A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose DOI Creative Commons
Yutong Du,

Zili Yang,

Shixiong Kang

et al.

Sensors, Journal Year: 2023, Volume and Issue: 23(7), P. 3685 - 3685

Published: April 2, 2023

This study presents a glucose biosensor based on electrospun core-sheath nanofibers. Two types of film were fabricated using different electrospinning procedures. Film F1 was composed solely nanofibers modified coaxial process. F2 double-layer hybrid through sequential and blending The bottom layer comprised process, in which pure polymethacrylate type A (Eudragit L100) used as the core section water-soluble lignin (WSL) phenol loaded sheath section. top contained oxidase (GOx) gold nanoparticles, distributed throughout polyvinylpyrrolidone K90 (PVP K90) single-fluid investigated process detail. experimental results demonstrated that had higher degradation efficiency β-D-glucose than F1, reaching maximum over 70% after 12 h within concentration range 10-40 mmol/L. is for colorimetric sensing 1-15 solution exhibited color deepened gradually with an increase concentration. Electrospinning flexible creating structures bio-cascade reactions, can provide simple template developing other nanomaterials.

Language: Английский

Multifunctional mesoporous silica nanoparticles for biomedical applications DOI Creative Commons
Bolong Xu, Shanshan Li, Rui Shi

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

Citations

119
An acid-responsive MOF nanomedicine for augmented anti-tumor immunotherapy via a metal ion interference-mediated pyroptotic pathway DOI

Zhenzhen Feng,

Gui Chen,

Min Zhong

et al.

Biomaterials, Journal Year: 2023, Volume and Issue: 302, P. 122333 - 122333

Published: Sept. 16, 2023

Language: Английский

Citations

73
Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers DOI Open Access
Pu Wang, He Lv,

Xianyang Cao

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 921 - 921

Published: Feb. 12, 2023

Electrospun porous nanofibers have gained a lot of interest recently in various fields because their adjustable structure, high specific surface area, and large number active sites, which can further enhance the performance materials. This paper provides an overview common polymers, preparation, applications electrospun nanofibers. Firstly, polymers commonly used to construct structures main pore-forming methods by electrospinning, namely template method phase separation method, are introduced. Secondly, recent air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound wave absorption, flame retardant, heat insulation reviewed. Finally, challenges possible research directions for future study discussed.

Language: Английский

Citations

72
Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections DOI Creative Commons
Yanli Huang, Xufeng Wan, Qiang Su

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 22, 2024

Abstract Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis amplify efficacy sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine copper, ultrasound-activated piezo-hot carriers transfer easily copper polydopamine. It boosts reactive oxygen species production piezoelectrics, facilitates interconversion between Cu2 + Cu promote hydroxyl radical generation via -catalyzed reactions. Finally, elevated cause membrane structure loosening DNA damage. Transcriptomics metabolomics analysis reveal that intracellular overload restricts tricarboxylic acid cycle, promoting cuproptosis-like death. Therefore, polyetherketoneketone scaffold engineered designed shows excellent antibacterial performance ultrasound stimulation promotes angiogenesis osteogenesis on-demand vivo.

Language: Английский

Citations

54
How can Electrospinning Further Service Well for Pharmaceutical Researches? DOI
Deng‐Guang Yu, Jianfeng Zhou

Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 112(11), P. 2719 - 2723

Published: Aug. 27, 2023

Language: Английский

Citations

51
Hydrogen Sulfide Gas Amplified ROS Cascade: FeS@GOx Hybrid Nanozyme Designed for Boosting Tumor Chemodynamic Immunotherapy DOI

Wanying Sun,

Chengyuan Zhu,

Juan Song

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: April 11, 2023

Chemodynamic immunotherapy that utilizes catalysts to produce reactive oxygen species (ROS) for killing tumor cells and arousing antitumor immunity has received considerable attention. However, it is still restricted by low ROS production efficiency insufficient immune activation, due intricate redox homeostasis in the microenvironment (TME). Herein, a metalloprotein-like hybrid nanozyme (FeS@GOx) designed situ growth of (ferrous sulfide, FeS) natural enzyme (glucose oxidase, GOx) amplify cascade boosting chemodynamic immunotherapy. In FeS@GOx, GOx allows conversion endogenous glucose gluconic acid hydrogen peroxide, which provides favorable increasing peroxide subsequent Fenton reaction FeS nanozymes, thus reinforcing production. Notably, sulfide (H2 S) release activated generation-related pH decrease, can suppress activity thioredoxin reductase catalase further inhibit elimination. Thus, FeS@GOx sustainably accumulation perturb intracellular improve therapy trigger robust immunogenic cell death effective combined with checkpoint blockade. This work proposes feasible H2 S amplified strategy employing bioinspired nanozyme, providing novel pathway multi-enzyme-mediated TME modulation precise efficient

Language: Английский

Citations

47
Recent Combinations of Electrospinning with Photocatalytic Technology for Treating Polluted Water DOI Open Access
He Lv, Yanan Liu,

Yubin Bai

et al.

Catalysts, Journal Year: 2023, Volume and Issue: 13(4), P. 758 - 758

Published: April 15, 2023

Dyes, antibiotics, heavy metal ions, and bacteria are important sources of water pollution. How to solve these issues has become a problem in the fields science technology. People have developed variety technologies treat pollutants water. Photocatalytic technology came into being. As simple environmentally friendly treatment technology, it been widely studied by scientific community. Traditional powder photocatalysts cause secondary pollution environment not conducive recycling. Therefore, large specific surface area reusable membrane built electrospinning favorite today’s Nanofiber membranes prepared structures, which can meet needs different occasions. This review summarizes discusses research progress relationship between structure electrospun fiber membranes, their impacts on photocatalytic performance nanofiber membranes. The performance, challenges, future development directions with kinds techniques using photocatalysis pollutants, reviewed.

Language: Английский

Citations

46
Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy DOI
Ji‐Na Hao,

Kaiming Ge,

Guoli Chen

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(22), P. 7707 - 7736

Published: Jan. 1, 2023

This review summarizes the strategies to engineer CDT nanocatalysts based on diverse nanocarriers, especially those with intrinsic therapeutic activities.

Language: Английский

Citations

45
A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century DOI
Jingyu Wang, Wenling Zhao, Zhao Zhang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 17, 2024

Abstract Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing and treating cancer chronic diseases promote growth nanomedicine. However, there are very few analytical descriptive studies regarding trajectory nanomedicine, key research powers, present landscape, focal investigative points, future outlooks. Herein, articles reviews published Science Citation Index Expanded Web Core Collection from first January 2000 to 18th July 2023 analyzed. a bibliometric visualization publication trends, countries/regions, institutions, journals, categories, themes, references, keywords is produced elaborated. Nanomedicine‐related academic output increasing since COVID‐19 pandemic, solidifying uneven global distribution performance. While China leads terms quantity has numerous highly productive USA advantages impact, commercialization, industrial value. Nanomedicine integrates with other disciplines, establishing interdisciplinary platforms, which drug delivery nanoparticles remain points. Current focuses on integrating nanomedicine cell ferroptosis induction immunotherapy. The keyword “burst testing” identifies promising directions, including immunogenic death, chemodynamic therapy, tumor microenvironment, immunotherapy, extracellular vesicles. prospects, major challenges, barriers addressing these directions discussed.

Language: Английский

Citations

39
A Light‐Triggered J‐Aggregation‐Regulated Therapy Conversion: from Photodynamic/Photothermal Therapy to Long‐Lasting Chemodynamic Therapy for Effective Tumor Ablation DOI

Kai Wei,

Yanxin Wu,

Xian Zheng

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(23)

Published: April 5, 2024

Abstract Reactive oxygen species (ROS) have become an effective tool for tumor treatment. The combination of photodynamic therapy (PDT) and chemodynamic (CDT) takes advantage various ROS enhances therapeutic effects. However, the activation CDT usually occurs before PDT, which hinders sustained maintenance hydroxyl radicals (⋅OH) reduces treatment efficiency. Herein, we present a light‐triggered nano‐system based on molecular aggregation regulation converting cancer from PDT/photothermal (PTT) to long‐lasting CDT. ordered J‐aggregation properties cyanine moiety while simultaneously suppressing capabilities copper‐porphyrin moiety. Upon light irradiation, Cu‐PCy JNPs demonstrate strong photothermal Meanwhile, triggers rapid degradation backbone, leading destruction J‐aggregation. As result, is sequentially activated, generation ⋅OH observed up 48 hours, causing potent cellular oxidative stress apoptosis. Due their excellent accumulation, exhibit in vivo ablation through therapy. This work provides new approach effectively prolonging activity ROS‐based

Language: Английский

Citations

39