Substituent‐Modulated Excited Triplet States and Activities of Ruthenium Complexes for Dual Photodynamic/Sonodynamic Therapy to Cisplatin‐Resistant Non‐Small Cell Lung Cancer DOI

Dan-Dan Xie,

Xuelian Li,

Lizhen Zeng

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Six polypyridyl Ru(II) complexes were designed for single-molecule photodynamic and sonodynamic therapy (PDT/SDT) synergistic multimodal anticancer toward cisplatin-resistant NSCLC. They demonstrated lowest 3ES with distinct intraligand transition nature, which is beneficial singlet oxygen generation. Remarkable quantum yields of both superoxide anion under either 808 nm laser irradiation or ultrasonic treatment could induce apoptosis ferroptosis A549R cells. Cytotoxicity experiments clearly a effect between PDT SDT. The relationship the structures these their cellular biological mechanisms has been explored in detail. Using sensitizer to achieve PDT/SDT may provide valuable insights drug-resistant tumors that located deeply hypoxic microenvironment.

Language: Английский

Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemoresistant Cancer DOI

Lizhen Zeng,

Xue‐Lian Li,

Yu‐Ang Deng

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

A series of dinuclear Ir(III) complexes have been constructed for enhanced photodynamic and photothermal therapy (PDT PTT) cisplatin-resistant non-small-cell lung cancer. They enter cells via caveolar endocytosis, target mitochondria but not nuclear, generate both singlet oxygen superoxide anion, release heat when exposed to infrared (IR) irradiation, thus inducing reactive species (ROS)-associated cell disruption thermal ablation. The IR-generated ROS can further activate caspases, triggering apoptosis. Additionally, the deplete intracellular glutathione, lead lipid peroxidation, induce ferroptosis. selected complex

Language: Английский

Citations

4
Chemiluminescent transition metal complexes: Mechanisms and applications DOI
Jinghui Zhu,

Mingrui Gu,

Yahui Chen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216495 - 216495

Published: Feb. 5, 2025

Language: Английский

Citations

2
A Highly Bright Red-light Chemiluminescent Probe for Inflammation Imaging DOI

Haijun Ning,

Yuxin Yang,

Saran Long

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112780 - 112780

Published: March 1, 2025

Language: Английский

Citations

1
BODIPY based nanomedicine for cancer imaging and phototherapy DOI Creative Commons
Dapeng Chen, Tian Zhang, Xiaochen Dong

et al.

Colloids and Interface Science Communications, Journal Year: 2024, Volume and Issue: 64, P. 100816 - 100816

Published: Dec. 28, 2024

Language: Английский

Citations

3
Subcellular organelle targeted tumor phototherapy DOI
Man Lu,

Mingjing Huang,

Jing Chen

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216635 - 216635

Published: March 26, 2025

Language: Английский

Citations

0
Molecular Strategies for Constructing Epoxy‐Type Afterglow Probes in Disease Diagnosis and Treatment DOI

Maocheng Zuo,

Yidan Hu,

L. Xiao

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Epoxy‐type afterglow luminescence is a cascade reaction of photochemical defects caused as result the formation and release epoxy intermediates, exhibiting continuous phenomenon that remains intrinsic after excitation, with extremely impressive signal‐to‐background ratio (SBR) level in vivo. Afterglow based on this epoxy‐type mechanism ideally suited for applications developments diagnosis treatment biological diseases. In tutorial review, work aims to deeply elaborate mechanisms materials present application imaging Lastly, future perspectives potential challenges technology preclinical diagnostic, therapeutic, predictive analyses, well clinical translations are discussed.

Language: Английский

Citations

0
Dinuclear Ru(II) Complexes for Synergetic Photodynamic, Photothermal, and Sonodynamic Therapy against Cisplatin-Resistant Cancer DOI
Xiaoxia Ren, Xuelian Li, Runyu Zhao

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

A new series of dinuclear Ru(II) complexes with a novel bridging ligand were developed for the treatment cisplatin-resistant non-small-cell lung cancer via synergistic photodynamic, photothermal, and sonodynamic therapy mechanism. Comprehensive experimental theoretical studies investigated their photophysical photochemical properties along influence ancillary ligands. The exhibit significant two-photon absorption at IR region, facilitating ROS generation through both type I II mechanisms under laser ultrasound exposure. They effectively target mitochondria nuclei, regulating DNA-related mechanisms, including inhibition DNA topoisomerase RNA polymerase while promoting photoactivated apoptosis ferroptosis. high synergy effect between was attributed to rise in oxygen availability ultrasound-induced cavitation thermal-induced increase vascular permeability partial pressure. In vivo experiments confirmed that combination yielded superior therapeutic outcomes compared single-modality treatments. tested complex exhibited excellent safety rapid clearance low toxicity normal cells. These findings suggest IR-activated metal can significantly advance integrated diagnostic approaches, overcoming challenges such as drug resistance hypoxic environments deep tumors.

Language: Английский

Citations

0
Type I BODITh Photosensitizers with Twisted Conformation for Augmented Photodynamic Therapy and FOXO1-Involved Apoptosis DOI
Tian Zhang, Jiahong Li, Jinjun Shao

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Developing targeted type I photosensitizers with low oxygen-dependence is essential to overcome tumor hypoxia and address the short diffusion radius of free radicals in photodynamic therapy (PDT). Herein, two Boron dithiazolemethene (BODITh)-derivatives, SBDP-1 SBDP-2 different numbers thiophene units, were designed as mitochondria-targeted significant ·OH generation. Through theoretical calculations, additional unit induced a torsional conformation smaller overlap integral holes electrons than SBDP-1, resulting an increased spin-orbit coupling (SOC) constant decreased singlet-triplet energy gap (ΔEST), thereby promoting intersystem crossing (ISC) process. Moreover, through molecular docking study, NPs could bind miR-96 via hydrophobic interaction trigger forkhead box protein O1 (FOXO1) involved pathway accelerate cell apoptosis. This work presented innovative twisted for efficient cancer PDT conquer hypoxia.

Language: Английский

Citations

0
Substituent‐Modulated Excited Triplet States and Activities of Ruthenium Complexes for Dual Photodynamic/Sonodynamic Therapy to Cisplatin‐Resistant Non‐Small Cell Lung Cancer DOI

Dan-Dan Xie,

Xuelian Li,

Lizhen Zeng

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Six polypyridyl Ru(II) complexes were designed for single-molecule photodynamic and sonodynamic therapy (PDT/SDT) synergistic multimodal anticancer toward cisplatin-resistant NSCLC. They demonstrated lowest 3ES with distinct intraligand transition nature, which is beneficial singlet oxygen generation. Remarkable quantum yields of both superoxide anion under either 808 nm laser irradiation or ultrasonic treatment could induce apoptosis ferroptosis A549R cells. Cytotoxicity experiments clearly a effect between PDT SDT. The relationship the structures these their cellular biological mechanisms has been explored in detail. Using sensitizer to achieve PDT/SDT may provide valuable insights drug-resistant tumors that located deeply hypoxic microenvironment.

Language: Английский

Citations

2