Recent advances in conductive hydrogels: classifications, properties, and applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(2), P. 473 - 509

Published: Dec. 9, 2022

Hydrogel-based conductive materials for smart wearable devices have attracted increasing attention due to their excellent flexibility, versatility, and outstanding biocompatibility. This review presents the recent advances in multifunctional hydrogels electronic devices. First, with different components are discussed, including pure single network based on polymers, additional additives (i.e., nanoparticles, nanowires, nanosheets), double additives. Second, a variety of functionalities, self-healing, super toughness, self-growing, adhesive, anti-swelling, antibacterial, structural color, hydrophobic, anti-freezing, shape memory external stimulus responsiveness introduced detail. Third, applications flexible illustrated strain sensors, supercapacitors, touch panels, triboelectric nanogenerator, bioelectronic devices, robot). Next, current challenges facing summarized. Finally, an imaginative but reasonable outlook is given, which aims drive further development future.

Language: Английский

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Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(8), P. 13022 - 13036

Published: Aug. 3, 2022

Burns are a common health problem worldwide and highly susceptible to bacterial infections that difficult handle with ordinary wound dressings. Therefore, burn repair is extremely challenging in clinical practice. Herein, series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) good electrical conductivity antioxidant activity were prepared on the basis quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), polydopamine-coated polypyrrole nanowires (PPY@PDA NWs). These Schiff base cross-links between aminoglycoside antibiotic TOB OD enable be slowly released responsive pH. Interestingly, acidic substances during bacteria growth process can induce on-demand release TOB, avoiding abuse antibiotics. The antibacterial results showed QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations Pseudomonas aeruginosa (PA), Staphylococcus aureus, Escherichia coli short time bactericidal effect for up 11 days an agar plate diffusion experiment, while showing vivo activity. Excellent long-lasting properties make it suitable severely infected wounds. Furthermore, incorporation PPY@PDA endowed near-infrared (NIR) irradiation assisted drug-resistant bacteria, conductivity, Most importantly, PA-infected model, more effectively controlled inflammation levels promoted collagen deposition, vascular generation, earlier closure compared Tegaderm smart delivery advantageous bacterial-infected healing.

Language: Английский

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Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: Sept. 13, 2022

Hydrogels with multifunctionalities, including sufficient bonding strength, injectability and self-healing capacity, responsive-adhesive ability, fault-tolerant repeated tissue adhesion, are urgently demanded for invasive wound closure healing. Motivated by the adhesive mechanism of mussel brown algae, bioinspired dynamic bonds cross-linked multifunctional hydrogel is designed based on sodium alginate (SA), gelatin (GT) protocatechualdehyde, ferric ions added, sutureless post-wound-closure. The through Schiff base bond, catechol-Fe coordinate bond strong interaction between GT temperature-dependent phase transition SA, endows resulting mechanical strength efficient closure, reopened wounds. Moreover, properties endowed mispositioning to be removed/repositioned, which conducive adhesion adhesives during surgery. Besides, hydrogels present good biocompatibility, near-infrared-assisted photothermal antibacterial activity, antioxidation thermo-responsive reversible hemostatic effect. in vivo incision evaluation demonstrated their capability promote post-wound-closure healing incisions, indicating that developed dressing could serve as versatile sealant.

Language: Английский

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An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(48)

Published: Oct. 7, 2023

Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study proposes novel approach treating wounds, utilizing immunomodulatory hydrogel achieve self‐cascade glucose depletion ROS scavenging regulate microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) dressing is developed facilitate efficient hyperthermia‐enhanced local scavenging. Mechanistically, vitro/vivo experiments RNA sequencing analysis demonstrate that GHM3 disrupts ROS‐inflammation cascade cycle downregulates ratio of M1/M2 macrophages, consequently improving outcomes dorsal skin wounds rats. In conclusion, this proposed offers facile, safe, highly treatment modality DFUs.

Language: Английский

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Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)

Published: Aug. 6, 2023

Hydrogels with tailor-made swelling-shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients metabolites, well drug diffusion release, hydrogels high capacity been widely applicated full-thickness skin healing tissue regeneration, delivery. Nevertheless, fields adhesives internal soft-tissue healing, bioelectronics, non-swelling play very important functions owing to their stable macroscopic dimension physical performance physiological environment. Moreover, negative behavior (i.e., shrinkage) can be exploited drive noninvasive closure, achieve resolution enhancement hydrogel scaffolds. In addition, it help push out entrapped drugs, thus promote release. However, there still has not general review constructions applications from viewpoint properties. Therefore, this summarizes tactics employed so far tailoring applications. And relatively comprehensive understanding current progress future challenge different features provided potential clinical translations.

Language: Английский

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Multiple Stimuli‐Responsive Nanozyme‐Based Cryogels with Controlled NO Release as Self‐Adaptive Wound Dressing for Infected Wound Healing

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(31)

Published: April 23, 2023

Abstract Wound with drug‐resistant bacterial infections has become a serious challenge for the healthcare system, and designing wound dressing to self‐adapt need of different stage healing remains challenging. Herein, self‐adaptive dressings multiple stimuli‐responsiveness antibacterial activity are developed. Specifically, MoS 2 carrying reactive oxygen species (ROS) responsive nitric oxide (NO) release precursor L‐arginine (MSPA) is designed incorporated into carboxymethyl chitosan/ poly( N‐isopropylacrylamide) based cryogels (CMCS/PNIPAM) responsiveness (pH, near infrared (NIR), temperature) form that adapt therapeutic needs stages in infected healing. In response slightly acidic environment infection, assist capture capacity through acid‐triggered protonation behavior, effectively enhance photodynamic efficiency. Controllable on‐demand delivery ROS, NO, remote management biofluid achieved NIR light as trigger switch. The stimuli‐responsive nanozyme‐based efficiently eliminate MRSA biofilm NO assisted photodynamicand photothermal therapy (PDT&PTT). enzyme‐like activities relieved oxidative damage. Notably, these reduce alleviated stress, accelerate collagen deposition angiogenesis wounds, indicating provide new ideas treatment.

Language: Английский

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Physical dynamic double-network hydrogels as dressings to facilitate tissue repair

Nature Protocols, Journal Year: 2023, Volume and Issue: 18(11), P. 3322 - 3354

Published: Sept. 27, 2023

Language: Английский

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Chitosan-based hydrogel wound dressing: From mechanism to applications, a review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 244, P. 125250 - 125250

Published: June 10, 2023

Language: Английский

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Responsive hydrogel dressings for intelligent wound management

BMEMat, Journal Year: 2023, Volume and Issue: 1(2)

Published: April 15, 2023

Abstract Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐heal acute wounds imposes a significant burden on healthcare systems. Wound healing is complicated and dynamic physiological process with distinct molecular cellular levels at each phase. Despite numerous strategies advanced wound dressings being developed, successful management through smart dressing materials that can adapt changing microenvironments address needs different stages remains big challenge. Over last decade, hydrogel‐based have emerged as one most potent biomaterials for treatment favorable biological characteristics high potential active intervention during wound‐curing process. In current contribution, we present recent progress in hydrogel regulate release therapeutics response external stimuli (such light) well endogenous changes environments (e.g., temperature, pH, glucose, reactive oxygen species) facilitate healing. We also introduce cutting‐edge technologies intelligent “sense‐and‐treat” combination built‐in sensors sensing molecules responsive hydrogels, which enable real‐time monitoring conditions prompt on‐demand therapy.

Language: Английский

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Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: Status and trends

Materials Today Bio, Journal Year: 2022, Volume and Issue: 16, P. 100429 - 100429

Published: Sept. 15, 2022

Language: Английский

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