FRET-Based Nanoprobe with Adaptive Background Suppression for Reliable Detection of ONOO–/ClO– in Whole Blood: Facilitating Monitoring of Sepsis Progression and Hemolytic Disorders DOI

Zhiyang Yuwen,

Tenglong Zou,

Zili He

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abnormal fluctuations in blood biomarker levels serve as critical indicators of the disease. However, detecting endogenous substances whole using fluorescent probes is challenging due to its complex composition. This challenge primarily arises from two factors: high autofluorescence and intrinsic fluorescence probe, both contributing significant background detection system. To overcome these obstacles, we introduced a donor–acceptor "one-to-many" FRET-based sensing strategy integrated with suppression design multifunctional nanoprobe. The donor effectively suppresses through inner filter effect efficiently quenches by adjusting acceptor-to-donor ratio, achieving "zero" detection. Leveraging this excellent quenching effect, successfully detected ONOO– ClO– samples mice sepsis or hemolytic diseases. Furthermore, monitored changes throughout disease course, revealing positive correlation between concentrations severity. innovative for provides valuable insights designing directly detect blood.

Language: Английский

Recent advances in centrifugal microfluidics for point-of-care testing DOI
Huijuan Yuan,

Zeyu Miao,

Chao Wan

et al.

Lab on a Chip, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Centrifugal microfluidics, with its advantages of rapid and precise fluid control without the need for external pressure, is widely applied in point-of-care testing.

Language: Английский

Citations

3
Nanoprobes based on optical imaging techniques for detecting biomarkers in liver injury diseases DOI

Ye Sun,

Jing Wang, Yanyan Zhu

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 524, P. 216303 - 216303

Published: Nov. 10, 2024

Language: Английский

Citations

6
GSH-responsive nanomedicine for disease smart imaging and therapy DOI

Zi Fu,

Di Zhou, Zeyang Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216554 - 216554

Published: Feb. 27, 2025

Language: Английский

Citations

0
Self-assembled nanoprobes for cancer phototheranostics DOI
Sondavid Nandanwar,

Van Kieu Thuy Nguyen,

Dai Lam Tran

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216643 - 216643

Published: April 18, 2025

Language: Английский

Citations

0
Advanced Nanoprobe Strategies for Imaging Macrophage Polarization in Cancer Immunology DOI Creative Commons
Junjie Zhang,

Kaiyuan Tang,

Yongbin Yang

et al.

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Macrophages are ubiquitous within the human body and serve pivotal roles in immune surveillance, inflammation, tissue homeostasis. Phenotypic plasticity is a hallmark of macrophages, allowing their polarization into distinct phenotypes M1 (pro-inflammatory, anti-tumor) M2 (anti-inflammatory, pro-tumor) response to local microenvironmental cues. In tumor tissues, tumor-associated macrophages profoundly shapes microenvironment, influencing progression, evasion, metastasis. Therefore, ability image monitor macrophage essential for comprehending biology optimizing therapeutic strategies. With rapid advancement nanomedicine, diverse array nanoprobes has been engineered specifically target offering new avenues noninvasive vivo imaging real-time monitoring dynamics microenvironment. This perspective highlights recent advancements macrophage-targeting both vitro vivo. It also addresses current challenges field, such as enhancing probe sensitivity, specificity, biocompatibility, while outlining future directions development next-generation aimed at precision oncology.

Language: Английский

Citations

0
Novel phenothiazine appended thiophene and pyridine for highly selective and sensitive detection of hypochlorite in aqueous and living cells. DOI
Vinayagam Dhandapani, S. Karpagam

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139227 - 139227

Published: July 10, 2024

Language: Английский

Citations

2
Multichannel Lanthanide‐Doped Nanoprobes for Serodiagnosis and Therapy DOI Creative Commons
Yuxin Liu, Wei Zheng

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Abstract In this account, we will highlight recent progress in the development of multichannel lanthanide‐doped (MC−Ln) nanoprobes for highly efficient serodiagnosis and therapy, with a particular focus on our own work. First, first provide classification types MC−Ln based contained type number signals. The merits different reason using lanthanides are elucidated. Then, an overview current uses focusing strategic exploration to improve diagnostic therapeutic performance from perspectives. Finally, present prospective outlook future potential issues next‐generation nanoprobes. We hope that timely account update understanding similar bioapplications helpful references state‐of‐the‐art tools therapy.

Language: Английский

Citations

2
FRET-Based Nanoprobe with Adaptive Background Suppression for Reliable Detection of ONOO–/ClO– in Whole Blood: Facilitating Monitoring of Sepsis Progression and Hemolytic Disorders DOI

Zhiyang Yuwen,

Tenglong Zou,

Zili He

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abnormal fluctuations in blood biomarker levels serve as critical indicators of the disease. However, detecting endogenous substances whole using fluorescent probes is challenging due to its complex composition. This challenge primarily arises from two factors: high autofluorescence and intrinsic fluorescence probe, both contributing significant background detection system. To overcome these obstacles, we introduced a donor–acceptor "one-to-many" FRET-based sensing strategy integrated with suppression design multifunctional nanoprobe. The donor effectively suppresses through inner filter effect efficiently quenches by adjusting acceptor-to-donor ratio, achieving "zero" detection. Leveraging this excellent quenching effect, successfully detected ONOO– ClO– samples mice sepsis or hemolytic diseases. Furthermore, monitored changes throughout disease course, revealing positive correlation between concentrations severity. innovative for provides valuable insights designing directly detect blood.

Language: Английский

Citations

1