Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

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Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7901 - 7910

Published: April 13, 2023

The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity nanozymes and improve therapeutic effect nanozyme therapy. Piezoelectric materials, which are capable generating a built-in field under ultrasound (US), not only but also enable piezoelectric sonodynamic therapy (SDT). In this study, sonosensitizer based on Hf-based metal–organic framework (UIO-66) Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate inside promotes electron–hole separation produces reactive oxygen species (ROS). introduction NPs facilitated electron transfer, inhibited recombination pairs improved properties UIO-66. value constant (d33) increased from 71 122 pmV–1 after deposition NPs. addition, intrinsic catalase peroxidase activities were 2-fold induced exposure. vivo in vitro experiments revealed that proposed kill cancer cells inhibit tumor growth mice enhanced SDT sensitizer work proved be candidate used for multiple modalities

Language: Английский

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Design strategies and effect comparisons toward efficient piezocatalytic system

Nano Energy, Journal Year: 2022, Volume and Issue: 107, P. 108093 - 108093

Published: Dec. 15, 2022

Language: Английский

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Recent advances in nanoparticle-mediated antibacterial applications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215075 - 215075

Published: Feb. 21, 2023

Language: Английский

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Piezoelectricity, Pyroelectricity, and Ferroelectricity in Biomaterials and Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 16, 2023

Abstract Piezoelectric, pyroelectric, and ferroelectric materials are considered unique biomedical due to their dielectric crystals asymmetric centers that allow them directly convert various primary forms of energy in the environment, such as sunlight, mechanical energy, thermal into secondary electricity chemical energy. These possess exceptional conversion ability excellent catalytic properties, which have led widespread usage within fields. Numerous applications demonstrated great potential with these materials, including disease treatment, biosensors, tissue engineering. For example, piezoelectric used stimulate cell growth bone regeneration, while pyroelectric applied skin cancer detection imaging. Ferroelectric even found use neural implants record electrical activity brain. This paper reviews relationship between ferroelectric, piezoelectric, effects fundamental principles different reactions. It also highlights preparation methods three significant progress made applications. The review concludes by presenting key challenges future prospects for efficient catalysts based on nanomaterials

Language: Английский

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Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 18, 2023

Abstract With the development of engineered nanomaterials and nanomedicines, utilization to generate excessive reactive oxygen species under exogenous ultrasound (US) irradiation for realizing disease therapy, namely sonodynamic therapy (SDT), has attracted widespread attention. Compared with traditional photodynamic US shows deeper tissue penetration reach deep‐seated location. However, high‐efficiency sonosensitizers remains one gravest challenges in current related research future clinical application. Latterly, benefiting from piezotronic piezo‐phototronic effects, novel based on piezoelectric semiconductor (PS) have exhibited inspiring application prospects SDT. In this review, we outline structures physicochemical properties PS that potential applications SDT, introduce presumed mechanisms Then, latest progress as cancer antibacterial are summarized. Finally, existing trends field prospected.

Language: Английский

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Fundamentals, advances and perspectives of piezocatalysis: A marriage of solid-state physics and catalytic chemistry

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 138, P. 101161 - 101161

Published: July 16, 2023

Piezocatalysis, an evolving catalytic technology built on the piezoelectric properties of catalysts, breaks down barrier between mechanical energy and chemical energy. The potential difference that arises from deformation a material is commonly termed 'piezopotential'. Piezopotential has been demonstrated to facilitate manipulation band structure and/or charge carrier separation. Despite significant efforts design materials understand mechanism piezoelectrically enhanced chemistry through semiconductor physics, there remains opportunity review relationships performance piezo/ferroelectric properties. Herein, we provide comprehensive summary mechanisms correlated physical in field piezocatalysis. A fundamental understanding structural based solid-state physics can be used shed light future development In addition, types materials, strategies for catalysis efficiency enhancement, up-to-date applications environment remediation, renewable conversion, biomedicine biotechnology are discussed. Finally, perspectives designing developing highly active piezocatalysts using guidelines physicochemical proposed.

Language: Английский

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An Emerging Family of Piezocatalysts: 2D Piezoelectric Materials

Small, Journal Year: 2023, Volume and Issue: 19(44)

Published: June 29, 2023

Abstract Piezocatalysis is an emerging technique that holds great promise for the conversion of ubiquitous mechanical energy into electrochemical through piezoelectric effect. However, energies in natural environment (such as wind energy, water flow and noise) are typically tiny, scattered, featured with low frequency power. Therefore, a high response to these tiny critical achieving piezocatalytic performance. In comparison nanoparticles or 1D materials, 2D materials possess characteristics such flexibility, easy deformation, large surface area, rich active sites, showing more future practical applications. this review, state‐of‐the‐art research progresses on their applications piezocatalysis provided. First, detailed description offered. Then comprehensive summary presented examines various fields, including environmental remediation, small‐molecule catalysis, biomedicine. Finally, main challenges prospects discussed. It expected review can fuel application piezocatalysis.

Language: Английский

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Hollow-structured BaTiO3 nanoparticles with cerium-regulated defect engineering to promote piezocatalytic antibacterial treatment

Applied Catalysis B Environment and Energy, Journal Year: 2023, Volume and Issue: 328, P. 122520 - 122520

Published: Feb. 24, 2023

Language: Английский

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Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100559 - 100559

Published: Jan. 21, 2023

With the widespread prevalence of drug-resistant pathogens, traditional antibiotics have limited effectiveness and do not yield desired outcomes. Recently, alternative antibacterial therapies based on ultrasound (US) been explored to overcome crisis bacterial pathogens. Antimicrobial sonodynamic therapy (aSDT) offers an excellent solution that relies US irradiation produce reactive oxygen species (ROS) achieve antibiotic-free mediated antimicrobial effects. In addition, aSDT possesses advantage superior tissue penetrability compared light irradiation, demonstrating great feasibility in treating deep infections. Although existing conventional sonosensitizers can ROS for activity, some limitations, such as low penetration rate, nonspecific distribution poor production under hypoxic conditions, result suboptimal sterilization aSDT. emerging nanosonosensitizers enormous advantages high-performance agents aSDT, which deficiencies described above. Thus, nanosonosensitizer-mediated has a bright future management This review classifies current available provides overview mechanisms, biomedical applications, recent advances perspectives

Language: Английский

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