Metalation of metal–organic frameworks: fundamentals and applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5626 - 5676

Published: Jan. 1, 2024

Metalation of metal-organic frameworks (MOFs) has been developed as a prominent strategy for materials functionalization pore chemistry modulation and property optimization. By introducing exotic metal ions/complexes/nanoparticles onto/into the parent framework, many metallized MOFs have exhibited significantly improved performance in wide range applications. In this review, we focus on research progress metalation during last five years, spanning design principles, synthetic strategies, potential Based crystal engineering minor change MOF composition through would lead to leveraged variation properties. This review starts from general strategies established incorporation species within MOFs, followed by principles graft desired functionality while maintaining porosity frameworks. Facile contributed great number bespoke with excellent performance, summarize their applications gas adsorption separation, heterogeneous catalysis, detection sensing, energy storage conversion. The underlying mechanisms are also investigated state-of-the-art techniques analyzed gaining insight into structure-property relationships, which turn facilitate further development principles. Finally, current challenges opportunities discussed, promising future directions customizing next-generation advanced outlined well.

Language: Английский

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Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12049 - 12095

Published: May 2, 2024

Cancer, as one of the leading causes death worldwide, drives advancement cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge promising therapeutic nanodrugs that provide a reference therapy. In this review, we present recent breakthrough First, comprehensively outline preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal chemical reduction biomimetic mineralization and sol–gel method. Subsequently, elucidate catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like oxidase (OXD)-like activities) superoxide dismutase (SOD)-like along with their activity regulation such morphology control, size manipulation, modulation, composition adjustment surface modification under environmental stimulation. Furthermore, elaborate on diverse applications anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic (PDT), photothermal (PTT), sonodynamic (SDT), immunotherapy, synergistic Finally, challenges faced by are discussed alongside future research directions. The purpose review is to offer scientific guidance will enhance clinical based transition metals.

Language: Английский

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Tumor microenvironment triggered iron-based metal organic frameworks for magnetic resonance imaging and photodynamic-enhanced ferroptosis therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 382 - 395

Published: Jan. 17, 2025

Language: Английский

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Dual Targeting Biomimetic Carrier‐Free Nanosystems for Photo‐Chemotherapy of Rheumatoid Arthritis via Macrophage Apoptosis and Re‐Polarization

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease that often results in irreversible joint erosion and disability. Methotrexate (MTX) the first-line drug against RA, but significant side effects of long-term administration limit its use. Therefore, new therapeutic strategies are needed for treating RA. Here, dual-targeting biomimetic carrier-free nanomaterials (BSA-MTX-CyI nanosystem, BMC) developed synergistic photo-chemotherapy Bovine serum albumin (BSA), which has high affinity with SPARC (secreted protein acidic rich cysteine) RA microenvironment, selected as hydrophilic end coupled MTX phototherapeutic agent CyI to self-assemble into BMC. In vitro vivo experiments revealed BMC accumulated significantly at site collagen antibody-induced mice could be specifically recognized taken up by folate receptors proinflammatory M1 macrophages. Upon near-infrared laser irradiation, exerted photodynamic photothermal effects, whereas not only inhibited cell proliferation also increased sensitivity reactive oxygen species, enhancing apoptotic effect induced achieving photo-chemotherapy. Moreover, induce macrophages reprogram anti-inflammatory M2 This study provides innovative approaches treatment via macrophage apoptosis re-polarization.

Language: Английский

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Nanozyme-Based Cancer Nanotheranostics: Emerging Applications and Challenges in Brain Cancer Therapeutics

Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4

Published: Jan. 31, 2025

Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.

Language: Английский

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Nanozyme-enhanced ferroptosis for cancer treatment

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(7), P. 1685 - 1702

Published: Jan. 1, 2024

Nanozymes could mimic the catalytic activity of natural enzymes, then stimulate Fenton reaction for reactive oxygen species overproduction and lipid peroxidation, ultimately induce ferroptosis to exert anticancer effects.

Language: Английский

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MOFs‐Based Magnetic Nanozyme to Boost Cascade ROS Accumulation for Augmented Tumor Ferroptosis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: March 26, 2024

The emerging cell death modality of ferroptosis has garnered increasing attention for antitumor treatment but still suffers from low therapeutic efficacy. A metal-organic frameworks (MOFs)-based magnetic nanozyme (PZFH) comprising porphyrin-based Zr-MOF (PCN) on zinc ferrite (ZF) nanoparticles modified with hyaluronic acid, delivering excellent magnetophotonic response efficient ferroptosis, is reported here. PZFH shows multienzyme-like cascade activity encompassing a photon-triggered oxidase-like catalysis to generate O

Language: Английский

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Versatile Nanomaterials That Interfere with Ferroptosis in the Tumor Microenvironment

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2461 - 2473

Published: Feb. 1, 2025

Ferroptosis is a type of iron-dependent programmed cell death characterized by depletion glutathione. Although generally less harmful to normal cells, in tumor the high demand for iron ions provides conditions conducive ferroptosis. In this review, we provide an overview recent progress research on regulation ferroptosis summarizing and assessing current state, trends, applications nanomaterials cells. Given advantages terms targeting, safety, improved drug efficacy, reduced side effects, these materials are considered have potential therapeutic value modulating cells via different mechanisms. respect, describe methods modifying interfering with glutathione activity lipid peroxidation. The development that can be applied induce or inhibit anticipated new options treatment diverse range diseases.

Language: Английский

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Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(11), P. 109562 - 109562

Published: Jan. 26, 2024

Language: Английский

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Stimuli‐Responsive New Horizons for Biomedical Applications: Metal–Organic Framework‐Based Nanozymes

Small Structures, Journal Year: 2024, Volume and Issue: 5(7)

Published: April 26, 2024

Nanozymes, nanomaterials exhibiting enzyme‐mimicking activities, have gained considerable interest in biomedicine due to their stability, adjustability, and cost‐efficiency. Among these, metal–organic framework (MOF)‐based nanozymes distinguish themselves by distinct structure customizable characteristics. Researchers explored MOF‐based as a platform for developing stimuli‐responsive behaviors. This work first presents the categorization of nanozymes, which are designed mimic catalytic functions oxidases, peroxidases, catalase, superoxide dismutase, hydrolases, multifunctional enzymes. Crafting includes customizing reactions particular stimuli, including pH, temperature, light, or biomolecular triggers, ensuring enhanced specificity potency performance amid environmental changes. Moreover, these exhibit immense potential biomedical applications, playing crucial roles therapeutic interventions like cancer therapy tissue regeneration. Finally, article delves into future opportunities challenges within emerging research frontiers. These offer novel avenues advanced strategies, providing prospects innovative applications.

Language: Английский

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