
improving
design
synthesis
Ln-CPs,
such
as
incorporating
long-lifetime
reference
luminescent
molecules,
exploring
near-infrared
systems,
developing
up-conversion
or
two-photon
materials.
Progress
areas
could
significantly
broaden
scope
Ln-CP
applications,
especially
biosensing,
other
fields.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(3), P. 1955 - 1963
Published: Jan. 10, 2023
As
one
of
the
most
typical
bioorthogonal
reactions,
Cu(I)-catalyzed
azide–alkyne
1,3-cycloaddition
(CuAAC)
reaction
has
received
worldwide
attention
in
intracellular
transformation
prodrugs
due
to
its
high
efficiency
and
selectivity.
However,
exogenous
Cu
catalysts
may
disturb
homeostasis
cause
side
effects
normal
tissues.
What
is
more,
intratumoral
Cu(I)
insufficient
efficiently
catalyze
CuAAC
oncogene-induced
labile
deficiency.
Herein,
order
boost
endogenous
level
for
drug
synthesis
through
reaction,
a
self-adaptive
catalysis
system
was
constructed
by
encapsulating
sodium
ascorbate
within
adenosine
triphosphate
aptamer-functionalized
metal–organic
framework
nanoparticles.
The
presents
specificity
tumor
cells
does
not
require
catalysts,
thereby
leading
anti-tumor
efficacy
minimal
both
vitro
vivo.
This
work
will
open
up
new
opportunity
developing
biosafe
high-performance
systems.
Advanced Sensor Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Abstract
Biorecognition
elements
immobilized
into
nanopores
have
transformed
point‐of‐care
(POC)
diagnostics
by
converting
molecular
interactions
electrical
and
fluorescent
signals.This
study
introduces
Bio‐Sensei,
a
high‐throughput
screening
(HTS)
microfluidic
platform
based
on
nanopore
biosensing.
Integrating
robotic
sampler,
electrochemical,
fluorescence
setup,
Bio‐Sensei
operates
as
an
Internet
of
Things
(IoT)
with
integrated
data
analysis.
The
platform's
utility
is
demonstrated
functionalized
amino
terminal
Cu(II)‐
Ni(II)‐binding
(ATCUN)
peptide
ion
track‐etched
membrane.
Automated
testing
atchieves
significantly
higher
F‐stat
value
than
the
critical
treshold,
while
unsupervised
clustering
reveals
optimalnanopores
pore
size.
biosensordemonstrates
remarkable
stability,
selectivity,
sensitivity
detection
limits
10
−6
using
−15
Musing
cyclic
voltammetry
measurements.
Combining
these
methods
enhances
machine
learning
models
for
Cu
2+
concentration
prediction,
achieving
receiver
operating
characteristic
area
under
curve
values
exceeding
95%.
Journal of Alzheimer s Disease,
Journal Year:
2021,
Volume and Issue:
83(1), P. 23 - 41
Published: July 3, 2021
The
cause
of
Alzheimer's
disease
(AD)
is
incompletely
defined.
To
date,
no
mono-causal
treatment
has
so
far
reached
its
primary
clinical
endpoints,
probably
due
to
the
complexity
and
diverse
neuropathology
contributing
neurodegenerative
process.
In
present
paper,
we
describe
plausible
etiological
role
copper
(Cu)
imbalance
in
disease.
Cu
strongly
associated
with
neurodegeneration
dementia,
but
a
complete
biochemical
etiology
consistent
clinical,
chemical,
genetic
data
required
support
causative
association,
rather
than
just
correlation
We
hypothesize
that
aging
human
brain
evolves
as
gradual
shift
from
bound
metal
ion
pools,
both
loss
energy
production
antioxidant
function,
pools
loosely
ions,
involved
gain-of-function
oxidative
stress,
may
be
aggravated
by
chemical
aging.
explain
how
this
mitochondrial
deficits,
depletion
high-energy
demanding
neurons,
protein
misfolding/oligomerization
produce
different
consequences
shaped
severity
risk
factors,
additional
comorbidities,
combinations
other
types
pathology.
should
viewed
integrated
concomitant
aging,
metabolic
abnormalities,
energetic
neuroinflammation,
relation
tau,
prion
proteins,
α-synuclein,
TAR
DNA
binding
protein-43
(TDP-43)
well
systemic
comorbidity.
Specifically,
Amyloid
Hypothesis
intertwined
because
amyloid-β
precursor
(AβPP)/Aβ
are
probable
Cu/Zn
proteins
potential
natural
buffering
(loss
function),
via
pathogenic
Cu-Aβ.
Advanced Materials Technologies,
Journal Year:
2024,
Volume and Issue:
9(21)
Published: July 23, 2024
Abstract
Modern
sensing
technologies
are
highly
required
for
health
monitoring.
In
this
respect,
the
development
of
small‐size,
high‐performance,
and
self‐powered
biosensors
detecting
quantifying
disease
markers
in
biofluids
can
bring
crucial
changes
improvements
to
concept
monitoring
systems.
Clinical
trials
identify
a
wide
range
biomarkers
that
provide
significant
information.
Research
into
novel
functional
materials
with
outstanding
properties
opens
up
new
perspectives
fabricating
new‐generation
biosensors.
Furthermore,
energy
conversion
storage
units
investigated
integrate
them
develop
Electrochemical
methods
very
attractive
applications
biosensor
technology,
both
terms
biomarker
detection
generation.
Here
recent
achievements
research
electrochemical
detect
sweat
saliva
presented.
Potential
efficient
analysis
these
fluids
discussed
light
their
importance
identifying
various
diseases.
The
influence
electrode
on
performance
sensors
is
discussed.
Progress
developing
operating
strategies
systems
also
A
summary
outlook
presented,
mentioning
major
current
issues
be
explored.
