Small Methods,
Journal Year:
2022,
Volume and Issue:
6(11)
Published: Oct. 6, 2022
Abstract
Nanozymes
refer
to
nanomaterials
that
catalyze
enzyme
substrates
into
products
under
relevant
physiological
conditions
following
kinetics.
Compared
natural
enzymes,
nanozymes
possess
the
characteristics
of
higher
stability,
easier
preparation,
and
lower
cost.
Importantly,
magnetic,
fluorescent,
electrical
properties
nanomaterials,
making
them
promising
replacements
for
enzymes
in
industrial,
biological,
medical
fields.
On
account
rapid
development
recently,
their
application
potentials
regeneration
medicine
are
gradually
being
explored.
To
highlight
achievements
field,
this
review
summarizes
catalytic
mechanism
four
types
representative
nanozymes.
Then,
strategies
improve
biocompatibility
discussed.
covers
recent
advances
tissue
including
wound
healing,
nerve
defect
repair,
bone
regeneration,
cardiovascular
disease
treatment.
In
addition,
challenges
prospects
nanozyme
researches
summarized.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(8), P. 12687 - 12722
Published: Aug. 10, 2021
Hydrogels,
due
to
their
excellent
biochemical
and
mechnical
property,
have
shown
attractive
advantages
in
the
field
of
wound
dressings.
However,
a
comprehensive
review
functional
hydrogel
as
dressing
is
still
lacking.
This
work
first
summarizes
skin
healing
process
relates
evaluation
parameters
then
reviews
advanced
functions
dressings
such
antimicrobial
adhesion
hemostasis,
anti-inflammatory
anti-oxidation,
substance
delivery,
self-healing,
stimulus
response,
conductivity,
recently
emerged
monitoring
feature,
strategies
adopted
achieve
these
are
all
classified
discussed.
Furthermore,
applications
for
treatment
different
types
wounds
incisional
excisional
summarized.
Chronic
also
mentioned,
focus
attention
on
infected
wounds,
burn
diabetic
Finally,
future
directions
further
proposed.
Nano-Micro Letters,
Journal Year:
2021,
Volume and Issue:
14(1)
Published: Dec. 2, 2021
Abstract
Conductive
biomaterials
based
on
conductive
polymers,
carbon
nanomaterials,
or
inorganic
nanomaterials
demonstrate
great
potential
in
wound
healing
and
skin
tissue
engineering,
owing
to
the
similar
conductivity
human
skin,
good
antioxidant
antibacterial
activities,
electrically
controlled
drug
delivery,
photothermal
effect.
However,
a
review
highlights
design
application
of
for
engineering
is
lacking.
In
this
review,
fabrication
methods
with
various
structural
forms
including
film,
nanofiber,
membrane,
hydrogel,
sponge,
foam,
acellular
dermal
matrix
applications
corresponding
mechanism
promoting
process
were
summarized.
The
approaches
that
realize
their
value
wounds
via
three
main
strategies
(electrotherapy,
dressing,
assessment)
reviewed.
as
dressing
when
facing
different
acute
chronic
(infected
diabetic
wound)
monitoring
discussed
detail.
challenges
perspectives
designing
developing
multifunctional
are
proposed
well.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(2), P. 3194 - 3207
Published: Jan. 31, 2022
In
view
of
the
lack
a
specific
drug-sustained
release
system
that
is
responsive
to
chronic
wounds
type
II
diabetic
foot,
and
demands
for
frequent
movement
at
foot
wound,
pH/glucose
dual-responsive
metformin-released
adhesion-enhanced
self-healing
easy-removable
antibacterial
antioxidant
conductive
hemostasis
multifunctional
phenylboronic
acid
benzaldehyde
bifunctional
polyethylene
glycol-co-poly(glycerol
sebacic
acid)/dihydrocaffeic
l-arginine
cografted
chitosan
(PEGS-PBA-BA/CS-DA-LAG,
denoted
as
PC)
hydrogel
dressings
were
constructed
based
on
double
dynamic
bond
Schiff-base
phenylboronate
ester.
It
was
further
demonstrated
PC
promotes
wound
healing
by
reducing
inflammation
enhancing
angiogenesis
in
rat
model.
addition,
addition
metformin
(Met)
graphene
oxide
(GO),
well
their
synergy,
confirmed
better
promote
repair
vivo.
summary,
PC/GO/Met
hydrogels
with
stimuli-responsive
ability
easy
removability
have
shown
promoting
effect
athletic
provide
local-specific
drug
dual-response
strategy
treatment
feet.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(2), P. 1708 - 1733
Published: Jan. 20, 2022
Wound
dressings
based
on
nanomaterials
play
a
crucial
role
in
wound
treatment
and
are
widely
used
whole
range
of
medical
settings,
from
minor
to
life-threatening
tissue
injuries.
This
article
presents
an
educational
review
the
accumulating
knowledge
this
multidisciplinary
area
lay
out
challenges
opportunities
that
lie
ahead
ignite
further
faster
development
clinically
valuable
technologies.
The
analyzes
functional
advantages
nanomaterial-based
gauzes
hydrogels
as
well
hybrid
structures
thereof.
On
basis,
state-of-the-art
advances
transfer
(semi)blind
approaches
evaluation
state
smart
enable
real-time
monitoring
diagnostic
functions
could
help
during
healing.
explores
translation
related
aspects
into
real-world
use.
ongoing
future
associated
with
clinical
decisions
presented
reviewed.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2022,
Volume and Issue:
17(3), P. 353 - 384
Published: Jan. 24, 2022
Bacterial
infection
and
the
ever-increasing
bacterial
resistance
have
imposed
severe
threat
to
human
health.
And
contamination
could
significantly
menace
wound
healing
process.
Considering
sophisticated
process,
novel
strategies
for
skin
tissue
engineering
are
focused
on
integration
of
bioactive
ingredients,
antibacterial
agents
included,
into
biomaterials
with
different
morphologies
improve
cell
behaviors
promote
healing.
However,
a
comprehensive
review
anti-bacterial
dressing
enhance
has
not
been
reported.
In
this
review,
various
as
dressings
will
be
discussed.
Different
kinds
agents,
including
antibiotics,
nanoparticles
(metal
metallic
oxides,
light-induced
agents),
cationic
organic
others,
their
recent
advances
summarized.
Biomaterial
selection
fabrication
structures
forms,
films,
hydrogel,
electrospun
nanofibers,
sponge,
foam
three-dimension
(3D)
printed
scaffold
regeneration,
elaborated
Current
challenges
future
perspectives
presented
in
multidisciplinary
field.
We
envision
that
provide
general
insight
elegant
design
further
refinement
dressing.
ACS Applied Materials & Interfaces,
Journal Year:
2021,
Volume and Issue:
13(28), P. 33584 - 33599
Published: July 9, 2021
Stimuli-responsive
hydrogels
possess
unique
advantages
in
drug
delivery
due
to
their
variable
performance
and
status
based
on
the
external
environment.
In
present
study,
a
dual-responsive
(pH
reactive
oxygen
species
(ROS))
hydrogel
was
prepared
realize
release
properties
under
inflammatory
stimulation.
By
grafting
3-carboxy-phenylboronic
acid
gelatin
molecular
backbone
cross-linking
with
poly(vinyl
alcohol),
we
successfully
synthesized
inflammation-responsive
drug-loaded
after
encapsulation
vancomycin-conjugated
silver
nanoclusters
(VAN-AgNCs)
pH-sensitive
micelles
loaded
nimesulide
(NIM).
This
novel
design
not
only
retained
dynamic
functions
of
hydrogels,
such
as
injectability,
self-healing,
remodeling,
but
also
realized
sequential
on-demand
at
diabetic-infected
wound
sites.
this
work,
found
that
exhibited
excellent
biocompatibility
hemostasis
owing
enhanced
cell-adhesive
property
component.
The
significant
antibacterial
anti-inflammatory
effect
demonstrated
an
vitro
experiment.
Moreover,
vivo
experiment,
play
role
promoting
infected
healing
through
processes.
Collectively,
containing
VAN-AgNCs
NIM-loaded
has
great
potential
application
chronically
diabetic
treatment,
well
other
diseases.
Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
9, P. 461 - 474
Published: July 26, 2021
Bacterial
infection,
tissue
hypoxia
and
inflammatory
response
can
hinder
the
infected
wound
repair
process.
To
mitigate
above
issues,
tannic
acid-chelated
Fe-decorated
molybdenum
disulfide
nanosheets
(MoS2@TA/Fe
NSs)
with
dual
enzyme
activities
were
developed
anchored
to
a
multifunctional
hydrogel.
The
hydrogel
exhibited
excellent
antibacterial
ability
owing
combined
effects
of
photothermal
therapy
(PTT),
glutathione
(GSH)
loss,
peroxidase
(POD)-like
activity
(catalyse
H2O2
into
·OH
under
acid
condition)
MoS2@TA/Fe
NSs.
Benefitting
from
catalase
(CAT)-like
activity,
could
decompose
O2
at
neutral
pH
relieve
supply
adequate
O2.
POD-like
was
mainly
attributed
MoS2
NSs,
while
CAT-like
primarily
due
TA/Fe
complex.
Moreover,
NSs
endowed
outstanding
anti-oxidant
scavenge
redundant
reactive
oxygen
species
(ROS)
nitrogen
(RNS)
environment
maintain
balance
antioxidant
systems
prevent
inflammation.
In
addition,
inhibit
release
factors
for
anti-inflammatory
property
TA.
TA
retained
partial
phenolic
hydroxyl
groups,
which
cross-linked
network
structure
promoted
adhesion
hydrogels.
Due
dynamic
boron
ester
bonds
between
polyvinyl
alcohol
(PVA),
dextran
(Dex),
MoS2@TA/Fe,
borax,
demonstrated
fast
self-healing
rapid
shape
adaptability.
This
shape-adaptable
adhesive
fill
whole
closely
contact
wound,
ensuring
that
it
achieved
its
functions
maximum
efficiency.
nanozyme-anchored
showed
high
potential
bacteria-infected
healing.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(6), P. 7680 - 7689
Published: Feb. 7, 2022
Antioxidant
hydrogel
has
exhibited
great
potential
for
diabetic
wound
treatment.
However,
it
is
still
a
difficult
challenge
to
realize
reactive
oxygen
species
(ROS)
scavenging
in
an
intelligent
manner.
Herein,
we
designed
novel
glucose-responsive
antioxidant
hybrid
enhanced
repair.
In
this
study,
phenylboronic
acid
(PBA)
with
unique
glucose-sensitivity
was
modified
onto
hyaluronic
(HA)
chain
by
one-step
synthesis,
which
then
incorporated
into
polyethylene
glycol
diacrylates
(PEG-DA)
matrix
obtain
(PEG-DA/HA-PBA).
Then,
myricetin
(MY)
molecules
strong
activity
were
immobilized
the
formation
of
dynamic
borate
bond
between
polyphenol
group
MY
and
HA-PBA.
The
PEG-DA/HA-PBA/MY
(PHM)
achieved
glucose-triggered
release,
efficient
ROS-scavenging
(>80.0%),
also
reshaped
hostile
oxidative
microenvironment
(reduced
MDA
increased
SOD
GSH/GSSG
levels).
Furthermore,
vitro
vivo
results
indicated
that
PHM
platform
effectively
ameliorated
inflammatory
response
(decreased
IL-6
Il-10
expression),
accelerated
angiogenesis
(increased
VEGF
CD
31
tissue
remodeling
within
20
days,
better
than
nonresponsive
PEG-DA/MY
(PM)
promoting
healing.
All
strongly
suggested
