Acta Materialia, Journal Year: 2025, Volume and Issue: unknown, P. 120770 - 120770
Published: Jan. 1, 2025
Language: Английский
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)
Published: June 22, 2024
Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.
Language: Английский
Citations
36
Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 47, P. 191 - 206
Published: June 27, 2024
The regenerative capacity of bone is indispensable for growth, given that accidental injury almost inevitable. Bone relevant the aging population globally and repair large defects after osteotomy (e.g., following removal malignant tumours). Among many therapeutic modalities proposed to regeneration, electrical stimulation has attracted significant attention owing its economic convenience exceptional curative effects, various electroactive biomaterials have emerged. This review summarizes current knowledge progress regarding strategies improving repair. Such range from traditional methods delivering via electroconductive materials using external power sources self-powered biomaterials, such as piezoelectric nanogenerators. Electrical osteogenesis are related piezoelectricity. examines cell behaviour potential mechanisms electrostimulation in healing, aiming provide new insights regeneration biomaterials. roles rehabilitating microenvironment facilitate addressing whereby cues mediate regeneration. Interactions between osteogenesis-related cells summarized, leading proposals use stimulation-based therapies accelerate healing.
Language: Английский
Citations
17
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(32), P. 22348 - 22359
Published: Aug. 1, 2024
Sonopiezoelectric therapy, an ultrasound-activated piezoelectric nanomaterial for tumor treatment, has emerged as a novel alternative modality. However, the limited catalytic efficiency is serious bottleneck its practical application. Excellent catalysts with high coefficients, good deformability, large mechanical impact surface area, and abundant catalytically active sites still need to be developed urgently. In this study, classical ferroelectric material, bismuth titanate (Bi4Ti3O12, BTO), selected sonopiezoelectric sensitizer therapy. BTO generates electron–hole pairs under ultrasonic irradiation, which can react substrates in sonocatalytic-driven redox reaction. Aiming further improve activity of BTO, modification oxygen vacancies treatment corona polarization are envisioned study. Notably, reduces bandgap inhibits recombination. Additionally, immobilized built-in electric field on promoting separation electrons holes. Consequently, these modifications greatly sonocatalytic situ generation cytotoxic ROS CO, effectively eradicating tumor.
Language: Английский
Citations
17
Materials Horizons, Journal Year: 2023, Volume and Issue: 11(4), P. 876 - 902
Published: Dec. 1, 2023
The structure of this review includes applications MXenes in drug delivery, tissue engineering, antimicrobial, and biosensors.
Language: Английский
Citations
32
Nano Today, Journal Year: 2024, Volume and Issue: 55, P. 102208 - 102208
Published: Feb. 29, 2024
Language: Английский
Citations
15
Small, Journal Year: 2024, Volume and Issue: 20(44)
Published: July 6, 2024
Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.
Language: Английский
Citations
11
Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2797 - 2797
Published: Oct. 2, 2024
Bone repair and regeneration require physiological cues, including mechanical, electrical, biochemical activity. Many biomaterials have been investigated as bioactive scaffolds with excellent electrical properties. Amongst biomaterials, piezoelectric materials (PMs) are gaining attention in biomedicine, power harvesting, biomedical devices, structural health monitoring. PMs unique properties, such the ability to affect movements deliver stimuli damaged bone or cells without an external source. The crucial property is its piezoelectricity. Bones can generate charges potential response mechanical stimuli, they influence growth regeneration. Piezoelectric respond human microenvironment important factor repair. This manuscript overview of fundamentals generating effect their on paper focuses state art materials, polymers, ceramics, composites, application tissue engineering. We present information from point view highlight promising upcoming approaches new generations materials.
Language: Английский
Citations
8
Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)
Published: Feb. 4, 2024
Abstract Keloids are benign fibroproliferative tumors that severely diminish the quality of life due to discomfort, dysfunction, and disfigurement. Recently, ultrasound technology as a noninvasive adjuvant therapy is developed optimize treatment protocols. However, biophysical mechanisms have not yet been fully elucidated. Here, it proposed piezo‐type mechanosensitive ion channel component 1 (Piezo1) plays an important role in low‐frequency sonophoresis (LFS) induced mechanical transduction pathways trigger downstream cellular signaling processes. It demonstrated patient‐derived primary keloid fibroblasts (PKF), NIH 3T3, HFF‐1 cell migration inhibited, PKF apoptosis significantly increased by LFS stimulation. And effects diminished application GsMTx‐4, selective inhibitor Piezo1, knockdown Piezo1. More importantly, can be imitated Yoda1, agonist Piezo1 channels. Establishing xenograft implantation mouse model further verified these results, decreased volume weight keloids. Moreover, blocking impaired effectiveness treatment. These results suggest inhibits malignant characteristics keloids activating channel, thus providing theoretical basis for improving clinical
Language: Английский
Citations
6
Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 1, 2024
Abstract The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing repair regeneration bone defects. Numerous characteristics should be noticed repair, such as irregular morphology defects, homeostasis between hosts microorganisms cavity complex periodontal structures that facilitate epithelial ingrowth. Therefore, necessitates restoration materials adhere to stringent specific demands. This review starts exploring these particular requirements by introducing bones then summarizes classifications current respect composition structure. Additionally, we discuss modifications including improving mechanical properties, optimizing surface topography pore adding bioactive components elements, compounds, cells their derivatives. Ultimately, organize a range potential optimization strategies future perspectives for enhancing materials, physical environment manipulation, microbial modulation, osteo-immune regulation, smart stimuli-responsive multifaceted approach poly-pathic treatment, hope providing some insights researchers this field. In summary, analyzes demands especially alveolar bone, concludes corresponding biomaterials aims inspire research pursuit more effective treatment outcomes.
Language: Английский
Citations
6
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155040 - 155040
Published: Aug. 23, 2024
Language: Английский
Citations
6