Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(10), P. 1648 - 1648
Published: May 12, 2022
This
paper
aimed
to
develop
two
types
of
support
materials
with
a
mesoporous
structure
mobile
crystalline
matter
(known
in
the
literature
as
MCM,
namely
MCM-41
and
MCM-48)
load
them
gallic
acid.
Soft
templating
methodology
was
chosen
for
preparation
structures-the
cylindrical
micelles
certain
structural
characteristics
being
formed
due
hydrophilic
hydrophobic
intermolecular
forces
which
occur
between
molecules
surfactants
(cetyltrimethylammonium
bromide-CTAB)
when
minimal
micellar
ionic
concentration
is
reached.
These
supports
were
loaded
acid
using
three
different
MCM-gallic
ratios
(1:0.41;
1:0.82
1:1.21)-and
their
characterizations
by
FTIR,
SEM,
XRD,
BET
drug
release
performed.
It
worth
mentioning
that
loading
carried
out
vacuum-assisted
methodology:
are
firstly
kept
under
vacuum
at
~0.1
barr
30
min
followed
addition
polyphenol
solutions.
The
solutions
adapted
such
final
volume
covered
wet
and-in
this
case-upon
reaching
normal
atmospheric
pressure,
solution
pushed
inside
pores,
thus
polyphenols
mainly
pores.
Based
on
SBET
data,
it
can
be
seen
specific
surface
area
decreased
considerably
increasing
ratio
acid;
3.07
4.25
times
MCM-48,
respectively.
sample
highest
content
further
evaluated
from
biological
point
view,
alone
or
association
amoxicillin
administration.
As
expected,
MCM-48
not
protective
against
infections-but,
acid,
potentiated
inhibition
recorded
tested
gram-negative
bacterial
strains.
Moreover,
important
mention
these
systems
efficient
recovery
gut
microbiota
after
exposure
antibiotics,
instance.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(19), P. 3323 - 3323
Published: Sept. 28, 2024
Gastric
cancer
(GC)
is
the
second
most
common
cause
of
cancer-related
death
worldwide
and
a
serious
public
health
concern.
This
high
rate
mostly
caused
by
late-stage
diagnoses,
which
lead
to
poor
treatment
outcomes.
Radiation
immunotherapy
targeted
therapies
are
becoming
increasingly
popular
in
GC
treatment,
addition
surgery
systemic
chemotherapy.
In
this
review,
we
have
focused
on
both
vitro
vivo
research,
presents
summary
recent
developments
for
gastric
cancer.
We
explore
therapy
approaches,
including
integrin
receptors,
HER2,
Claudin
18,
glutathione-responsive
systems.
For
instance,
targeting
receptors
such
as
αvβ3
αvβ5
integrins
shown
promise
enhancing
diagnostic
precision
efficacy.
Furthermore,
nanotechnology
provides
novel
approaches
drug
delivery
imaging.
These
include
nanoplatforms
cyclic
RGD
peptide-conjugated
nanoparticles.
strategies
seek
reduce
toxicity
while
increasing
specificity
To
sum
up,
review
addresses
significance
personalized
medicine
advancements
cancer-targeted
therapies.
It
explores
potential
methods
prognosis
future.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(7), P. 1564 - 1564
Published: March 31, 2024
Methotrexate
(MTX)
has
poor
water
solubility
and
low
bioavailability,
cancer
cells
can
become
resistant
to
it,
which
limits
its
safe
delivery
tumor
sites
reduces
clinical
efficacy.
Herein,
we
developed
novel
redox-responsive
hybrid
nanoparticles
(NPs)
from
hyaluronic
acid
(HA)
3-mercaptopropionic
(MPA)-coated
gold
NPs
(gold@MPA
NPs),
were
further
conjugated
with
folic
(FA).
The
design
of
FA-HA-ss-gold
aimed
at
enhancing
cellular
uptake
specifically
in
using
an
active
FA/HA
dual
targeting
strategy
for
enhanced
eradication.
MTX
was
successfully
encapsulated
into
NPs,
drug
encapsulation
efficiency
(EE)
as
high
>98.7%.
physicochemical
properties
the
investigated
terms
size,
surface
charges,
wavelength
reflectance,
chemical
bonds.
released
a
sustained
manner
glutathione
(GSH).
experiments
showed
effective
over
HA-ss-gold
deep
tumor.
Moreover,
release
studies
provided
strong
evidence
that
serve
GSH-responsive
carriers.
In
vitro,
anti-tumor
activity
tests
FA-HA-ss-gold/MTX
exhibited
significantly
higher
cytotoxic
against
both
human
cervical
(HeLa)
breast
(BT-20)
compared
only
HA-ss-gold/MTX
while
being
embryonic
kidney
(HEK-293)
cells.
Therefore,
this
present
study
suggests
are
promising
nanocarriers
stable,
controllable,
biocompatible,
biodegradable,
cell
targetability
hydrophobic
anticancer
drugs.
Vaccines,
Journal Year:
2022,
Volume and Issue:
10(9), P. 1493 - 1493
Published: Sept. 7, 2022
Cancer
immunotherapy
moderates
the
immune
system’s
ability
to
fight
cancer.
Due
its
extreme
complexity,
scientists
are
working
put
together
all
puzzle
pieces
get
a
clearer
picture
of
system.
Shreds
available
evidence
show
connection
between
cancer
and
Immune
responses
tumors
lymphoid
malignancies
influenced
by
B
cells,
γδT
NK
dendritic
cells
(DCs).
immunotherapy,
which
encompasses
adoptive
therapy,
monoclonal
antibodies
(mAbs),
checkpoint
CART
has
revolutionized
contemporary
treatment.
This
article
reviews
recent
developments
in
cell
regulation
immunotherapy.
Various
options
treat
many
diseases,
particularly
cancer,
due
progress
various
immunotherapies,
such
as
antibodies,
recombinant
proteins,
vaccinations
(both
preventative
curative),
cellular
cytokines.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
33(2)
Published: Nov. 23, 2022
Abstract
Chronic
diseases
claim
millions
of
lives
every
year,
and
it
is
great
significance
to
explore
develop
advanced
drugs
improve
the
cure
rate
chronic
diseases.
Nanotheranostics
are
innovative
strategies
that
enable
integration
diagnostic
therapeutic
properties
into
a
single
nanosystem.
Despite
success
in
nanotheranostics,
their
applications
nanotheranostics
nanomedicine
still
infancy.
This
because
each
disease
has
its
corresponding
characteristic
pathological
microenvironment,
which
motivates
development
endogenous
biomarker‐responsive
nanosystems
meet
requirements
diagnosis
treatment.
Herein,
recent
progress
presented
biomedical
applications.
First,
classified
eight
subsections
according
type
diseases,
including
tumors,
cardiovascular
neurological
Wilson's
liver
kidney
diabetes
mellitus,
rheumatoid
arthritis.
In
following,
variety
intriguing
biomarkers‐responsive
briefly
elaborated,
such
as
biosensing,
diagnosis,
therapy,
combined
theranostics,
early
evaluation
therapy
effect,
etc.
Finally,
challenges
future
directions
from
research
clinical
translation
these
responsive
also
presented.
Small,
Journal Year:
2023,
Volume and Issue:
19(37)
Published: May 24, 2023
Canonical
phototherapeutics
have
several
limitations,
including
a
lack
of
tumor
selectivity,
nondiscriminatory
phototoxicity,
and
hypoxia
aggravation.
The
microenvironment
(TME)
is
characterized
by
hypoxia,
acidic
pH,
high
levels
H2
O2
,
GSH,
proteases.
To
overcome
the
shortcomings
canonical
phototherapy
achieve
optimal
theranostic
effects
with
minimal
side
effects,
unique
TME
characteristics
are
employed
in
development
phototherapeutic
nanomedicines.
In
this
review,
effectiveness
three
strategies
for
developing
advanced
based
on
various
examined.
first
strategy
involves
targeted
delivery
to
tumors
assistance
TME-induced
nanoparticle
disassembly
or
surface
modification.
second
near-infrared
absorption
increase-induced
activation
triggered
factors.
third
enhancing
therapeutic
efficacy
ameliorating
TME.
functionalities,
working
principles,
significance
applications
highlighted.
Finally,
possible
challenges
future
perspectives
further
discussed.
