Communications Chemistry,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Aug. 13, 2024
Abstract
Mitochondrial
dysregulation
plays
a
significant
role
in
the
carcinogenesis.
On
other
hand,
its
destabilization
strongly
represses
viability
and
metastatic
potential
of
cancer
cells.
Photodynamic
photothermal
therapies
(PDT
PTT)
target
mitochondria
effectively,
providing
innovative
non-invasive
anticancer
therapeutic
modalities.
Cyanine
dyes,
with
strong
mitochondrial
selectivity,
show
enhancing
PDT
PTT.
The
limitations
cyanine
dyes
for
PTT
are
discussed,
along
their
applications
combination
therapies,
theranostic
techniques,
optimal
delivery
systems.
Additionally,
novel
approaches
sonodynamic
therapy
using
photoactive
presented,
highlighting
advances
treatment.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(17), P. 16715 - 16730
Published: Aug. 18, 2023
Photodynamic
therapy
(PDT)
still
faces
great
challenges
with
suitable
photosensitizers,
oxygen
supply,
and
reactive
species
(ROS)
accumulation,
especially
in
the
tumor
microenvironment,
feathering
hypoxia,
high
glucose
metabolism.
Herein,
a
carbon
dots
(CDs)-based
bifunctional
nanosystem
(MnZ@Au),
acting
as
photosensitizer
nanozyme
cascading
oxidase
(GOx)-
catalase
(CAT)-like
reactivity,
was
developed
for
improving
hypoxia
regulating
metabolism
to
enhance
PDT.
The
MnZ@Au
constructed
using
Mn-doped
CDs
(Mn-CDs)
core
zeolitic
imidazolate
framework-8
(ZIF-8)
shell
form
hybrid
(MnZ),
followed
by
anchoring
ultrasmall
Au
nanoparticles
(AuNPs)
onto
surface
of
MnZ
through
ion
exchange
situ
reduction
methods.
catalyzed
consumption
generation
GOx-
CAT-like
reactions,
which
further
enhanced
its
own
photothermal
properties.
In
vitro
vivo
studies
also
confirmed
that
greatly
improved
penetration,
promoted
ROS
PDT
efficacy,
leading
efficient
growth
inhibition
breast
model.
Besides,
enabled
photoacoustic
(PA)
imaging
provide
mapping
Mn-CDs
distribution
saturation,
showing
real-time
catalytic
process
vivo.
18F-Fluorodeoxyglucose
positron
emission
tomography
(18F-FDG
PET)
validated
decreased
uptake
tumors
treated
MnZ@Au.
Therefore,
integrated
design
provided
promising
strategy
utilize
regulate
promote
PDT,
finally
prevent
deterioration.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(8), P. 6314 - 6332
Published: Feb. 12, 2024
Immune
checkpoint
blockade
(ICB)
therapy
still
suffers
from
insufficient
immune
response
and
adverse
effect
of
ICB
antibodies.
Chemodynamic
(CDT)
has
been
demonstrated
to
be
an
effective
way
synergize
with
therapy.
However,
a
low
generation
rate
reactive
oxygen
species
poor
tumor
penetration
CDT
platforms
decline
the
effects.
Herein,
charge-reversal
nanohybrid
Met@BF
containing
both
Fe3O4
BaTiO3
nanoparticles
in
core
Metformin
(Met)
on
surface
was
fabricated
for
microenvironment
(TME)-
ultrasound
(US)-activated
piezocatalysis-chemodynamic
immunotherapy
cancer.
Interestingly,
had
negative
charge
blood
circulation,
which
rapidly
changed
into
positive
when
exposed
acidic
TME
attributed
quaternization
tertiary
amine
Met,
facilitating
deep
penetration.
Subsequently,
US
irradiation,
produced
H2O2
based
piezocatalysis
BaTiO3,
greatly
enhanced
Fenton
reaction
Fe3O4,
thus
boosting
robust
antitumor
response.
Furthermore,
PD-L1
expression
inhibited
by
local
released
Met
further
augment
effect,
achieving
inhibitions
primary
metastatic
tumors.
Such
combination
piezocatalysis-enhanced
chemodynamic
Met-mediated
downregulation
provides
promising
strategy
cancer
immunotherapy.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 29, 2024
Thermoelectric
technology
has
recently
emerged
as
a
distinct
therapeutic
modality.
However,
its
effectiveness
is
significantly
limited
by
the
restricted
temperature
gradient
within
living
organisms.
In
this
study,
we
introduce
high-performance
plasmonic-thermoelectric
catalytic
therapy
utilizing
urchin-like
Cu
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Aug. 8, 2024
Although
nanocatalytic
medicine
has
demonstrated
its
advantages
in
tumor
therapy,
the
outcomes
heavily
relie
on
substrate
concentration
and
metabolic
pathways
are
still
indistinct.
We
discover
that
violet
phosphorus
quantum
dots
(VPQDs)
can
catalyze
production
of
reactive
oxygen
species
(ROS)
without
requiring
external
stimuli
catalytic
substrates
confirmed
to
be
(O2)
hydrogen
peroxide
(H2O2)
through
computational
simulation
experiments.
Considering
short
O2
H2O2
at
site,
we
utilize
calcium
(CaO2)
supply
for
VPQDs
construct
nanoparticles
together
with
them,
named
VPCaNPs.
VPCaNPs
induce
oxidative
stress
cells,
particularly
characterized
by
a
significant
increase
hydroxyl
radicals
superoxide
radicals,
which
cause
substantial
damage
structure
function
ultimately
leading
cell
apoptosis.
Intriguingly,
provided
CaO2
degrade
slowly,
degradation
product,
phosphate,
as
well
CaO2-generated
ions,
promote
calcification.
Antitumor
immune
activation
less
metastasis
also
observed
administrated
animals.
In
conclusion,
our
study
unveils
anti-tumor
activity
catalysts
generating
cytotoxic
ROS
products
calcification,
providing
promising
strategy
treating
tumors.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Nanozymes
have
shown
significant
potential
in
cancer
catalytic
therapy
by
strategically
catalyzing
tumor-associated
substances
and
metabolites
into
toxic
reactive
oxygen
species
(ROS)
situ,
thereby
inducing
oxidative
stress
promoting
cell
death.
However,
within
the
complex
tumor
microenvironment
(TME),
rational
design
of
nanozymes
factors
like
activity,
reaction
substrates,
TME
itself
significantly
influence
efficiency
ROS
generation.
To
address
these
limitations,
recent
research
has
focused
on
exploring
that
affect
activity
developing
nanozyme-based
cascade
systems,
which
can
trigger
two
or
more
processes
tumors,
producing
therapeutic
achieving
efficient
stable
with
minimal
side
effects.
This
area
remarkable
progress.
Perspective
provides
a
comprehensive
overview
nanozymes,
covering
their
classification
fundamentals.
The
regulation
nanozyme
strategies
are
discussed
detail.
Furthermore,
representative
paradigms
for
successful
construction
systems
treatment
summarized
focus
revealing
underlying
mechanisms.
Finally,
we
current
challenges
future
prospects
development
biomedical
applications.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Metastasis,
the
leading
cause
of
mortality
in
cancer
patients,
presents
challenges
for
conventional
photodynamic
therapy
(PDT)
due
to
its
reliance
on
localized
light
and
oxygen
application
tumors.
To
overcome
these
limitations,
a
self‐sustained
organelle‐mimicking
nanoreactor
is
developed
here
with
programmable
DNA
switches
that
enables
bio‐chem‐photocatalytic
cascade‐driven
starvation‐photodynamic
synergistic
against
tumor
metastasis.
Emulating
compartmentalization
positional
assembly
strategies
found
living
cells,
this
nano‐organelle
reactor
allows
quantitative
co‐compartmentalization
multiple
functional
modules
designed
self‐illuminating
chemiexcited
PDT
system.
Within
space‐confined
nanoreactor,
biofuel
glucose
converted
hydrogen
peroxide
(H
2
O
)
which
enhances
luminol‐based
chemiluminescence
(CL),
consequently
driving
generation
photochemical
singlet
(
1
via
resonance
energy
transfer.
Meanwhile,
hemoglobin
functions
as
synchronized
supplier
both
oxidation
PDT,
while
also
exhibiting
peroxidase‐like
activity
produce
hydroxyl
radicals
(·OH).
Crucially,
keeps
switching
off
normal
tissues,
on‐demand
activation
tumors
through
toehold‐mediated
strand
displacement.
These
findings
demonstrate
self‐sufficient
precise
striking
tumors,
promising
paradigm
managing
highly
metastatic
cancers.
Small,
Journal Year:
2023,
Volume and Issue:
19(45)
Published: July 7, 2023
Abstract
Glioblastoma
is
one
of
the
most
aggressive
central
nervous
system
malignancies
with
high
morbidity
and
mortality.
Current
clinical
approaches,
including
surgical
resection,
radiotherapy,
chemotherapy,
are
limited
by
difficulty
targeting
brain
lesions
accurately,
leading
to
disease
recurrence
fatal
outcomes.
The
lack
effective
treatments
has
prompted
researchers
continuously
explore
novel
therapeutic
strategies.
In
recent
years,
nanomedicine
made
remarkable
progress
expanded
its
application
in
drug
delivery,
providing
a
new
treatment
for
tumors.
Against
this
background,
article
reviews
delivery
systems
paper,
mechanism
nanomaterials
crossing
blood‐brain
barrier
summarized.
Furthermore,
specific
nanotechnology
glioblastoma
discussed
depth.
