Luminescence,
Journal Year:
2024,
Volume and Issue:
39(9)
Published: Sept. 1, 2024
Abstract
Near‐infrared
(NIR)
fluorescent
probes
with
aggregation‐induced
emission
(AIE)
properties
are
of
great
significance
in
cell
imaging
and
cancer
therapy.
However,
the
complexity
its
synthesis,
poor
photostabilities,
expensive
raw
materials
still
pose
some
obstacles
to
their
practical
application.
This
study
reported
an
AIE
luminescent
material
red
application
vitro
photodynamic
therapy
(PDT)
study.
has
characteristics
simple
large
Stokes
shift,
good
excellent
lipid
droplets‐specific
testing
ability.
Interestingly,
this
red‐emitting
can
effectively
produce
reactive
oxygen
species
(ROS)
under
white
light
irradiation,
further
achieving
PDT‐mediated
killing
cells.
In
conclusion,
demonstrates
a
approach
synthesize
NIR
both
therapeutic
effects,
providing
ideal
architecture
for
constructing
long‐wavelength
materials.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(21), P. 8356 - 8364
Published: May 16, 2024
Lipids
are
essential
for
various
cellular
functions,
including
energy
storage,
membrane
flexibility,
and
signaling
molecule
production.
Maintaining
proper
lipid
levels
is
important
to
prevent
health
problems
such
as
cancer,
neurodegenerative
disorders,
cardiovascular
diseases,
obesity,
diabetes.
Monitoring
droplets
(LDs)
in
real-time
with
high
resolution
can
provide
insights
into
LD-related
pathways
diseases
owing
the
dynamic
nature
of
LDs.
Fluorescence-based
imaging
widely
used
tracking
LDs
live
cells
animal
models.
However,
current
fluorophores
have
limitations
poor
photostability
background
staining.
Herein,
we
developed
a
novel
fluorogenic
probe
based
on
push–pull
interaction
combined
aggregation-induced
emission
enhancement
(AIEE)
Probe
1
exhibits
favorable
permeability
spectroscopic
characteristics,
allowing
specific
time-lapse
LD
accumulation.
This
also
be
examine
fruit
fly
tissues
metabolic
states,
serving
highly
versatile
tool
tissue
environments.
