European Polymer Journal,
Journal Year:
2024,
Volume and Issue:
211, P. 113026 - 113026
Published: April 8, 2024
Chronic
diabetic
wounds
persist
as
a
healthcare
challenge
and
therefore
require
the
use
of
innovative
therapeutic
approaches.
Among
emerging
solutions,
hydrogels
stand
out
promising
avenue
for
wound
healing
due
to
their
unique
properties
versatile
applications,
capable
addressing
complex
challenging
microenvironment
that
characterizes
such
wounds.
In
this
work,
through
detailed
analysis
relevant
experimental
studies,
we
highlight
multifunctionality
hydrogels,
namely
ability
promote
tissue
attachment,
prevent
scarring,
fight
infection,
attenuate
inflammation,
facilitate
electrical
signaling,
control
bleeding,
repair
damage
autonomously,
exhibit
responses
tailored
specific
characteristics.
The
collective
findings
from
these
studies
emphasize
attributes
in
challenges.
By
elucidating
crucial
insights,
work
seeks
lay
groundwork
both
academics
industries
development
implementation
effective
hydrogel-based
strategies
can
significantly
improve
outcomes,
offering
new
hope
patients
suffering
chronic
Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Aug. 22, 2023
The
treatment
of
chronic
and
non-healing
wounds
in
diabetic
patients
remains
a
major
medical
problem.
Recent
reports
have
shown
that
hydrogel
wound
dressings
might
be
an
effective
strategy
for
treating
due
to
their
excellent
hydrophilicity,
good
drug-loading
ability
sustained
drug
release
properties.
As
typical
example,
hyaluronic
acid
dressing
(Healoderm)
has
been
demonstrated
clinical
trials
improve
wound-healing
efficiency
healing
rates
foot
ulcers.
However,
the
degradation
behavior
clinically-used
cannot
adjusted
according
microenvironment.
Due
intricacy
wounds,
antibiotics
other
medications
are
frequently
combined
with
practice,
although
these
easily
hindered
by
hostile
environment.
In
this
case,
scientists
created
responsive-hydrogel
based
on
microenvironment
features
(such
as
high
glucose
low
pH)
or
external
stimuli
light
magnetic
field)
achieve
controllable
release,
gel
degradation,
improvements
order
overcome
issues.
These
anticipated
play
significant
role
therapeutic
dressings.
Here,
we
review
recent
advances
towards
healing,
focus
structure
design,
principle
responsiveness,
degradation.
Last
but
not
least,
advantages
limitations
responsive-hydrogels
applications
will
also
discussed.
We
hope
contribute
furthering
progress
hydrogels
improved
practical
application.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
18, P. 100508 - 100508
Published: Nov. 30, 2022
Poor
wound
healing
after
diabetes
mellitus
remains
a
challenging
problem,
and
its
pathophysiological
mechanisms
have
not
yet
been
fully
elucidated.
Persistent
bleeding,
disturbed
regulation
of
inflammation,
blocked
cell
proliferation,
susceptible
infection
impaired
tissue
remodeling
are
the
main
features
diabetic
healing.
Conventional
dressings,
including
gauze,
films
bandages,
limited
function.
They
generally
act
as
physical
barriers
absorbers
exudates,
which
fail
to
meet
requirements
whol
process.
Wounds
in
patients
typically
heal
slowly
due
hyperglycemia
within
bed.
Once
bacterial
cells
develop
into
biofilms,
wounds
will
exhibit
robust
drug
resistance.
Recently,
application
stimuli-responsive
hydrogels,
also
known
"smart
hydrogels",
for
has
attracted
particular
attention.
The
basic
feature
this
system
is
capacities
change
mechanical
properties,
swelling
ability,
hydrophilicity,
permeability
biologically
active
molecules,
etc.,
response
various
stimuli,
temperature,
potential
hydrogen
(pH),
protease
other
biological
factors.
Smart
hydrogels
can
improve
therapeutic
efficacy
limit
total
toxicity
according
characteristics
wounds.
In
review,
we
summarized
mechanism
It
hoped
that
work
provide
some
inspiration
suggestions
research
field.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 13, 2023
Abstract
The
healing
of
diabetic
wounds
is
hindered
by
various
factors,
including
bacterial
infection,
macrophage
dysfunction,
excess
proinflammatory
cytokines,
high
levels
reactive
oxygen
species,
and
sustained
hypoxia.
These
factors
collectively
impede
cellular
behaviors
the
process.
Consequently,
this
review
presents
intelligent
hydrogels
equipped
with
multifunctional
capacities,
which
enable
them
to
dynamically
respond
microenvironment
accelerate
wound
in
ways,
stimuli
‐responsiveness,
injectable
self‐healing,
shape
‐memory,
conductive
real‐time
monitoring
properties.
relationship
between
multiple
functions
also
discussed.
Based
on
wounds,
antibacterial,
anti‐inflammatory,
immunomodulatory,
antioxidant,
pro‐angiogenic
strategies
are
combined
hydrogels.
application
repair
systematically
discussed,
aiming
provide
guidelines
for
fabricating
exploring
role
therapeutic
processes.
BMEMat,
Journal Year:
2023,
Volume and Issue:
1(2)
Published: April 15, 2023
Abstract
Due
to
global
aging
problems,
the
rising
number
of
patients
suffering
from
chronic
or
hard‐to‐heal
acute
wounds
imposes
a
significant
burden
on
healthcare
systems.
Wound
healing
is
complicated
and
dynamic
physiological
process
with
distinct
molecular
cellular
levels
at
each
phase.
Despite
numerous
strategies
advanced
wound
dressings
being
developed,
successful
management
through
smart
dressing
materials
that
can
adapt
changing
microenvironments
address
needs
different
stages
remains
big
challenge.
Over
last
decade,
hydrogel‐based
have
emerged
as
one
most
potent
biomaterials
for
treatment
favorable
biological
characteristics
high
potential
active
intervention
during
wound‐curing
process.
In
current
contribution,
we
present
recent
progress
in
hydrogel
regulate
release
therapeutics
response
external
stimuli
(such
light)
well
endogenous
changes
environments
(e.g.,
temperature,
pH,
glucose,
reactive
oxygen
species)
facilitate
healing.
We
also
introduce
cutting‐edge
technologies
intelligent
“sense‐and‐treat”
combination
built‐in
sensors
sensing
molecules
responsive
hydrogels,
which
enable
real‐time
monitoring
conditions
prompt
on‐demand
therapy.
Biomaterials Science,
Journal Year:
2022,
Volume and Issue:
10(15), P. 4058 - 4076
Published: Jan. 1, 2022
Multifunctional
wound
dressings
or
smart
with
pro-angiogenic
function,
antibacterial
properties,
anti-inflammatory/antioxidant
activity
and
tissue
adhesion
for
chronic
repair.
Regenerative Biomaterials,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 1, 2022
The
synergistic
effect
of
antibacterial
and
anti-inflammatory
is
needed
to
overcome
the
problem
wound
healing
difficulties.
Based
on
favorable
zinc
ions
(Zn2+)
physicochemical
properties
metal
organic
frameworks
(MOFs),
we
prepared
nanosized
zinc-based
MOF:
Zn-BTC
with
ability
slowly
release
Zn2+.
In
cellular
levels,
possessed
lower
toxicity
fibroblasts
enhanced
capacity
cell
proliferation
migration.
It
also
had
good
bactericidal
multiple
drug-resistant
bacteria
by
reducing
41.4%
MRSA
47.2%
Escherichia
coli.
addition,
displayed
lowering
expression
antioxidant
genes:
superoxide
dismutase
1,
2
interleukin
6,
enhancing
transforming
growth
factors-β
type
I
collagen.
Finally,
it
demonstrated
that
could
effectively
improve
skin
SD
rats
no
major
organs.
biocompatibility,
gave
a
new
insight
designing
novel
MOFs
for
promoting
healing.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(28), P. 31737 - 31750
Published: July 8, 2022
Chronic
wounds
cannot
proceed
through
the
normal,
orderly,
and
timely
sequence
of
repair.
The
adverse
cycle
between
excess
reactive
oxide
species
(ROS)
a
persistent
inflammatory
response
is
an
important
mechanism
impaired
wound
healing.
Herein,
by
combining
intrinsic
bioactivities
natural
polysaccharides
drugs,
glycosaminoglycan-based
hydrogel
delivery
system
proposed
to
regulate
microenvironment.
Dynamic
supramolecular
cross-linking
enables
easily
encapsulate
drug
fully
fill
area.
As
backbone
hydrogel,
heparin
captures
chemokines
at
site,
while
hyaluronic
acid
mimics
function
ECM.
hydrophobic
curcumin
has
been
ingeniously
encapsulated
in
micellization,
thereby
exerting
good
ROS
scavenging
ability
anti-inflammatory
activity.
Evaluations
diabetic
mice
showed
that
this
antioxidant
was
effective
reducing
influx
immune
cells
site
down-regulating
response.
Accelerated
healing
also
observed,
as
evidenced
faster
re-epithelialization
better
ECM
remodeling.
can
microenvironment
from
multiple
aspects
achieve
regression
repair,
which
may
provide
new
therapeutic
strategy
for
chronic
wounds.
