Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(51)
Published: May 5, 2023
Abstract
Recently,
2D
transition
metal
carbide,
nitride,
and
carbonitrides
(MXenes)
materials
stand
out
in
the
field
of
tumor
therapy,
particularly
construction
functional
platforms
for
optimal
antitumor
therapy
due
to
their
high
specific
surface
area,
tunable
performance,
strong
absorption
near‐infrared
light
as
well
preferable
plasmon
resonance
effect.
In
this
review,
progress
MXene‐mediated
is
summarized
after
appropriate
modifications
or
integration
procedures.
The
enhanced
treatments
directly
performed
by
MXenes,
significant
improving
effect
MXenes
on
different
therapies,
imaging‐guided
strategies
are
discussed
detail.
Moreover,
existing
challenges
future
development
directions
presented.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(2), P. 1111 - 1137
Published: Nov. 27, 2020
This
review
summarizes
the
recent
development
of
second
near-infrared
photothermal
combinational
nanotheranostics
for
cancer,
infectious
diseases
and
regenerative
medicine.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(15), P. 8669 - 8742
Published: Jan. 1, 2021
Inorganic
nanomaterials
that
have
inherently
exceptional
physicochemical
properties
(e.g.,
catalytic,
optical,
thermal,
electrical,
or
magnetic
performance)
can
provide
desirable
functionality
drug
delivery,
diagnostics,
imaging,
therapy)
considerable
potential
for
application
in
the
field
of
biomedicine.
However,
toxicity
be
caused
by
long-term,
non-specific
accumulation
these
inorganic
healthy
tissues,
preventing
their
large-scale
clinical
utilization.
Over
past
several
decades,
emergence
biodegradable
and
clearable
has
offered
to
prevent
such
long-term
toxicity.
In
addition,
a
comprehensive
understanding
design
metabolic
pathways
within
body
is
essential
enabling
expansion
theranostic
applications
various
diseases
advancing
trials.
Thus,
it
critical
importance
develop
biomedical
applications.
This
review
systematically
summarizes
recent
progress
nanomaterials,
particularly
cancer
theranostics
other
disease
therapies.
The
future
prospects
opportunities
this
rapidly
growing
are
also
discussed.
We
believe
timely
will
stimulate
guide
additional
in-depth
studies
area
nanomedicine,
as
rapid
vivo
clearance
degradation
likely
prerequisite
translation
with
unique
functionality.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(12), P. 4996 - 5041
Published: Jan. 1, 2022
This
review
systematically
summarizes
the
research
status,
challenges,
prospects,
and
potential
bench-to-bedside
translation
of
minimally
invasive
nanomedicines.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(13)
Published: March 1, 2021
Abstract
Nanotheranostic
agents
of
gold
nanomaterials
in
the
second
near‐infrared
(NIR‐II)
window
have
attracted
significant
attention
cancer
management,
owing
to
reduced
background
signal
and
deeper
penetration
depth
tissues.
However,
it
is
still
challenging
modulate
localized
surface
plasmon
resonance
(LSPR)
from
first
(NIR‐I)
NIR‐II
region.
Herein,
a
plasmonic
modulation
strategy
nanorods
(GNRs)
through
manganese
dioxide
coating
developed
for
photoacoustic/magnetic
(MR)
duplex‐imaging‐guided
photothermal
chemodynamic
therapy.
GNRs
are
coated
with
silica
(SiO
2
)
then
covered
magnesium
(MnO
obtain
final
product
GNR@SiO
@MnO
(denoted
as
GSM).
The
LSPR
peak
could
be
tuned
by
adjusting
thickness
MnO
layer.
Theoretical
simulations
reveal
that
this
mainly
due
change
refraction
index
around
after
Additionally,
layer
demonstrated
degrade
into
Mn
2+
ions
response
peroxide
acidic
protons
tumor
microenvironment,
which
allows
MR
imaging
This
can
adapted
other
metal
construction
new
class
nanotheranostics.
Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(20), P. 11381 - 11485
Published: Jan. 1, 2021
To
date,
nanotechnology
has
increasingly
been
identified
as
a
promising
and
efficient
means
to
address
number
of
challenges
associated
with
public
health.
In
the
past
decade,
two-dimensional
(2D)
biomaterials,
unique
nanoplatform
planar
topology,
have
attracted
explosive
interest
in
various
fields
such
biomedicine
due
their
morphology,
physicochemical
properties
biological
effect.
Motivated
by
progress
graphene
biomedicine,
dozens
types
ultrathin
2D
biomaterials
found
versatile
bio-applications,
including
biosensing,
biomedical
imaging,
delivery
therapeutic
agents,
cancer
theranostics,
tissue
engineering,
well
others.
The
effective
utilization
stems
from
in-depth
knowledge
structure-property-bioactivity-biosafety-application-performance
relationships.
A
comprehensive
summary
for
is
still
lacking.
this
review,
we
aim
concentrate
on
state-of-the-art
particular
focus
applications.
particular,
discuss
design,
fabrication
functionalization
used
diverse
applications
based
up-to-date
progress.
Furthermore,
interactions
between
systems
spatial-temporal
scale
are
highlighted,
which
will
deepen
understanding
underlying
action
mechanism
aiding
design
improved
functionalities.
Finally,
taking
bench-to-bedside
focus,
conclude
review
proposing
current
crucial
issues/challenges
presenting
future
development
directions
advance
clinical
translation
these
emerging
biomaterials.
BioMedical Engineering OnLine,
Journal Year:
2021,
Volume and Issue:
20(1)
Published: April 1, 2021
Abstract
MXene
is
a
recently
emerged
multifaceted
two-dimensional
(2D)
material
that
made
up
of
surface-modified
carbide,
providing
its
flexibility
and
variable
composition.
They
consist
layers
early
transition
metals
(M),
interleaved
with
n
carbon
or
nitrogen
(denoted
as
X)
terminated
surface
functional
groups
T
x
/T
z
)
general
formula
M
n+1
X
,
where
=
1–3.
In
general,
MXenes
possess
an
exclusive
combination
properties,
which
include,
high
electrical
conductivity,
good
mechanical
stability,
excellent
optical
properties.
also
exhibit
biological
area
for
drug
loading/delivery,
hydrophilicity
biocompatibility,
other
electronic-related
properties
computed
tomography
(CT)
scans
magnetic
resonance
imaging
(MRI).
Due
to
the
attractive
physicochemical
biocompatibility
novel
2D
materials
have
enticed
uprising
research
interest
application
in
biomedicine
biotechnology.
Although
some
potential
applications
been
explored
recently,
types
applied
perspective
biomedical
engineering
are
limited
few,
titanium
carbide
tantalum
families
MXenes.
This
review
paper
aims
provide
overview
structural
organization
MXenes,
different
top-down
bottom-up
approaches
synthesis
whether
they
fluorine-based
fluorine-free
etching
methods
produce
biocompatible
can
be
further
modified
enhance
biodegradability
reduce
cytotoxicity
biosensing,
cancer
theranostics,
delivery
bio-imaging
applications.
The
antimicrobial
activity
mechanism
damaging
cell
membrane
were
discussed.
Some
challenges
vivo
applications,
pitfalls,
future
outlooks
deployment
devices
demystified.
Overall,
this
puts
into
current
advancements
prospects
realizing
nanomaterial
versatile
tool.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(16), P. 14290 - 14320
Published: April 10, 2023
Cancer
is
ranked
as
the
second
leading
cause
of
death
globally.
Traditional
cancer
therapies
including
chemotherapy
are
flawed,
with
off-target
and
on-target
toxicities
on
normal
cells,
requiring
newer
strategies
to
improve
cell
selective
targeting.
The
application
nanomaterial
has
been
extensively
studied
explored
chemical
biology
tools
in
theranostics.
It
shows
greater
applications
toward
stability,
biocompatibility,
increased
permeability,
resulting
precise
targeting,
mitigating
shortcomings
traditional
therapies.
nanoplatform
offers
an
exciting
opportunity
gain
targeting
multifunctionality.
advent
nanotechnology,
particular
development
smart
nanomaterials,
transformed
diagnosis
treatment.
large
surface
area
nanoparticles
enough
encapsulate
many
molecules
ability
functionalize
various
biosubstrates
such
DNA,
RNA,
aptamers,
antibodies,
which
helps
theranostic
action.
Comparatively,
biologically
derived
nanomaterials
perceive
advantages
over
produced
by
conventional
methods
terms
economy,
ease
production,
reduced
toxicity.
present
review
summarizes
techniques
theranostics
emphasizes
(such
organic
(NPs),
inorganic
NPs,
carbon-based
NPs).
We
also
critically
discussed
challenges
impeding
their
translation
treatment
diagnostic
applications.
This
concludes
that
use
could
significantly
will
facilitate
new
dimensions
for
tumor
detection
therapy.
