A novel ratiometric BenzoBODIPY-Based fluorescent probe for the detection and imaging of Cysteine in living cells and zebrafish models DOI

Jiangming Fan,

Bin Lin,

Shuqi Tang

et al.

Talanta, Journal Year: 2024, Volume and Issue: 285, P. 127332 - 127332

Published: Dec. 5, 2024

Language: Английский

Aggregation-induced emission materials-based Electrochemiluminescence emitters for sensing applications: Progress, challenges and perspectives DOI
Xuan Wang,

Rongyan Wan,

Yan Tang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 531, P. 216520 - 216520

Published: Feb. 12, 2025

Language: Английский

Citations

2
A novel coumarin-linked tetraphenylethene fluorescent probe for simultaneous sensing of ATP and GSH DOI

Wei Lang,

Zhiwen Wu,

Jing Li

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 412, P. 135772 - 135772

Published: April 7, 2024

Language: Английский

Citations

12
Mitochondria‐Targeted Polyphenol‐Cysteine Nanoparticles Regulating AMPK‐Mediated Mitochondrial Homeostasis for Enhanced Bone Regeneration DOI

Shufan Yu,

Jing Du,

Qun Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 27, 2024

Abstract Mitochondria are the energy source for basal cell functions as well tissue repair and regeneration. Excessive accumulation of reactive oxygen species (ROS) generated by bone injury can cause oxidative stress mitochondrial damage, negatively affecting osteogenic differentiation repair. However, efficient scavenging ROS (mtROS) restoration homeostasis remain challenging. In this study, mitochondria‐targeted polyphenol/amino acid assembled nanoparticles (denoted EC NPs) constructed, which achieve intracellular scavenging, especially mtROS, recover membrane potential, enhance inherent antioxidant system increasing antioxidase activity GSH levels, following re‐establishment redox homeostasis. The NPs promoted AMPK‐mediated biogenesis, thereby providing more differentiation. Furthermore, not only recovered potential stem cells under but also demonstrated ability to directly promote activating cGMP‐PKG signaling pathway. vivo experiments showed that significantly enhanced biogenesis facilitated regeneration with a higher mass mineral density. Thus, multifunctional nanosystem represents promising therapeutic strategy based on regulation.

Language: Английский

Citations

11
A highly selective ratiometric fluorescent probe for cysteine detection DOI
Yali Cui, Zefeng Song, Xiaomeng Guo

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142031 - 142031

Published: March 1, 2025

Language: Английский

Citations

1
Copper-Based Nanomaterials for Image-Guided Cancer Therapy DOI Creative Commons
Haonan Xu,

Zhili Guo,

Mingjie Li

et al.

BIO Integration, Journal Year: 2024, Volume and Issue: 5(1)

Published: Jan. 1, 2024

Abstract Cancer is a significant disease that poses major threat to human health. Image-guided cancer therapy refers series of medical procedures use imaging technology precisely locate and treat cancer. Combining the dual characteristics images functional nanomaterial (NM) drug carriers, various integrated diagnosis treatment probes have been developed for in vivo dynamic monitoring therapeutic effect evaluation drugs based on imaging. Copper (Cu)-based NMs emerged as valuable products nanotechnology due their unique physicochemical properties, which are influenced by factors, such size, shape, surface properties. In field imaging, Cu-based offer combination desirable characteristics, including fluorescence emission, contrast enhancement, radiolabeling stability. These properties form foundation wide range modalities. addition, can be used carrier diagnostic or synergistic multiple modalities realized doping transition metals into heterostructures. become an important basis imaging-guided with NMs. this review we introduce biocompatible image-guided provide overview promising outcomes biomedical research.

Language: Английский

Citations

5
A ratiometric fluorescent probe for cysteine and glutathione differentiation and its application for cysteine detection in foods DOI

Wenhui You,

Shumei Huang, Gang Chen

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1315, P. 138852 - 138852

Published: June 3, 2024

Language: Английский

Citations

4
Nitrogen@Carbon Quantum Dots for Fluorescence Detection of L-alanine, L-methionine and L-cysteine DOI
Xin Chen,

Q. H. Wang,

Tianrong Zhan

et al.

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

Citations

0
A steric hindrance regulated probe with single excitation dual emissions for self-adaptive detection of biothiols and H2S in human urine samples and living cells DOI

Zhan Wang,

Wenbo Shi, Yijun Gong

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Sulfur-containing small molecules, mainly including cysteine (Cys), homocysteine (Hcy), glutathione (GSH), and hydrogen sulfide (H2S), are crucial biomarkers, their levels in different body locations (living cells, tissues, blood, urine, saliva, etc.) inconsistent constantly changing. Therefore, it is highly meaningful challenging to synchronously accurately detect them complex multi-component samples without mutual interference. In this work, we propose a steric hindrance-regulated probe, NBD-2FDCI, with single excitation dual emissions achieve self-adaptive detection of four analytes. This probe was meticulously designed constructed from pKa-tuned 2FDCI fluorophore thiol-specific recognition moiety NBD. Except for 661 nm fluorescence indicating the total biothiols H2S, Cys Hcy could trigger an additional 550 fluorescence. Utilizing distinctive responses, NBD-2FDCI exhibited exclusive linear ranges GSH, Cys/Hcy, H2S avoid high-level component Thus, then applied sulfur compound measurements urine samples, metabolic disorder bladder cancer patients. Moreover, adaptive imaging cells performed results being consistent vitro testing. word, spatial hindrance strategy-guided probes may exhibit broader prospects similar components samples.

Language: Английский

Citations

0
Integration of Ti3C2Tx MXene quantum dots and MnO2 nanosheet as a label-free “OFF-ON” FRET system for highly sensitive and selective glutathione detection DOI

Haiping Yang,

Li Wang, Wenzhi Ren

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112791 - 112791

Published: Jan. 1, 2025

Language: Английский

Citations

0
A Coumarin‐Based Reversible Fluorescent Probe for Quantitative Detection and Monitoring of Cellular Glutathione DOI
Shanshan Wang, Shihua Yu,

Zhigang Liu

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(12)

Published: March 1, 2025

Abstract An “on‐off‐on” reversible fluorescent probe for response to GSH and H 2 O determination was designed synthesized. Considering the important role of in biological system commonly applied recognition groups, C═C bond coumarin dye successfully used as site. This showed fast (within 5 s) high sensitivity (12.6 nM) process. It could be not only quantitative GSH, but also fluorescence imaging cells. In addition, , which repeated at least 3 times. The experimental results proved that modified from recognized with significant results.

Language: Английский

Citations

0