Nanotechnology meets glioblastoma multiforme: Emerging therapeutic strategies DOI
Dongdong Liu, Xingliang Dai,

Lei Ye

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Aug. 12, 2022

Glioblastoma multiforme (GBM) represents the most common and fatal form of primary invasive brain tumors as it affects a great number patients each year has median overall survival approximately 14.6 months after diagnosis. Despite intensive treatment, almost all with GBM experience recurrence, their 5-year rate is 5%. At present, main clinical treatment strategy includes surgical resection, radiotherapy, chemotherapy. However, tumor heterogeneity, blood-brain barrier, glioma stem cells, DNA damage repair mechanisms hinder efficient treatment. The emergence nanometer-scale diagnostic therapeutic approaches in cancer medicine due to establishment nanotechnology provides novel promising tools that will allow us overcome these difficulties. This review summarizes application recent progress nanotechnology-based monotherapies (e.g., chemotherapy) combination strategies (chemotherapy-based combined therapy) for describes synergistic enhancement between therapies well current standard therapy its deficiencies. These can reduce individual drug-related toxicities significantly enhance efficiency have recently undergone rapid development. underlying different photodynamic chemodynamic been systematically summarized here an attempt developments identify directions future research. clinically significant insights GBM, which importance. article categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Diagnostic Tools In Vivo Nanodiagnostics Imaging.

Language: Английский

Ultrasound-Augmented Multienzyme-like Nanozyme Hydrogel Spray for Promoting Diabetic Wound Healing DOI
Limin Shang, Yixin Yu, Yujie Jiang

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15962 - 15977

Published: Aug. 3, 2023

Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic carbon nitride nanosheets (ACPCAH). This possesses five types enzyme-like activities, including superoxide dismutase (SOD)-, catalase (CAT)-, glucose oxidase (GOx)-, peroxidase (POD)-, nitric oxide synthase (NOS)-like activities. The kinetics reaction mechanism sonodynamic/sonothermal synergistic enhancement SOD-CAT-GOx-POD/NOS cascade ACPCAH are fully investigated. Both in vitro vivo tests demonstrate that this can be activated thus accelerating wound healing effectively. study highlights a competitive approach based on nanozymes for development all-in-one therapies.

Language: Английский

Citations

116
Sulfur-regulated defect engineering for enhanced ultrasonic piezocatalytic therapy of bacteria-infected bone defects DOI
Jie Lei, Chaofeng Wang, Xiaobo Feng

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 134624 - 134624

Published: Jan. 11, 2022

Language: Английский

Citations

102
Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy DOI
Yujie Zhu, Quguang Li, Chunjie Wang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 7326 - 7378

Published: March 13, 2023

Cancer thermal therapy, also known as hyperthermia has long been exploited to eradicate mass lesions that are now defined cancer. With the development of corresponding technologies and equipment, local therapies such radiofrequency ablation, microwave high-intensity focused ultrasound, have validated effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages adjacent normal tissues incomplete ablation particularly for large tumors, restricting their wide usage. Attributed versatile physiochemical properties, biomaterials specially designed potentiate treatments according unique working principles. Meanwhile, biomaterial-based delivery systems able bridge with other types treatment strategies chemotherapy, radiotherapy immunotherapy. Therefore, this review, we discuss recent progress functional reinforce by functioning sensitizers endow more efficient tumor-localized and/or vehicles synergize therapeutic modalities combined cancer treatments. Thereafter, provide a critical perspective on further biomaterial-assisted toward applications.

Language: Английский

Citations

92
An Intelligent Cell-Derived Nanorobot Bridges Synergistic Crosstalk Between Sonodynamic Therapy and Cuproptosis to Promote Cancer Treatment DOI
Kerong Chen, Anwei Zhou, Xinyuan Zhou

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 23(7), P. 3038 - 3047

Published: March 23, 2023

Recent progress in cuproptosis sheds light on the development of treatment approaches for advancing sonodynamic therapy (SDT) due to its unique cell death mechanism. Herein, we elaborately developed an intelligent cell-derived nanorobot (SonoCu), composed macrophage-membrane-camouflaged nanocarrier encapsulating copper-doped zeolitic imidazolate framework-8 (ZIF-8), perfluorocarbon, and sonosensitizer Ce6, synergistically triggering cuproptosis-augmented SDT. SonoCu not only improved tumor accumulation cancer-cell uptake through cell-membrane camouflaging but responded ultrasound stimuli enhance intratumor blood flow oxygen supply, which consequently overcame barriers activated cuproptosis. Importantly, SDT effectiveness could be further amplified by multiple mechanisms, including reactive species accumulation, proteotoxic stress, metabolic regulation, sensitized cancer death. Particularly, exhibited ultrasound-responsive cytotoxicity against cells healthy cells, endowing it with good biosafety. Therefore, present first anticancer combination cuproptosis, may inspire studies pursuing a rational multimodal strategy.

Language: Английский

Citations

91
Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet‐Based Sonosensitizers Via Crystalline‐to‐Amorphous Phase Transformation DOI
Tingting Hu,

Weicheng Shen,

Fanqi Meng

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(17)

Published: Feb. 13, 2023

Abstract Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other strategies. However, the current sonosensitizers used SDT normally exhibit low activity ultrasound (US)‐induced reactive oxygen species (ROS) generation. Herein, crystalline‐to‐amorphous phase transformation is reported as simple but powerful strategy to engineer ultrathin 2D CoW‐LDH and NiW‐LDH nanosheets highly efficient SDT. The from polycrystalline amorphous ones achieved through acid etching treatment. Importantly, one, (a‐CoW‐LDH) possess higher ROS generation under US irradiation, which ≈17 times commercial TiO 2 sonosensitizer. results suggest that enhanced performance a‐CoW‐LDH US‐induced may be attributed transformation‐induced defect electronic structure changes. After polyethylene glycol modification, can serve high‐efficiency sonosensitizer achieve cell death in vitro tumor eradication vivo irradiation.

Language: Английский

Citations

85
Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives DOI Creative Commons

Qinglong Guo,

Xingliang Dai, Mengyuan Yin

et al.

Military Medical Research, Journal Year: 2022, Volume and Issue: 9(1)

Published: June 9, 2022

Abstract Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor, and it associated with poor prognosis. Its characteristics of being highly invasive undergoing heterogeneous genetic mutation, as well presence blood–brain barrier (BBB), have reduced efficacy GBM treatment. The emergence a novel therapeutic method, namely, sonodynamic therapy (SDT), provides promising strategy for eradicating tumors via activated sonosensitizers coupled low-intensity ultrasound. SDT can provide tumor killing effects deep-seated tumors, such tumors. However, conventional cannot effectively reach region kill additional cells, especially cells. Efforts should be made to develop method help agents pass through BBB accumulate in With development multifunctional nanosensitizers newly emerging combination strategies, ability selectivity greatly improved are accompanied fewer side effects. In this review, we systematically summarize findings previous studies on GBM, focus recent developments directions future research.

Language: Английский

Citations

77
Cancer cell membrane-coated C-TiO2 hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy DOI
Shipeng Ning, Xingliang Dai,

Weiwei Tang

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 152, P. 562 - 574

Published: Sept. 5, 2022

Language: Английский

Citations

73
Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy DOI Open Access
Zhan Zhou, Tao Wang, Tingting Hu

et al.

Materials Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 7(8), P. 1684 - 1693

Published: Jan. 1, 2023

2D Al-TCPP MOF nanosheets were prepared via a simple solvothermal synthesis method without the need for any surfactants and found to be an effective sonosensitizer sonodynamic cancer therapy.

Language: Английский

Citations

68
Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies DOI Creative Commons
Qinglin Xu, Weijun Xiu, Qiang Li

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100559 - 100559

Published: Jan. 21, 2023

With the widespread prevalence of drug-resistant pathogens, traditional antibiotics have limited effectiveness and do not yield desired outcomes. Recently, alternative antibacterial therapies based on ultrasound (US) been explored to overcome crisis bacterial pathogens. Antimicrobial sonodynamic therapy (aSDT) offers an excellent solution that relies US irradiation produce reactive oxygen species (ROS) achieve antibiotic-free mediated antimicrobial effects. In addition, aSDT possesses advantage superior tissue penetrability compared light irradiation, demonstrating great feasibility in treating deep infections. Although existing conventional sonosensitizers can ROS for activity, some limitations, such as low penetration rate, nonspecific distribution poor production under hypoxic conditions, result suboptimal sterilization aSDT. emerging nanosonosensitizers enormous advantages high-performance agents aSDT, which deficiencies described above. Thus, nanosonosensitizer-mediated has a bright future management This review classifies current available provides overview mechanisms, biomedical applications, recent advances perspectives

Language: Английский

Citations

51
Titanium‐Based Nanoarchitectures for Sonodynamic Therapy‐Involved Multimodal Treatments DOI
Aziz Maleki, Mohammad Seyedhamzeh, Meng Yuan

et al.

Small, Journal Year: 2023, Volume and Issue: 19(12)

Published: Jan. 15, 2023

Sonodynamic therapy (SDT) has considerably revolutionized the healthcare sector as a viable noninvasive therapeutic procedure. It employs combination of low-intensity ultrasound and chemical entities, known sonosensitizer, to produce cytotoxic reactive oxygen species (ROS) for cancer antimicrobial therapies. With nanotechnology, several unique nanoplatforms are introduced sonosensitizers, including, titanium-based nanomaterials, thanks their high biocompatibility, catalytic efficiency, customizable physicochemical features. Additionally, developing sonosensitizers facilitates integration SDT with other treatment modalities (for example, chemotherapy, chemodynamic therapy, photodynamic photothermal immunotherapy), hence increasing overall results. This review summarizes most recent developments in tissue engineering using titanium mediated SDT. The synthesis strategies biosafety aspects Titanium-based also discussed. Finally, various challenges prospects its further development potential clinical translation highlighted.

Language: Английский

Citations

45